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Volume 71, Issue 2, February 2016
Leading Articles
Journal of Antimicrobial Chemotherapy: in the beginning …
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 283–284, https://doi.org/10.1093/jac/dkv401
Antifungal therapy: drug–drug interactions at your fingertips
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 285–289, https://doi.org/10.1093/jac/dkv350
A comprehensive knowledge base on antifungal drugs is now available online to help maximize the chance of therapeutic success whilst minimizing the risk of treatment-related side effects due to drug–drug interactions.
Review
The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public–private partnerships for the development of new strategies to tackle antibiotic resistance
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 290–295, https://doi.org/10.1093/jac/dkv339
Systematic review
Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by Enterobacter, Citrobacter or Serratia species: a systematic review with meta-analysis
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 296–306, https://doi.org/10.1093/jac/dkv346
ORIGINAL RESEARCH
Characterization of novel conjugative multiresistance plasmids carrying cfr from linezolid-resistant Staphylococcus epidermidis clinical isolates from Italy
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 307–313, https://doi.org/10.1093/jac/dkv341
Specific gyrA gene mutations predict poor treatment outcome in MDR-TB
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 314–323, https://doi.org/10.1093/jac/dkv360
Evidence for the critical role of a secondary site rpoB mutation in the compensatory evolution and successful transmission of an MDR tuberculosis outbreak strain
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 324–332, https://doi.org/10.1093/jac/dkv345
Susceptibility testing breakpoints for Mycobacterium tuberculosis categorize isolates with resistance mutations in gyrA as susceptible to fluoroquinolones: implications for MDR-TB treatment and the definition of XDR-TB
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 333–338, https://doi.org/10.1093/jac/dkv353
Increase in bacteraemia cases in the East Midlands region of the UK due to MDR Escherichia coli ST73: high levels of genomic and plasmid diversity in causative isolates
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 339–343, https://doi.org/10.1093/jac/dkv365
Lateral dissemination and inter-patient transmission of blaKPC-3: role of a conjugative plasmid in spreading carbapenem resistance
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 344–347, https://doi.org/10.1093/jac/dkv356
A single-day point-prevalence study of faecal carriers in long-term care hospitals in Madrid (Spain) depicts a complex clonal and polyclonal dissemination of carbapenemase-producing Enterobacteriaceae
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 348–352, https://doi.org/10.1093/jac/dkv355
A real-time PCR assay for direct characterization of the Neisseria gonorrhoeae GyrA 91 locus associated with ciprofloxacin susceptibility
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 353–356, https://doi.org/10.1093/jac/dkv366
Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 357–361, https://doi.org/10.1093/jac/dkv332
Deep analysis of HIV-1 natural variability across HIV-1 variants at residues associated with integrase inhibitor (INI) resistance in INI-naive individuals
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 362–366, https://doi.org/10.1093/jac/dkv333
Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 367–371, https://doi.org/10.1093/jac/dkv359
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 372–386, https://doi.org/10.1093/jac/dkv335
Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 387–394, https://doi.org/10.1093/jac/dkv363
Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 395–402, https://doi.org/10.1093/jac/dkv375
Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 403–412, https://doi.org/10.1093/jac/dkv340
Searching for new strategies against polymicrobial biofilm infections: guanylated polymethacrylates kill mixed fungal/bacterial biofilms
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 413–421, https://doi.org/10.1093/jac/dkv334
Resistance patterns in clinical isolates of pathogenic Actinomyces species
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 422–427, https://doi.org/10.1093/jac/dkv347
Antibacterial activity of achievable epithelial lining fluid exposures of Amikacin Inhale with or without meropenem
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 428–437, https://doi.org/10.1093/jac/dkv370
Staphylococcus aureus develops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 438–448, https://doi.org/10.1093/jac/dkv371
In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 449–459, https://doi.org/10.1093/jac/dkv367
Efficacy of dalbavancin in the treatment of MRSA rat sternal osteomyelitis with mediastinitis
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 460–463, https://doi.org/10.1093/jac/dkv357
Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 464–470, https://doi.org/10.1093/jac/dkv349
The profound pharmacokinetic variability of linezolid given twice daily at 600 mg iv to patients on renal replacement therapy indicates that the EUCAST breakpoint of 2 mg/L is unlikely to be achieved.
Pharmacokinetics of vancomycin and dosing recommendations for trauma patients
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 471–479, https://doi.org/10.1093/jac/dkv372
Guidelines for vancomycin dosing for patients with trauma will allow trough concentrations of 15-20 mg/L and AUC0-24/MIC ratios >400 to be achieved after 4 days of treatment.
Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 480–483, https://doi.org/10.1093/jac/dkv358
Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 484–489, https://doi.org/10.1093/jac/dkv342
Immunity, inflammation and reservoir in patients at an early stage of HIV infection on intermittent ART (ANRS 141 TIPI Trial)
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 490–496, https://doi.org/10.1093/jac/dkv369
Primary antifungal prophylaxis in adult patients with acute lymphoblastic leukaemia: a multicentre audit
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 497–505, https://doi.org/10.1093/jac/dkv343
Vascular access complications during outpatient parenteral antimicrobial therapy at home: a retrospective cohort study
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 506–512, https://doi.org/10.1093/jac/dkv344
Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 513–520, https://doi.org/10.1093/jac/dkv361
Impact of the MIC of piperacillin/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the Bacteraemia-MIC project
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 521–530, https://doi.org/10.1093/jac/dkv362
Randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy of polyhexanide for topical decolonization of MRSA carriers
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 531–538, https://doi.org/10.1093/jac/dkv331
Antimicrobial de-escalation of treatment for healthcare-associated pneumonia within the Veterans Healthcare Administration
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 539–546, https://doi.org/10.1093/jac/dkv338
Validating hospital antibiotic purchasing data as a metric of inpatient antibiotic use
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 547–553, https://doi.org/10.1093/jac/dkv373
Antimicrobial stewardship: are we failing in cross-specialty clinical engagement?
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 554–559, https://doi.org/10.1093/jac/dkv337
Research Letters
Relevance of tcrYAZB operon acquisition for Enterococcus survival at high copper concentrations under anaerobic conditions
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 560–563, https://doi.org/10.1093/jac/dkv330
Infection by and dissemination of NDM-5-producing Escherichia coli in China
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Pages 563–565, https://doi.org/10.1093/jac/dkv352
Letter to the Editor
Comment on: Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae
Journal of Antimicrobial Chemotherapy, Volume 71, Issue 2, February 2016, Page 566, https://doi.org/10.1093/jac/dkv348
