Volume 104, Issue 3, March 2019

Pasireotide rescue therapy failed to prevent hypoglycemic episodes in a rare case of adult nesidioblastosis and masked insulinoma relapse.

Primitive adrenal insufficiency was diagnosed in patients on lenvatinib or vandetanib and prompt improvement in the degree of fatigue was documented upon cortisone acetate replacement treatment.

The co-prescription of testosterone and SGLT2i in patients with hypogonadism and T2DM, conditions frequently associated, may induce erythrocytosis and should prompt clinicians to a careful monitoring.

We report a patient with pseudohypoparathyroidism type Ia and renal failure due to reasons independent of the primary disease, with normalized biochemical abnormalities after renal transplantation.

We describe the utility of a blood-based multigene PCR neuroendocrine measurement (NETest) to detect hepatic micrometastases in a patient with negative blood biomarkers and anatomical/functional imaging.

We present an autopsy description of congenital generalized lipodystrophy, type 4. Fat cells interdigitating cardiac muscle fibers and fibro-fatty infiltration could explain life-threatening arrhythmias.

A review on corticotroph tumor-directed pharmacological agents and their rationale and perspective for the treatment of Cushing disease.

Single oral doses up to 800 mg of 11β-MNTDC are well tolerated and resulted in increases in serum 11β-MNT (an androgen with progestational activity) and suppression of testosterone in healthy men.

High body-weight variability was associated with higher mortality in this 16-year prospective cohort study.

We show that a selective β₂-adrenergic agonist increases leg glucose uptake and clearance at rest, but decreases clearance during exercise in healthy active young men.

In a five-country cohort of 10,403 patients treated with recombinant growth hormone, meningioma risk was greatly raised in relation to radiotherapy, but not apparently related to growth hormone.

High glucose-enhanced FTO expression resulted in an m6A decrease. FTO induced FOXO1, G6PC, and DGAT2 expression and was associated with glucose metabolism.

Iron could limit AT expansion by its link with lipid storage gene expression. Overfeeding increased AT lipid storage gene expression and modulated iron genes expression.

Knowledge of GDM pathogenesis remains incomplete. We studied if serum ADM levels are elevated in subjects with GDM and assessed its possible inhibitory effects on insulin secretion.

Despite declines in lean mass and absolute muscle strength, relative muscle strength and physical performance significantly improved in adults with morbid obesity after Roux-en-Y gastric bypass surgery.

Maternofetal outcomes of medical and surgical management were compared. Rates of preeclampsia and preterm delivery were higher in medically treated patients. The study was limited by its small size.

An investigation during two decades shows that metabolically health obesity is dynamic, and over time individuals with the condition develop metabolic abnormalities and clinical disease.

The French TENGEN network has interpreted 370 MEN1 variants and registered 1676 MEN1-positive patients in the UMD-MEN1 database. Clinical data were analyzed to determine the patients’ outcomes.

Accepting that most people sleep 7 to 8 hours, ∼8-hourly salivary cortisone measurements provide a noninvasive method of estimating 24-hour cortisol exposure in population studies.

Over time an increase in area-level use of thyroid ultrasound as initial imaging has been associated with an increase in thyroid cancer incidence, including incidence of low-risk thyroid cancer.

This is a report of application of mindfulness strategies in the context of a tier 3 obesity service in the United Kingdom demonstrating its efficacy for positive change in eating-related behaviors.

Irisin was evaluated in prepubertal children with GHD at baseline and during 12 months of GH treatment, showing a significant increase in its levels mainly correlated to the change in BMI and IGF-I levels.

Preconception data, among women with PCOS, were used to predict adverse obstetric and perinatal outcomes. Hyperandrogenism and markers of glucose regulation were key predictors of adverse outcomes.

This study demonstrates an increased cortisol secretion in response to a psychosocial stressor following antenatal synthetic glucocorticoid therapy that persists from childhood into adolescence.

In a hypothesis-driven randomized clinical trial after CUG with GH treatment, a 50% reduction of an individualized GH dose maintained channel parallel growth (i.e., normal height velocity).

We investigated patients with rare diabetes forms HNF4A-MODY (n = 44) and HNF1B-MODY (n = 35) in the DPV registry and characterized phenotype and treatment of these two rare forms of MODY diabetes.

The GH response to OGTT may reflect the underlying biological heterogeneity of somatotropinomas and describe its predictive role on somatostatin analogue response in acromegaly.

Placental glucose consumption significantly influenced maternal–fetal glucose transfer in healthy human pregnancies.

A first-in-human trial was performed with a novel somatostatin-dopamine chimeric compound, BIM23B065. BIM23B065 was able to reduce GH and prolactin levels in healthy volunteers.

Insulin resistance and adiposity are negative predictors of bone mass. In the present study, the inverse relationship between adiposity and bone was mediated through insulin resistance.

We describe changes in body fat distribution (BFD) occurring in ART-naive patients starting different regimens. Current antiretroviral regimens have little impact on BFD during the first years of treatment.

Clomiphene was administered to male recreational athletes for 1 month. Testosterone levels increased during treatment, and drug use was evident via urinary detection for >9 months after use.

We found that the IGF-I lowering of pasireotide LAR correlated with that of first-generation SRLs in acromegaly. Both treatments were correlated to SSTR2 protein expression on somatotroph adenomas.

We studied the effect of lipid on LPS-mediated inflammation and TNFα-mediated IR in PCOS. We found an obesity-related LPS response worsened by PCOS and an obesity-independent mechanism of IR in PCOS.

We measured 76 cytokines in obese and lean patients and in obese patients after bariatric surgery. Thirteen cytokines were higher and four lower in obesity. Soluble vascular endothelial growth factor receptor 2 decreased and chemokine (C-X-C motif) ligand 12 increased with surgery.

Plasma AgRP levels are elevated in CD, are strongly correlated with cortisol concentrations, and decline following curative transsphenoidal surgery.

AKAP13 was bound to PRB and augmented progesterone-dependent gene activation via an ERK-dependent mechanism in uterine fibroid cells.

Commentary placing genetic ancestry markers and racial difference in HbA1c in the context of more common variations in the HbA1c-average glucose relationship and their clinical implications.

Commentary on a report of the application of mindfulness strategies within a “tier 3” multidisciplinary weight loss program to improve eating behaviors and facilitate weight loss.