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Targeted Synthesis and Delivery of Steroids from Thymic Epithelial Cells to Developing T cells Drives Immunological Fitness
Jonathan D Ashwell and others
Adaptive immunity depends on generation of a hugely diverse repertoire of T cell antigen receptors (TCRs). T cells develop in the thymus, where random genetic recombination produces this diverse TCR repertoire, and subsequent testing against self-antigens removes autoreactive T cells that might predispose to autoimmunity. ...
Blockade of Tumor Glucocorticoid Recycling Suppresses Regulatory T Cells to Inhibit Tumor Growth
Jonathan D Ashwell and others
Glucocorticoids (GCs) are steroid hormones with potent immunosuppressive properties. GCs are primary produced from cholesterol in the adrenals via de novo synthesis. In some tissues, however, inactive GC metabolites (dehydrocorticosterone in rodents, cortisone in humans) are recycled into active glucocorticoids by the ...
Adipose Farnesoid X Receptor Deletion Results in Hepatic Fat Accumulation upon Diet Induced Obesity
Ximena Yrigoyen-Rosas and others
The nutrient sensor farnesoid X receptor (FXR) transcriptionally regulates whole-body lipid and glucose homeostasis. Several studies examined FXR modulation as a modality to treat obesity with varying conflicting results, emphasizing the need to study tissue-specific roles of FXR. We show that deletion of adipocyte Fxr is ...
ARID1A Suppresses Proliferative Signaling Driven by Estrogen Receptor alpha in Endometrial Cancer
Jacob T Polaski and others
Endometrial cancer (EC) is the most common gynecologic cancer in the United States and is now the 4 th most common cancer in women. With rising incidence and declining 5-year survival rates over the last several decades, EC is now responsible for over 12,500 deaths per year. Most EC tumors (∼85%) express estrogen receptor ...
A Common Polymorphism Allows Nuclear Receptors to Activate WNT4 Signaling to Drive Aggressive Phenotypes in Ovarian Cancer
Benjamin G Bitler and others
Ovarian cancer is the most lethal gynecologic malignancy amongst women with more than 70% of epithelial ovarian cancer (OvCa) incidences diagnosed at late stage, resulting in decreased five-year survival rates of approximately 48%. Risk factors for OvCa beyond BRCA1/2 are not well understood; one possible risk factor may ...
Transcriptomic Analysis of MDC1 as a Novel Coregulator of Estrogen Receptor in ILC
Carmen Rowland and others
Invasive lobular carcinoma (ILC) is a subtype of breast cancer that accounts for roughly 15% of all cases and is primarily estrogen receptor α (ER) positive. Although strongly dependent on estrogen, ILC exhibits unique resistance to antiestrogen therapy. We profiled the ER interactome and identified an ILC-specific ...
Use of an F-Dex Monocyte Binding Assay to Measure Steroid Responsiveness of Patients with Acute Graft versus Host Disease
Christina Cho and others
Objectives The major cause of morbidity following stem cell transplant is acute graft-versus-host disease (aGVHD). The mainstay of treatment for aGVHD is corticosteroids with 50% of these patients having a steroid refractory form. These steroid refractory aGVHD patients face increased risk of continued advancement of aGVHD ...
WNT4 Mediates AMPK Activation and Metabolic Plasticity in Breast and Gynecologic Cancers
Benjamin G Bitler and others
Introduction In lobular breast cancer cells, estrogen upregulates expression of the Wnt ligand WNT4, which we find regulates cellular metabolism and metabolic plasticity. A similar pathway is active in ovarian cancer, where a germline variant at the estrogen receptor α binding site in WNT4 (rs3820282) mediates increased ...
Engineering an Estradiol Sensor for Real-Time Detection of Hormones in the Brain
Aida Moghadasi and others
Emerging evidence suggests that estradiol (E2), a potent agonist of estrogen receptors, plays a modulatory role in various brain functions, including mood regulation, cognitive processes, and reproductive behaviors 1 . Nevertheless, circuit- and cell-type-specific studies of E2 in vivo remain challenging due to the absence ...
Molecular Mechanism of a Novel DMD Treatment Targeting Glucocorticoid and Mineralocorticoid Receptors: Anti-Inflammatory and Cardioprotective Actions
Xu Liu
Duchenne muscular dystrophy (DMD) is a chronic devastating muscular dystrophy with an incidence rate of 1 in 5000 boys and an average life expectancy below 30 years. The DMD symptoms begin in early childhood and manifest as weakness and degeneration of muscle tissues in the pelvic area and the upper limbs, ultimately leads ...

Endocrinology Areas of Focus:

  • Adrenal
  • Diabetes, Pancreatic and Gastrointestinal Hormones
  • Endocrine Disrupting Chemicals
  • Growth, Growth Hormone, and Growth Factors
  • Hormones and Cancer
  • Lipids and Cardiovascular
  • Nuclear Receptors and their Ligands
  • Obesity and Adipocyte Biology
  • Parathyroid, Bone, and Mineral Metabolism
  • Pituitary and Neuroendocrinology
  • Reproductive Biology and Sex-Based Medicine
  • Signaling Pathways
  • Thyroid
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Endocrinology's former Editor-in-Chief, Carol A Lange, PhD, and Stephen R Hammes, MD, PhD, past Editor-in-Chief of Molecular Endocrinology share critical tips on how to get published.

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