Volume 115, Issue 2, February 2024

The proliferating cell nuclear antigen scaffold differentially binds hexokinase, procaspase-9, and p47^phox to regulate neutrophil metabolism, viability and activation state.

G-CSF changes the PCNA scaffold, affecting interactions with key glycolytic enzymes and thereby regulating glycolysis in neutrophils.

Panton-Valentine leukocidin induces nonlethal extracellular traps in neutrophils, which may serve as an evasion strategy of PVL-producing S. aureus.

The intratumoral function of natural killer cells is sensitive to the tumor microenvironment and controls its phenotype and cytolytic function. We discuss how molecular interactions drive the function of natural killer cells.

The diversity and plasticity of immune cells are involved in myocarditis.

Neutrophil–DV-2 interaction modulates the phenotype and effector functions of neutrophils that may have both beneficial and detrimental effects.

The generation and use of εTRuC γδ T cells is a new proof of concept for cancer immunotherapy.

NKG2D impacts thymic T cell development at a fundamental level by reducing the TCR components and affecting the functional imprint of the thymic progeny.

Our study revealed that SRA plays a critical role in macrophage inflammatory response by targeting Notch1 for its glutathionylation, and SRA-mediated negative regulation of Notch activation might serve as a novel therapeutic strategy for alcohol-induced liver injury.

In this study, we have prospectively analyzed natural killer cell function and phenotype in matched blood and bone marrow samples from precursor B cell acute lymphoblastic leukemia patients at diagnosis and throughout treatment.

In this study, 3-dimensional liver cancer spheroids incorporating human primary monocytes were used to investigate the crosstalk between tumor-associated macrophages. The results identified the cholesterol metabolism pathway as a major pathway that drives the macrophages to adopt protumor phenotypes. Inhibiting a key enzyme in this pathway in cancer spheroid-infiltrating macrophages reduces tumor growth and invasive phenotypes.

Structurally dissimilar ligands of diverse origin that induce distinct changes in transcription and metabolism in macrophages can converge toward common pathways to enhance antimicrobial responses.

Leptin has an effect on systemic inflammation and innate immune cell function in the context of obesity in vitro and in vivo.

MFG-E8–derived oligopeptide 3 promotes the clearance of a new damage-associated molecular pattern, extracellular cold-inducible RNA-binding protein, by macrophages through α_vβ₃-integrin to attenuate acute lung injury and mortality in polymicrobial sepsis.

Human thymus contains different maturation stages of invariant natural killer T cells and facilitates sublineage commitment with invariant natural killer T2 properties in the most immature cells and an invariant natural killer T1 signature in the more differentiated clusters.

Human thymus contains different maturation stages and facilitates sublineage commitment of invariant natural killer T cells.