Volume 115, Issue 1, January 2024

We identify neutrophils as a critical cellular target of interleukin-10–directed immune suppression, as neutrophil-mediated clearance of Streptococcus pneumoniae is improved in the absence of interleukin-10 receptor.

Commentary on the findings presented in the original manuscript by Yang et al., 2023, published in the Journal of Leukocyte Biology.

Six transcriptomically distinct clusters of regulatory T cells with cross-tissue conserved hallmarks of aging are identified in this study.

Single-cell multimodal technologies are crucial for understanding the heterogeneity and specialized functions of γδ T cells, uncovering novel therapeutic opportunities in various diseases, including cancer.

The review summarizes the current understanding of lipid metabolism in regulating tumor-prone hepatic immune microenvironment and perspectives of targeting lipid metabolism for combinatory immunotherapy in liver cancers.

This review highlights the application and future direction of organoids in COVID-19 research.

Extracellular traps formed in rheumatoid arthritis are a significant contributor in rheumatoid arthritis pathogenesis. Macrophage extracellular traps promoted rheumatoid arthritis fibroblast-like synoviocytes through cGAS-mediated activation of the PI3K-Akt-ERK/NF-κB signaling pathways.

Our study thus provides evidence that dengue virus serotype 2 can accelerate the differentiation of bone marrow progenitor cells into neutrophils through MPO and modulate their functions.

Characterization of memory responses of human γδ T cells to Bacillus Calmette–Guérin vaccination.

Knockdown of Bmal1 in macrophages suppresses eosinophilic inflammation in chronic house dust mite–induced allergy, which is correlated to the phagocytosis and prostanoid production in macrophages.

Combined treatment of Astragalus membranaceus (Fisch.) Bge. and Coriolus versicolor can act as adjuvants with messenger RNA vaccine to improve the antibody activities against SARS-CoV-2, probably via macrophages/dendritic cells.

Toll-like receptor 4 activation in plasmacytoid dendritic cells induces an alternative activation state that shares similarities to toll-like receptor 7/8 activation but with its own distinct traits and enhances antiviral functions to SARS-CoV-2 coronavirus.