Volume 115, Issue 3, March 2024

This study offers important mechanistic insights into the role of transforming growth factor β in macrophage metabolism and coagulation, which may reveal key metabolic targets for modulating inflammatory pathologies.

Neutrophil abnormalities are present in patients with cystic fibrosis treated with CFTR modulators.

This work, by using the single-cell RNA sequencing technology, reveals intrinsic differences in gene programming between neutrophils from patients with cystic fibrosis and healthy control participants, which provides a transcriptional explanation to the hyperinflammatory nature of cystic fibrosis neutrophils.

This study explores how inhibiting lysine deacetylases affect macrophages, which play a key role in the immune system. Lysine deacetylase inhibition resulted in reduced production of inflammatory mediators in lipopolysaccharide-treated macrophages, but only minor changes in macrophage metabolism were observed. Lysine deacetylase inhibition specifically enhanced the expression of proteins involved in ubiquitination, which may be a driver of the anti-inflammatory effects of lysine deacetylase inhibitors. A multiomics approach provides novel insights into how macrophages interact with cues from their environment.

CD44 is a new receptor of CD6 and CD6 interacts with all 3 identified receptors to regulate cytoskeleton redmodeling.

Amoxicillin treatment of Streptococcus pneumoniae infection influenced emergency granulopoiesis in the bone marrow and led to the generation of mature neutrophils with distinct antimicrobial functions and migratory capabilities.

For better understanding whether CAR T cells effectively infiltrate into tumor site and simultaneously, whether there are off-target effects, we constructed a novel reporter gene ΔPSMA to track the distribution of CAR T cells in vivo by ⁶⁸Ga-PSMA-617. Results showed that CAR T cells expressing truncated PSMA retained the cytolytic functions against target cells and approximately 1 × 10⁴ engineered CAR T cells could be identified by the pairing of PSMA and ⁶⁸Ga-PSMA-617.

B cell TLR7 expression and ABCs are increased in a pSD model and TLR7-stimulated ABCs derived from pSD females show pathogenic potential.

TIPE family proteins are essential for sensing chemokine gradients and guiding human T cell migration.

We systematically analyzed the stages and cellular components of granulomas in Mycobacterium marinum–infected adult zebrafish, which will provide a reference for future studies.

During hyphal growth, Candida albicans release high levels of short-chain fatty acids which can function as end-point chemoattractants directing neutrophils toward invasive growth forms of C. albicans.

LPS-induced increase in human LAIR1 is regulated by NFKB factors, while IFN-γ–induced increase in mouse LAIR1 is controlled by STAT3 and STAT5.

Cxcl1’s ability to exist as both monomer and dimer and their different receptor affinities coordinate the early events in neutrophil recruitment.

We define conditions promoting or impairing antibody staining of CD115, the receptor for colony stimulating factor 1, frequently used for monocyte and macrophage definition.