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Volume 168, Issue 1, March 2019
LOOK INSIDE TOXSCI
From the Editor's Desk, Editor's Highlights
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 1–2, https://doi.org/10.1093/toxsci/kfz033
3D GI MODELS FOR PREDICTING DRUG-INDUCED DIARRHEA
Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 3–17, https://doi.org/10.1093/toxsci/kfy268
PRO-METASTATIC EFFECTS OF ARSENIC
Arsenic May Act as a Pro-Metastatic Carcinogen Through Promoting Tumor Cell-Induced Platelet Aggregation
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 18–27, https://doi.org/10.1093/toxsci/kfy247
NUCLEAR RECEPTOR FUNCTION IN ZEBRAFISH
Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 28–39, https://doi.org/10.1093/toxsci/kfy269
PXR AND CAR EFFECTS ON INTESTINAL BILE ACID METABOLISM
Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 40–60, https://doi.org/10.1093/toxsci/kfy271
DELTAMETHRIN EFFECTS AND ACOUSTIC STARTLE RESPONSE IN RATS
Effects of Acute Deltamethrin Exposure in Adult and Developing Sprague Dawley Rats on Acoustic Startle Response in Relation to Deltamethrin Brain and Plasma Concentrations
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 61–69, https://doi.org/10.1093/toxsci/kfy275
iPSC-DERIVED CARDIOMYOCYTES AND ARRHYTHMIA TESTING
Arrhythmogenicity Test Based on a Human-Induced Pluripotent Stem Cell (iPSC)-Derived Cardiomyocyte Layer
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 70–77, https://doi.org/10.1093/toxsci/kfy274
MEDICAL DEVICE-DERIVED BISPHENOLS AND PHTHALATES AND RECOVERY FROM MYOCARDIAL INFARCTION
Recovery From a Myocardial Infarction Is Impaired in Male C57bl/6 N Mice Acutely Exposed to the Bisphenols and Phthalates That Escape From Medical Devices Used in Cardiac Surgery
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 78–94, https://doi.org/10.1093/toxsci/kfy276
PCB 95 AND DENDRITIC ARBORIZATION EFFECTS ARE SEX-DEPENDENT
Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 95–109, https://doi.org/10.1093/toxsci/kfy277
MUSCLE miRNAS TO DETECT DRUG-INDUCED INJURY
A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 110–125, https://doi.org/10.1093/toxsci/kfy282
ROCK INHIBITION AND METHYLMERCURY-INDUCED AXONAL DEGENERATION
Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 126–136, https://doi.org/10.1093/toxsci/kfy281
1,2-DICHLOROPROPANE AND UPREGULATION OF ACTIVATION-INDUCED CYTIDINE DEAMINASE
Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 137–148, https://doi.org/10.1093/toxsci/kfy280
ALL-TRANS RETINOIC ACID AND TESTICULAR PHTHALATE TOXICITY IN RATS
All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 149–159, https://doi.org/10.1093/toxsci/kfy283
ION CHANNEL AND ADHERENS JUNCTIONS IN TOLUENE DIISOCYANATE ASTHMA MODEL
Transient Receptor Potential Ion Channels Mediate Adherens Junctions Dysfunction in a Toluene Diisocyanate-Induced Murine Asthma Model
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 160–170, https://doi.org/10.1093/toxsci/kfy285
DOXORUBICIN AND CALCIUM RELEASE IN OVARIAN FOLLICLES
Doxorubicin Induces ER Calcium Release via Src in Rat Ovarian Follicles
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 171–178, https://doi.org/10.1093/toxsci/kfy284
IMMUNE PHENOTYPE AND INFLAMMATION IN DERMATIS MODELS
Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 179–189, https://doi.org/10.1093/toxsci/kfy289
ZINC OXIDE NANOPARTICLES AND ALTERNATIVE SPLICING
Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 190–200, https://doi.org/10.1093/toxsci/kfy288
CdTe QUANTUM DOTS AND KIDNEY TOXICITY
Kidney Toxicity and Response of Selenium Containing Protein-glutathione Peroxidase (Gpx3) to CdTe QDs on Different Levels
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 201–208, https://doi.org/10.1093/toxsci/kfy297
ISONIAZID METALITES AND HEME BIOSYNTHESIS
The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 209–224, https://doi.org/10.1093/toxsci/kfy294
SCREENING OF DEVELOPMENTAL NEUROTOXICITY IN ZEBRAFISH
Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 225–240, https://doi.org/10.1093/toxsci/kfy291
CYANOTOXIN AND HEPATIC DIFFERENTIATION FROM HUMAN ES CELLS
Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 241–251, https://doi.org/10.1093/toxsci/kfy293
GENERALIZED CONCENTRATION ADDITION MODEL FOR GLUCOCORTICOID ACTIVITY
Generalized Concentration Addition Model Predicts Glucocorticoid Activity Bioassay Responses to Environmentally Detected Receptor-Ligand Mixtures
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 252–263, https://doi.org/10.1093/toxsci/kfy290
HERBAL INGREDIENT EMODIN AND INTRAHEPATIC CHOLESTASIS
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice
Toxicological Sciences, Volume 168, Issue 1, March 2019, Pages 264–278, https://doi.org/10.1093/toxsci/kfy295
CORRIGENDA
Corrigendum to “The Serosal Immune System of the Thorax in Toxicology”
Toxicological Sciences, Volume 168, Issue 1, March 2019, Page 279, https://doi.org/10.1093/toxsci/kfy227
Corrigendum to “The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems”
Toxicological Sciences, Volume 168, Issue 1, March 2019, Page 280, https://doi.org/10.1093/toxsci/kfy304
Corrigendum to “Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin”
Toxicological Sciences, Volume 168, Issue 1, March 2019, Page 281, https://doi.org/10.1093/toxsci/kfy305
Corrigendum to “Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs”
Toxicological Sciences, Volume 168, Issue 1, March 2019, Page 282, https://doi.org/10.1093/toxsci/kfy310
