... surrogates often fail to reliably predict clinical benefit. Using immunological surrogates of efficacy, deployed in “immunobridging trials”, could present a viable alternative, safely speeding up cancer vaccine development in a cost-effective manner. Whilst this approach has proven successful in infectious...

... accessible in resource-constrained environments. ^{5 , 6} In response to these limitations, few recent studies have explored immunohistochemical (IHC) markers as potential surrogate indicators of 1p/19q co-deletion in oligodendrogliomas. Notably, markers such as Huntingtin-interacting protein 1...

..., provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract LDL cholesterol (LDL - c) and non-HDL cholesterol (non-HDL-c) are prognostic factors of cardiovascular risk. However, their validity as trial-level surrogates for cardiovascular...

.../licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Surrogate-assisted evolutionary algorithms have emerged as powerful tools...

... ethics gestational carrier intended parents surrogate third-party reproduction European Society of Human Reproduction and Embryology The aim of this paper is to consider the ethical issues raised by surrogacy, i.e. when a pregnancy is carried by a gestational carrier or surrogate. For the purpose...

...://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background The slope of estimated glomerular filtration rate (eGFR) is a promising surrogate endpoint in patients with chronic kidney...

... The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g. fasting plasma glucose measured every 6 months for 3 years...

.... Diagnostic metrics of the surrogate virus neutralization assay against the WT strain using the manufacturer’s cut-off. 95% Confidence interval Decision statistics Estimate (%) Lower (%) Upper (%) Test sensitivity 91.4 84.7 95.8 Test specificity 66.7 9.4 99.2...

... are prohibitively expensive with high-fidelity models that are needed to capture today’s ever-more intense and severe wildfires. This work shows that surrogate models trained on related data enable scaling multifidelity uncertainty quantification to high-fidelity wildfire simulations of unprecedented scale...

... bacteriophages for validation purposes was investigated in a test room, before a UV-C based air cleaner was exemplarily evaluated regarding the inactivation of airborne bacteriophages. Methods and results The bacteriophage Phi6 was selected as virus surrogate and aerosolized in a room of 30 m³ volume...

..., distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Surrogate models are commonly used in engineering design to reduce the computational costs of simulations by approximating design variables...

... difficult or expensive to observe, reducing effective sample sizes for estimating average treatment effects (ATEs) even when identifiable. We study how incorporating data on units for which only surrogate outcomes not of primary interest are observed can increase the precision of ATE estimation. We refrain...

... Blackchin Shiner ( Holm et al., 2022 ). They are also ecologically very similar, often being positively associated during surveys ( Carlson, 1997 ; Haynes et al., 2019 ; Potts et al., 2021a ) and are, therefore, an ideal pair for testing the surrogate-species concept...

.../standard_publication_model ) ABSTRACT The identification of surrogate markers is motivated by their potential to make decisions sooner about a treatment effect. However, few methods have been developed to actually use a surrogate marker to test for a treatment effect in a future study. Most existing methods consider...

...Lin H Chen; Andrea Fritzer; Romana Hochreiter; Katrin Dubischar; Stéphanie Meyer The FDA agreed with the μPRNT₅₀ titre of ≥150 as the definition of seroresponse and as a surrogate endpoint. Due to the unpredictability and transient nature of chikungunya outbreaks, it is challenging...

.../standard-publication-reuse-rights ) Abstract Objective This study aimed to determine cost-effectiveness analysis with the surrogate endpoint of mobile targeted active case detection (MTACD) programmes in the early detection of tuberculosis (TB) cases. Methods A cross-sectional study to determine...

... the evidence for a regime shift in the Norwegian Sea and questions earlier reviews of regime shifts across the world’s oceans. changepoint surrogate time series Norwegian Sea false-positive rates STARS EnvCpt Strucchange Chronological Clustering European Union 10.13039/501100000780 862428...

... are understood and respected across different states. Advance directives Healthcare proxy Living will Long-term care Surrogate Advance directives (AD) are legal documents that allow individuals to articulate their healthcare wishes if they become incapacitated and unable to make decisions. The emergence...

... osteoporosis medication fracture risk reduction surrogate meta-regression randomised controlled trial vertebral fracture non-vertebral fracture clinical fracture hip fracture American Society for Bone Mineral Research # 1U01FD007772-01 We have shown that changes in total hip bone mineral density...

.... It could serve as an early surrogate parasitological endpoint in forthcoming clinical trials for NCEs, drug combinations, and new regimens. Supplementary materials are available at The Journal of Infectious Diseases online ( http://jid.oxfordjournals.org/ ). Supplementary materials consist...