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Democratic backsliding damages favorable US image among the global public
Benjamin E Goldsmith and others
US democracy appears to have weakened during the 21st century. Scholars have raised concerns that this democratic backsliding will reduce favorable views of the United States among foreign citizens in other democracies. In turn, observers predict that the eroded global image of the United States ...
Air pollutions affect restaurant and foodservice industry in China
Xu Tian and others
This study examines the impact of air pollution on food away from home (FAFH) consumption in 52 cities across 20 provinces of China, focusing on expenditures for online food delivery (online FAFH) and dine-in restaurants (offline FAFH). Using unique daily aggregated city-level consumption data ...
Metacognitive sensitivity: The key to calibrating trust and optimal decision-making with AI
Doyeon Lee and others
Knowing when to trust and incorporate the advice from artificially intelligent (AI) systems is of increasing importance in the modern world. Research indicates that when AI provides high confidence ratings, human users often correspondingly increase their trust in such judgments, but these ...
Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use
Katie Zhou and others
Interest in using psychedelic drugs to treat psychiatric disorders is growing rapidly. While modern controlled clinical trials show a favorable safety and efficacy profile, it remains unclear if the risk of side effects would increase with broader use in more heterogeneous populations. To address ...
Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice
Sajeeshkumar Madhurakkat Perikamana and others
Aging has been identified as a leading risk factor for many diseases, including neurodegenerative disorders. While cellular senescence has been linked to age-related neurodegenerative conditions, its involvement in peripheral stress-associated brain disorders is just beginning to be explored. In ...
Antibiotics in the global river system arising from human consumption
Heloisa Ehalt Macedo and others
The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due to their toxicity and influence on antimicrobial resistance. After human consumption and partial metabolism, antibiotic residues are excreted and undergo complex accumulation and decay processes ...
The lives of intersex people: Socioeconomic and health disparities in Mexico
Ercio A Muñoz and others
This paper reports socioeconomic and health outcomes for individuals born with sex variations (i.e., intersex individuals) in Mexico based on large nationally representative survey data collected between 2021 and 2022 (N=44,189). The sample includes 608 intersex respondents, corresponding to a ...
The future of in silico trials and digital twins in medicine
Ehsan Samei
In silico trials and digital twins are emerging as transformative medical technologies as they offer a unique way to design medical innovations, optimize their application, and evaluate their utility. Their utility spans from individual care – appropriating the technology for personalized decision, ...

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Introducing PNAS Nexus

Shaping PNAS Nexus: Editor-in-Chief Yannis C. Yortsos

Listen to PNAS Nexus Editor-in-Chief Yannis C. Yortsos’ views on 

•    the interdisciplinary nature of modern research,

•    the inclusive nature of PNAS Nexus,

•    the importance of peer review,

•    balancing technological advancement against potential consequences.

Read an editorial outlining Yortsos' vision for the journal

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Innovative

Innovative

PNAS Nexus provides researchers with an open access platform that encourages transparency and facilitates the rapid publication of high-quality research.

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Extensive scope

PNAS Nexus provides comprehensive scientific coverage by publishing high-quality original research from the fields of engineering and medicine, as well as studies in the social, political, and economic sciences, and mathematics, and the biological and physical sciences more broadly.

Funding and Ethics

Funding and ethics

As a fully open access journal, PNAS Nexus meets all major funder mandates. The journal is committed to high ethical standards and subscribes to the principles of the Committee on Publications Ethics (COPE). 

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