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Analysis of Length-Biased and Partly Interval-Censored Survival Data with Mismeasured Covariates
Li-Pang Chen and Bangxu Qiu
Biometrics, Volume 79, Issue 4, December 2023, Pages 3929–3940, https://doi.org/10.1111/biom.13898
In this paper, we analyze the length-biased and partly interval-censored data, whose challenges primarily come from biased sampling and interfere induced by interval censoring. Unlike existing methods that focus on low-dimensional data and assume the covariates to be precisely measured, sometimes researchers may encounter ...
SAM: Self-Adapting Mixture Prior to Dynamically Borrow Information from Historical Data in Clinical Trials
Peng Yang and others
Biometrics, Volume 79, Issue 4, December 2023, Pages 2857–2868, https://doi.org/10.1111/biom.13927
Mixture priors provide an intuitive way to incorporate historical data while accounting for potential prior-data conflict by combining an informative prior with a noninformative prior. However, prespecifying the mixing weight for each component remains a crucial challenge. Ideally, the mixing weight should reflect the ...
Imputation-Based Q-Learning for Optimizing Dynamic Treatment Regimes with Right-Censored Survival Outcome
Lingyun Lyu and others
Biometrics, Volume 79, Issue 4, December 2023, Pages 3676–3689, https://doi.org/10.1111/biom.13872
Q-learning has been one of the most commonly used methods for optimizing dynamic treatment regimes (DTRs) in multistage decision-making. Right-censored survival outcome poses a significant challenge to Q-Learning due to its reliance on parametric models for counterfactual estimation which are subject to misspecification ...
Conditional Inference in Cis-Mendelian Randomization Using Weak Genetic Factors
Ashish Patel and others
Biometrics, Volume 79, Issue 4, December 2023, Pages 3458–3471, https://doi.org/10.1111/biom.13888
Mendelian randomization (MR) is a widely used method to estimate the causal effect of an exposure on an outcome by using genetic variants as instrumental variables. MR analyses that use variants from only a single genetic region ( cis -MR) encoding the protein target of a drug are able to provide supporting evidence for ...
Group Variable Selection for the Cox Model with Interval-Censored Failure Time Data
Yuxiang Wu and others
Biometrics, Volume 79, Issue 4, December 2023, Pages 3082–3095, https://doi.org/10.1111/biom.13879
Group variable selection is often required in many areas, and for this many methods have been developed under various situations. Unlike the individual variable selection, the group variable selection can select the variables in groups, and it is more efficient to identify both important and unimportant variables or ...

Latest articles

Design and Analysis of Pragmatic Trials by Song Zhang, Chul Ahn, Hong Zhu, Chapman and Hall/CRC, 2023, ISBN: 9781003126010https://www.routledge.com/Design-and-Analysis-of-Pragmatic-Trials/Zhang-Ahn-Zhu/p/book/9781003126010
Bryan Blette
Pragmatic randomized trials are increasingly used for the study of novel interventions as well as for comparative effectiveness research of existing treatments and therapies. A pragmatic trial uses 1 or more “pragmatic” design elements to more closely reflect real-world settings, such as broad ...
Inference with approximate local false discovery rates
Rajesh Karmakar and others
Biometrics, Volume 81, Issue 2, June 2025, ujaf035, https://doi.org/10.1093/biomtc/ujaf035
Efron’s 2-group model is widely used in large-scale multiple testing. This model assumes that test statistics are drawn independently from a mixture of a null and a non-null distribution. The marginal local false discovery rate (locFDR) is the probability that the hypothesis is null given its test ...
Vine copula mixed models for meta-analysis of diagnostic accuracy studies without a gold standard
Aristidis K Nikoloulopoulos
Biometrics, Volume 81, Issue 2, June 2025, ujaf037, https://doi.org/10.1093/biomtc/ujaf037
Numerous statistical models have been proposed for conducting meta-analysis of diagnostic accuracy studies when a gold standard is available. However, in real-world scenarios, the gold standard test may not be perfect due to several factors such as measurement error, non-availability, invasiveness, ...
Statistical inference on the relative risk following covariate-adaptive randomization
Fengyu Zhao and others
Biometrics, Volume 81, Issue 2, June 2025, ujaf036, https://doi.org/10.1093/biomtc/ujaf036
Covariate-adaptive randomization (CAR) is widely adopted in clinical trials to ensure balanced treatment allocations across key baseline covariates. Although much research has focused on analyzing average treatment effects, the inference of relative risk under CAR experiments has been less ...
Estimating weighted quantile treatment effects with missing outcome data by double sampling
Shuo Sun and others
Biometrics, Volume 81, Issue 2, June 2025, ujaf038, https://doi.org/10.1093/biomtc/ujaf038
Causal weighted quantile treatment effects (WQTEs) complement standard mean-focused causal contrasts when interest lies at the tails of the counterfactual distribution. However, existing methods for estimating and inferring causal WQTEs assume complete data on all relevant factors, which is often ...
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