Volume 2, 2021

A comprehensive overview of the importance of metal uptake and resistance mechanisms during Salmonella infections.

Antimicrobial extracellular vesicles produced by organisms ranging from bacteria to humans contribute to host defense against microbes and offer new strategies for the development of therapeutics.

This review covers diverse aspects of outer membrane vesicles as modulators of the innate immune response, as vaccine candidates and as effector delivery vehicles.

Extracellular vesicles and nanotubes could play a profound role in archaeal physiology, evolution and environmental adaptation by promoting intercellular transfer of viral and cellular nucleic acids and proteins.

The study of fungal extracellular vesicles is a fast evolving field which will impact the development of new tools to fight fungal infections in the future.

Review and synthesis on current thinking and gaps in knowledge on how mammalian microRNAs and extracellular vesicles can directly modulate the gut microbiome.

HDACs play important roles in gene regulation and the immune response, thus they are targeted by pathogens to manipulate the host cell and their inhibition may allow to fight infections.

Enterococcal MVs possess unique proteome and lipidome and activate NF-kB signaling in macrophages.

Gradient centrifugation of native cell lysates coupled to sequencing and mass-spectrometry that reveals complexes of RNA and proteins and guides identification of a globally acting RNA-binding protein in C. difficile.

We show that the iron transporter Tsf1 is a key regulator of Drosophila's interaction with the heritable symbiotic bacteria Spiroplasma poulsonii.

Membrane computing technology is able to reproduce in-silico the demographic complexity of a town where COVID-19 is introduced. The model predicts the effect of non-pharmaceutical interventions on the epidemiogical dynamics, severity and mortality of the disease.