Volume 185, Issue 3
August 2010
Cover image
Cover image
On the cover: CXCL13 blockade scrambles tertiary lymphoid organization in pancreatic islets but does not block B lymphocyte invasion. Immunofluorescent staining showing B220+ B cells (pseudocolored pink) and CD3+ T cells (pseudocolored blue) of a typical inflamed islet from a 12-wk-old female NOD mouse treated with CXCL13-blocking Ab from age 3 wk. Henry, R. A., and P. L. Kendall. 2010. CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice. J. Immunol. 185: 1460–1465.
ISSN 0022-1767
EISSN 1550-6606
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Volume 185, Issue 3, August 2010
In this Issue
In This Issue
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1347–1348, https://doi.org/10.4049/jimmunol.1090064
Letters to the Editor
Comment on “Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1349, https://doi.org/10.4049/jimmunol.1090058
Response to Comment on “Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1349–1350, https://doi.org/10.4049/jimmunol.1090059
Comment on “Induction of TGF-β1, Not Regulatory T Cells, Impairs Antiviral Immunity in the Lung following Bone Marrow Transplant”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1350–1351, https://doi.org/10.4049/jimmunol.1090060
Response to Comment on “Induction of TGF-β1, Not Regulatory T Cells, Impairs Antiviral Immunity in the Lung following Bone Marrow Transplant”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1351, https://doi.org/10.4049/jimmunol.1090061
Comment on “CCR5 Dictates the Equilibrium of Proinflammatory IL-17+ and Regulatory Foxp3+ T Cells in Fungal Infections”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1351, https://doi.org/10.4049/jimmunol.1090062
Response to Comment on “CCR5 Dictates the Equilibrium of Proinflammatory IL-17+ and Regulatory Foxp3+ T Cells in Fungal Infections”
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1352, https://doi.org/10.4049/jimmunol.1090063
Pillars of Immunology
Cross-Priming: Its Beginnings
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1353–1354, https://doi.org/10.4049/jimmunol.1090065
Pillars Article: Minor H Antigens Introduced on H-2 Different Stimulating Cells Cross-React at the Cytotoxic T Cell Level during In Vivo Priming. J. Immunol. 1976. 117: 2233–2238
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1355–1360, https://doi.org/10.1093/jimmunol/185.3.1355
Pillars Article: Cross-Priming for a Secondary Cytotoxic Response to Minor H Antigens with H-2 Congenic Cells Which Do Not Cross-React in the Cytotoxic Assay. J. Exp. Med. 1976. 143: 1283–1288
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1361–1366, https://doi.org/10.1093/jimmunol/185.3.1361
Brief Reviews
Alternative Adaptive Immunity in Jawless Vertebrates
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1367–1374, https://doi.org/10.4049/jimmunol.0903128
Cutting Edge
Cutting Edge: CTLA-4–B7 Interaction Suppresses Th17 Cell Differentiation
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1375–1378, https://doi.org/10.4049/jimmunol.0903369
Cutting Edge: CTNNBL1 Is Dispensable for Ig Class Switch Recombination
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1379–1381, https://doi.org/10.4049/jimmunol.1001643
Cellular Immunology and Immune Regulation
Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1383–1392, https://doi.org/10.4049/jimmunol.0903275
Implications for Gene Therapy-Limiting Expression of IL-2Rγc Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1393–1403, https://doi.org/10.4049/jimmunol.0903528
Peripheral 4-1BB Signaling Negatively Regulates NK Cell Development through IFN-γ
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1404–1411, https://doi.org/10.4049/jimmunol.1000850
Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1412–1418, https://doi.org/10.4049/jimmunol.1000560
IFN-αβ and Self-MHC Divert CD8 T Cells into a Distinct Differentiation Pathway Characterized by Rapid Acquisition of Effector Functions
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1419–1428, https://doi.org/10.4049/jimmunol.1001140
Multifront Assault on Antigen Presentation by Japanese Encephalitis Virus Subverts CD8+ T Cell Responses
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1429–1441, https://doi.org/10.4049/jimmunol.0902536
LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1442–1449, https://doi.org/10.4049/jimmunol.1000376
Extracellular Matrix of Glioblastoma Inhibits Polarization and Transmigration of T Cells: The Role of Tenascin-C in Immune Suppression
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1450–1459, https://doi.org/10.4049/jimmunol.0901352
CXCL13 Blockade Disrupts B Lymphocyte Organization in Tertiary Lymphoid Structures without Altering B Cell Receptor Bias or Preventing Diabetes in Nonobese Diabetic Mice
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1460–1465, https://doi.org/10.4049/jimmunol.0903710
Four-and-a-Half LIM Domain Protein 2 Is a Novel Regulator of Sphingosine 1-Phosphate Receptor 1 in CCL19-Induced Dendritic Cell Migration
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1466–1475, https://doi.org/10.4049/jimmunol.0903449
IL-12p35 Promotes Antibody-Induced Joint Inflammation by Activating NKT Cells and Suppressing TGF-β
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1476–1484, https://doi.org/10.4049/jimmunol.1000425
Dendritic Cell-Mediated In Vivo Bone Resorption
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1485–1491, https://doi.org/10.4049/jimmunol.0903560
Distal Regions of the Human IFNG Locus Direct Cell Type-Specific Expression
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1492–1501, https://doi.org/10.4049/jimmunol.1000124
Virulence of Toxoplasma gondii Is Associated with Distinct Dendritic Cell Responses and Reduced Numbers of Activated CD8+ T Cells
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1502–1512, https://doi.org/10.4049/jimmunol.0903450
CD8+ T Cell Responses following Replication-Defective Adenovirus Serotype 5 Immunization Are Dependent on CD11c+ Dendritic Cells but Show Redundancy in Their Requirement of TLR and Nucleotide-Binding Oligomerization Domain-Like Receptor Signaling
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1513–1521, https://doi.org/10.4049/jimmunol.1000338
The Mannose Receptor Mediates the Uptake of Diverse Native Allergens by Dendritic Cells and Determines Allergen-Induced T Cell Polarization through Modulation of IDO Activity
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1522–1531, https://doi.org/10.4049/jimmunol.1000774
Therapeutic Targeting of Syk in Autoimmune Diabetes
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1532–1543, https://doi.org/10.4049/jimmunol.1000983
Tumor-Activated Monocytes Promote Expansion of IL-17–Producing CD8+ T Cells in Hepatocellular Carcinoma Patients
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1544–1549, https://doi.org/10.4049/jimmunol.0904094
TLR2 Is One of the Endothelial Receptors for β2-Glycoprotein I
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1550–1557, https://doi.org/10.4049/jimmunol.1000526
Abatacept Limits Breach of Self-Tolerance in a Murine Model of Arthritis via Effects on the Generation of T Follicular Helper Cells
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1558–1567, https://doi.org/10.4049/jimmunol.1001311
T Cell Activation Leads to Protein Kinase Cθ-Dependent Inhibition of TGF-β Signaling
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1568–1576, https://doi.org/10.4049/jimmunol.1000137
Molecular and Structural Immunology
Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1577–1583, https://doi.org/10.4049/jimmunol.0903888
Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1584–1592, https://doi.org/10.4049/jimmunol.0902502
Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF-κB Pathway
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1593–1605, https://doi.org/10.4049/jimmunol.0903555
A Novel TNF Receptor-Associated Factor 6 Binding Domain Mediates NF-κB Signaling by the Common Cytokine Receptor β Subunit
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1606–1615, https://doi.org/10.4049/jimmunol.0902026
Immunogenetics
Genetic Control of IL-1β Production and Inflammatory Response by the Mouse Irm1 Locus
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1616–1621, https://doi.org/10.4049/jimmunol.1000358
TCRβ Allelic Exclusion in Dynamical Models of V(D)J Recombination Based on Allele Independence
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1622–1632, https://doi.org/10.4049/jimmunol.0904182
Host Defense
Herpes Simplex Virus Type 2 Enhances HIV-1 Susceptibility by Affecting Langerhans Cell Function
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1633–1641, https://doi.org/10.4049/jimmunol.0904137
Immunity to Pre-1950 H1N1 Influenza Viruses Confers Cross-Protection against the Pandemic Swine-Origin 2009 A (H1N1) Influenza Virus
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1642–1649, https://doi.org/10.4049/jimmunol.1000091
Increased CD4+ T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1650–1659, https://doi.org/10.4049/jimmunol.0902626
Dyslipidemia Induces Opposing Effects on Intrapulmonary and Extrapulmonary Host Defense through Divergent TLR Response Phenotypes
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1660–1669, https://doi.org/10.4049/jimmunol.0903501
A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1670–1680, https://doi.org/10.4049/jimmunol.1001240
NLRC5 Limits the Activation of Inflammatory Pathways
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1681–1691, https://doi.org/10.4049/jimmunol.0903900
Heterogeneity among Viral Antigen-Specific CD4+ T Cells and Their De Novo Recruitment during Persistent Polyomavirus Infection
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1692–1700, https://doi.org/10.4049/jimmunol.0904210
Applying TLR Synergy in Immunotherapy: Implications in Cutaneous Leishmaniasis
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1701–1710, https://doi.org/10.4049/jimmunol.1000238
Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1711–1719, https://doi.org/10.4049/jimmunol.1000105
NF-κB RelA Subunit Is Crucial for Early IFN-β Expression and Resistance to RNA Virus Replication
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1720–1729, https://doi.org/10.4049/jimmunol.1000114
The Role of CD80/CD86 in Generation and Maintenance of Functional Virus-Specific CD8+ T Cells in Mice Infected with Lymphocytic Choriomeningitis Virus
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1730–1743, https://doi.org/10.4049/jimmunol.0903894
Antigen-Containing Liposomes Engrafted with Flagellin-Related Peptides Are Effective Vaccines That Can Induce Potent Antitumor Immunity and Immunotherapeutic Effect
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1744–1754, https://doi.org/10.4049/jimmunol.1000027
Secretory-IgA Antibodies Play an Important Role in the Immunity to Streptococcus pneumoniae
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1755–1762, https://doi.org/10.4049/jimmunol.1000831
Human Complement Factor H Binds to Outer Membrane Protein Rck of Salmonella
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1763–1769, https://doi.org/10.4049/jimmunol.1001244
Partial and Ineffective Activation of Vγ9Vδ2 T Cells by Mycobacterium tuberculosis-Infected Dendritic Cells
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1770–1776, https://doi.org/10.4049/jimmunol.1000966
Inflammation
Junctional Adhesion Molecule-C Is a Soluble Mediator of Angiogenesis
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1777–1785, https://doi.org/10.4049/jimmunol.1000556
Acute Hypoxia Induces HIF-Independent Monocyte Adhesion to Endothelial Cells through Increased Intercellular Adhesion Molecule-1 Expression: The Role of Hypoxic Inhibition of Prolyl Hydroxylase Activity for the Induction of NF-κB
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1786–1793, https://doi.org/10.4049/jimmunol.0903244
A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1794–1803, https://doi.org/10.4049/jimmunol.1000430
T Regulatory Cells Control Antigen-Induced Recruitment of Mast Cell Progenitors to the Lungs of C57BL/6 Mice
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1804–1811, https://doi.org/10.4049/jimmunol.1001146
Role of the CXCR4/CXCL12 Axis in Lymphangioleiomyomatosis and Angiomyolipoma
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1812–1821, https://doi.org/10.4049/jimmunol.0902149
sRAGE Induces Human Monocyte Survival and Differentiation
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1822–1835, https://doi.org/10.4049/jimmunol.0903398
Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1836–1845, https://doi.org/10.4049/jimmunol.1000021
GPR17 Regulates Immune Pulmonary Inflammation Induced by House Dust Mites
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1846–1854, https://doi.org/10.4049/jimmunol.1001131
Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1855–1863, https://doi.org/10.4049/jimmunol.0903853
The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-γ in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1864–1877, https://doi.org/10.4049/jimmunol.1000900
Phosphorylation of Leukocyte PECAM and Its Association with Detergent-Resistant Membranes Regulate Transendothelial Migration
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1878–1886, https://doi.org/10.4049/jimmunol.1001305
TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn−/− Mice
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1887–1893, https://doi.org/10.4049/jimmunol.1001227
Poly(ADP-Ribose) Polymerase-1 Is a Determining Factor in Crm1-Mediated Nuclear Export and Retention of p65 NF-κB upon TLR4 Stimulation
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1894–1902, https://doi.org/10.4049/jimmunol.1000646
KdPT, a Tripeptide Derivative of α-Melanocyte–Stimulating Hormone, Suppresses IL-1β–Mediated Cytokine Expression and Signaling in Human Sebocytes
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1903–1911, https://doi.org/10.4049/jimmunol.0902298
Absence of P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host Disease
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1912–1919, https://doi.org/10.4049/jimmunol.0903148
Clinical Immunology
Altered Effector CD4+ T Cell Function in IL-21R−/− CD4+ T Cell-Mediated Graft-Versus-Host Disease
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1920–1926, https://doi.org/10.4049/jimmunol.0902217
Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1927–1934, https://doi.org/10.4049/jimmunol.0904002
Antibodies to HLA-E in Nonalloimmunized Males: Pattern of HLA-Ia Reactivity of Anti–HLA-E–Positive Sera
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1935–1948, https://doi.org/10.4049/jimmunol.1000424
Polymorphic Variants of LIGHT (TNF Superfamily-14) Alter Receptor Avidity and Bioavailability
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1949–1958, https://doi.org/10.4049/jimmunol.1001159
IL-17 Immunity in Human Type 1 Diabetes
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1959–1967, https://doi.org/10.4049/jimmunol.1000788
Inhibition of Glyceraldehyde-3-Phosphate Dehydrogenase Activity by Antibodies Present in the Cerebrospinal Fluid of Patients with Multiple Sclerosis
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1968–1975, https://doi.org/10.4049/jimmunol.0904083
Ischemia Reperfusion Induces IFN Regulatory Factor 4 in Renal Dendritic Cells, which Suppresses Postischemic Inflammation and Prevents Acute Renal Failure
The Journal of Immunology, Volume 185, Issue 3, August 2010, Pages 1976–1983, https://doi.org/10.4049/jimmunol.0904207
Letters of Retraction
Retraction: Activation of Discoidin Domain Receptor 1 Facilitates the Maturation of Human Monocyte-Derived Dendritic Cells Through the TNF Receptor Associated Factor 6/TGF-β-Activated Protein Kinase 1 Binding Protein 1β/p38α Mitogen-Activated Protein Kinase Signaling Cascade
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1984, https://doi.org/10.4049/jimmunol.1090057
Corrections
Correction: Lysophosphatidylcholine Increases Neutrophil Bactericidal Activity by Enhancement of Azurophil Granule-Phagosome Fusion via Glycine·GlyRα2/TRPM2/p38 MAPK Signaling
The Journal of Immunology, Volume 185, Issue 3, August 2010, Page 1985, https://doi.org/10.4049/jimmunol.1090056
