Volume 185, Issue 4
August 2010
Cover image
Cover image
On the cover: Pan–CC chemokine blockade using the viral CC-chemokine inhibitor protein (vCCI) reduces joint destruction and inflammation in a model of arthritis. Representative safranin O/fast green stained section (original magnification × 10) depicting joint of hind paws for vCCI treated animals. Cartilage protection is shown by the preservation of safranin O (red) staining. Buatois, V., S. Fagète, G. Magistrelli, L. Chatel, N. Fischer, M. H. Kosco-Vilbois, and W. G. Ferlin. 2010. Pan–CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis. J. Immunol. 185: 2544–2554.
ISSN 0022-1767
EISSN 1550-6606
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Volume 185, Issue 4, August 2010
In this Issue
In This Issue
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 1989–1990, https://doi.org/10.4049/jimmunol.1090074
Letters to the Editor
Comment on “Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung”
The Journal of Immunology, Volume 185, Issue 4, August 2010, Page 1991, https://doi.org/10.4049/jimmunol.1090071
Response to Comment on “Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung”
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 1991–1992, https://doi.org/10.4049/jimmunol.1090072
Brief Reviews
Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 1993–1998, https://doi.org/10.4049/jimmunol.1000108
Cutting Edge
Cutting Edge: Merocytic Dendritic Cells Break T Cell Tolerance to β Cell Antigens in Nonobese Diabetic Mouse Diabetes
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 1999–2003, https://doi.org/10.4049/jimmunol.1001398
Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2004–2008, https://doi.org/10.4049/jimmunol.1001176
Cutting Edge: KIR Antisense Transcripts Are Processed into a 28-Base PIWI-Like RNA in Human NK Cells
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2009–2012, https://doi.org/10.4049/jimmunol.1000855
Cellular Immunology and Immune Regulation
β-Catenin Signaling Mediates CD4 Expression on Mature CD8+ T Cells
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2013–2019, https://doi.org/10.4049/jimmunol.0902572
c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2020–2031, https://doi.org/10.4049/jimmunol.0902566
Thymocyte-Specific Truncation of the Deubiquitinating Domain of CYLD Impairs Positive Selection in a NF-κB Essential Modulator-Dependent Manner
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2032–2043, https://doi.org/10.4049/jimmunol.0903919
Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2044–2050, https://doi.org/10.4049/jimmunol.1000017
Cbl-b−/− T Cells Demonstrate In Vivo Resistance to Regulatory T Cells but a Context-Dependent Resistance to TGF-β
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2051–2058, https://doi.org/10.4049/jimmunol.1001171
CD45 Regulates Migration, Proliferation, and Progression of Double Negative 1 Thymocytes
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2059–2070, https://doi.org/10.4049/jimmunol.0902693
CD30 Discriminates Heat Shock Protein 60-Induced FOXP3+CD4+ T Cells with a Regulatory Phenotype
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2071–2079, https://doi.org/10.4049/jimmunol.0901901
TLR3 and Rig-Like Receptor on Myeloid Dendritic Cells and Rig-Like Receptor on Human NK Cells Are Both Mandatory for Production of IFN-γ in Response to Double-Stranded RNA
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2080–2088, https://doi.org/10.4049/jimmunol.1000532
Tc17 Cells Are Capable of Mediating Immunity to Vaccinia Virus by Acquisition of a Cytotoxic Phenotype
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2089–2098, https://doi.org/10.4049/jimmunol.1000818
Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2099–2105, https://doi.org/10.4049/jimmunol.0901985
Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2106–2115, https://doi.org/10.4049/jimmunol.1000172
STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2116–2124, https://doi.org/10.4049/jimmunol.1000842
Resident and Monocyte-Derived Dendritic Cells Become Dominant IL-12 Producers under Different Conditions and Signaling Pathways
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2125–2133, https://doi.org/10.4049/jimmunol.0903793
Carbon Monoxide Suppresses Membrane Expression of TLR4 via Myeloid Differentiation Factor-2 in βTC3 Cells
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2134–2139, https://doi.org/10.4049/jimmunol.0902782
Dendritic Cells Continue To Capture and Present Antigens after Maturation In Vivo
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2140–2146, https://doi.org/10.4049/jimmunol.1000642
Altered B Cell Development and Anergy in the Absence of Foxp3
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2147–2156, https://doi.org/10.4049/jimmunol.1000136
Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF-β
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2157–2163, https://doi.org/10.4049/jimmunol.1000359
Secreted pH-Regulated Antigen 1 of Candida albicans Blocks Activation and Conversion of Complement C3
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2164–2173, https://doi.org/10.4049/jimmunol.1001011
Primed Antigen-Specific CD4+ T Cells Are Required for NK Cell Activation In Vivo upon Leishmania major Infection
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2174–2181, https://doi.org/10.4049/jimmunol.1001486
Qualitatively Different Memory CD8+ T Cells Are Generated after Lymphocytic Choriomeningitis Virus and Influenza Virus Infections
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2182–2190, https://doi.org/10.4049/jimmunol.1001142
Clonal Repertoires of Virus-Specific CD8+ T Lymphocytes Are Shared in Mucosal and Systemic Compartments during Chronic Simian Immunodeficiency Virus Infection in Rhesus Monkeys
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2191–2199, https://doi.org/10.4049/jimmunol.1001340
In Hepatic Fibrosis, Liver Sinusoidal Endothelial Cells Acquire Enhanced Immunogenicity
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2200–2208, https://doi.org/10.4049/jimmunol.1000332
MHC Class I Presentation and Regulation by IFN in Bony Fish Determined by Molecular Analysis of the Class I Locus in Grass Carp
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2209–2221, https://doi.org/10.4049/jimmunol.1000347
CD30 Ligand/CD30 Plays a Critical Role in Th17 Differentiation in Mice
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2222–2230, https://doi.org/10.4049/jimmunol.1000024
Respiratory Virus-Induced TLR7 Activation Controls IL-17–Associated Increased Mucus via IL-23 Regulation
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2231–2239, https://doi.org/10.4049/jimmunol.1000733
Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2240–2252, https://doi.org/10.4049/jimmunol.1001307
IgE Transcripts in the Circulation of Allergic Children Reflect a Classical Antigen-Driven B Cell Response and Not a Superantigen-Like Activation
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2253–2260, https://doi.org/10.4049/jimmunol.0902942
IL-3 Inhibits Human Osteoclastogenesis and Bone Resorption through Downregulation of c-Fms and Diverts the Cells to Dendritic Cell Lineage
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2261–2272, https://doi.org/10.4049/jimmunol.1000015
Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2273–2284, https://doi.org/10.4049/jimmunol.1000901
Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2285–2294, https://doi.org/10.4049/jimmunol.1000462
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2295–2305, https://doi.org/10.4049/jimmunol.1000848
Molecular and Structural Immunology
Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Delivers Heat Shock Protein 60-Fused Antigen into the MHC Class I Presentation Pathway
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2306–2313, https://doi.org/10.4049/jimmunol.0903214
A 5′ Extended IFN-Stimulating Response Element Is Crucial for IFN-γ–Induced Tripartite Motif 22 Expression via Interaction with IFN Regulatory Factor-1
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2314–2323, https://doi.org/10.4049/jimmunol.1001053
XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-β Induction via a cis-Acting Enhancer in Macrophages
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2324–2330, https://doi.org/10.4049/jimmunol.0903052
Immunogenetics
An Allelic Variant of Crry in the Murine Sle1c Lupus Susceptibility Interval Is Not Impaired in Its Ability To Regulate Complement Activation
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2331–2339, https://doi.org/10.4049/jimmunol.1000783
An Atopic Dermatitis-Like Skin Disease with Hyper-IgE-emia Develops in Mice Carrying a Spontaneous Recessive Point Mutation in the Traf3ip2 (Act1/CIKS) Gene
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2340–2349, https://doi.org/10.4049/jimmunol.0900694
Regulation of the IL-21 Gene by the NF-κB Transcription Factor c-Rel
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2350–2359, https://doi.org/10.4049/jimmunol.1000317
Host Defense
Stromal Cell-Derived CXCL12 and CCL8 Cooperate To Support Increased Development of Regulatory Dendritic Cells Following Leishmania Infection
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2360–2371, https://doi.org/10.4049/jimmunol.0903673
Inducible Cyclooxygenase Released Prostaglandin E2 Modulates the Severity of Infection Caused by Streptococcus pyogenes
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2372–2381, https://doi.org/10.4049/jimmunol.1000838
Foxp3+ CD4 Regulatory T Cells Limit Pulmonary Immunopathology by Modulating the CD8 T Cell Response during Respiratory Syncytial Virus Infection
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2382–2392, https://doi.org/10.4049/jimmunol.1000423
Suppressor of Cytokine Signaling 3 Inhibits Antiviral IFN-β Signaling To Enhance HIV-1 Replication in Macrophages
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2393–2404, https://doi.org/10.4049/jimmunol.0903563
Mycobacterium tuberculosis and TLR2 Agonists Inhibit Induction of Type I IFN and Class I MHC Antigen Cross Processing by TLR9
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2405–2415, https://doi.org/10.4049/jimmunol.0904005
The Early Generation of a Heterogeneous CD4+ T Cell Response to Leishmania major
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2416–2423, https://doi.org/10.4049/jimmunol.1000483
Inhibitory Role for d-Alanylation of Wall Teichoic Acid in Activation of Insect Toll Pathway by Peptidoglycan of Staphylococcus aureus
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2424–2431, https://doi.org/10.4049/jimmunol.1000625
Severe Listeria monocytogenes Infection Induces Development of Monocytes with Distinct Phenotypic and Functional Features
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2432–2441, https://doi.org/10.4049/jimmunol.1000486
B7-H1 (Programmed Cell Death Ligand 1) Is Required for the Development of Multifunctional Th1 Cells and Immunity to Primary, but Not Secondary, Salmonella Infection
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2442–2449, https://doi.org/10.4049/jimmunol.1000743
Candida albicans Dampens Host Defense by Downregulating IL-17 Production
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2450–2457, https://doi.org/10.4049/jimmunol.1000756
Inflammation
Inflammation in the Central Nervous System and Th17 Responses Are Inhibited by IFN-γ–Induced IL-18 Binding Protein
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2458–2466, https://doi.org/10.4049/jimmunol.0902153
The IFN-γ–Dependent Suppressor of Cytokine Signaling 1 Promoter Activity Is Positively Regulated by IFN Regulatory Factor-1 and Sp1 but Repressed by Growth Factor Independence-1b and Krüppel-Like Factor-4, and It Is Dysregulated in Psoriatic Keratinocytes
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2467–2481, https://doi.org/10.4049/jimmunol.1001426
Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2482–2492, https://doi.org/10.4049/jimmunol.0904019
CD4+CD25+ Regulatory T Cells Prevent Type 1 Diabetes Preceded by Dendritic Cell-Dominant Invasive Insulitis by Affecting Chemotaxis and Local Invasiveness of Dendritic Cells
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2493–2501, https://doi.org/10.4049/jimmunol.1001036
Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2502–2515, https://doi.org/10.4049/jimmunol.0901778
Distinct Roles of Hepatocyte- and Myeloid Cell-Derived IL-1 Receptor Antagonist during Endotoxemia and Sterile Inflammation in Mice
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2516–2524, https://doi.org/10.4049/jimmunol.1000872
Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2525–2535, https://doi.org/10.4049/jimmunol.1000286
A Critical Role for IFN Regulatory Factor 1 in NKT Cell-Mediated Liver Injury Induced by α-Galactosylceramide
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2536–2543, https://doi.org/10.4049/jimmunol.1000092
Pan–CC Chemokine Neutralization Restricts Splenocyte Egress and Reduces Inflammation in a Model of Arthritis
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2544–2554, https://doi.org/10.4049/jimmunol.1000182
The BH3-Mimetic ABT-737 Induces Mast Cell Apoptosis In Vitro and In Vivo: Potential for Therapeutics
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2555–2562, https://doi.org/10.4049/jimmunol.0903656
TLR4 Activation Is Required for IL-17–Induced Multiple Tissue Inflammation and Wasting in Mice
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2563–2569, https://doi.org/10.4049/jimmunol.0903664
Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF-α–Induced Arthritis
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2570–2579, https://doi.org/10.4049/jimmunol.1000644
Clinical Immunology
Efficient Eradication of Subcutaneous but Not of Autochthonous Gastric Tumors by Adoptive T Cell Transfer in an SV40 T Antigen Mouse Model
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2580–2588, https://doi.org/10.4049/jimmunol.0903231
A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2589–2599, https://doi.org/10.4049/jimmunol.1000666
Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2600–2610, https://doi.org/10.4049/jimmunol.1000629
P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2611–2619, https://doi.org/10.4049/jimmunol.1000436
Delaying Bacillus Calmette-Guérin Vaccination from Birth to 4 1/2 Months of Age Reduces Postvaccination Th1 and IL-17 Responses but Leads to Comparable Mycobacterial Responses at 9 Months of Age
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2620–2628, https://doi.org/10.4049/jimmunol.1000552
Corrections
Correction: Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice
The Journal of Immunology, Volume 185, Issue 4, August 2010, Page 2629, https://doi.org/10.4049/jimmunol.1090068
Correction: Expression of Soluble Vascular Endothelial Growth Factor Receptor-1 in Human Monocyte-Derived Mature Dendritic Cells Contributes to Their Antiangiogenic Property
The Journal of Immunology, Volume 185, Issue 4, August 2010, Page 2630, https://doi.org/10.4049/jimmunol.1090069
Correction: Constitutive CD40L Expression on B Cells Prematurely Terminates Germinal Center Response and Leads to Augmented Plasma Cell Production in T Cell Areas
The Journal of Immunology, Volume 185, Issue 4, August 2010, Page 2631, https://doi.org/10.4049/jimmunol.1090070
Correction: HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control
The Journal of Immunology, Volume 185, Issue 4, August 2010, Pages 2632–2633, https://doi.org/10.4049/jimmunol.1090073
