
Contents
43.17 Primary prevention of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy
Get access-
Published:July 2018
Cite
Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by progressive fibrofatty replacement of the myocardium, providing the substrate for ventricular reentrant tachycardia, typical for the overt phase of ARVC. Importantly, life-threatening ventricular arrhythmias may also occur in the concealed phase of the disease. The reported rates for sustained ventricular arrhythmias and all-cause mortality in ARVC differ substantially across cohorts. Survival free from sustained ventricular arrhythmias in patients with ARVC-related pathogenic mutations is approximately 66% and 42% at age 40 and 60 years, respectively, in tertiary referral centres. Participation in competitive sports has been associated with an increased propensity of ventricular arrhythmias/death and should therefore be avoided. Beta-blocker therapy may prevent exercise-induced ventricular arrhythmias and should be considered in all patients with ARVC. In patients with unexplained syncope and other recognized risk factors, the implantation of an implantable cardioverter defibrillator (ICD) for primary prevention may be considered. Decisions should be made carefully, weighing the risk of sudden cardiac death, the lifelong risk of complications, and the impact of an ICD on lifestyle and psychological health. ICDs are associated with significant adverse event rates, in particular in young patients who may carry an ICD for several decades.
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Purchase
Our books are available by subscription or purchase to libraries and institutions.
Purchasing informationMonth: | Total Views: |
---|---|
October 2022 | 12 |
November 2022 | 6 |
December 2022 | 8 |
January 2023 | 6 |
February 2023 | 8 |
March 2023 | 9 |
April 2023 | 19 |
May 2023 | 9 |
June 2023 | 6 |
July 2023 | 2 |
August 2023 | 7 |
September 2023 | 3 |
October 2023 | 6 |
November 2023 | 5 |
December 2023 | 10 |
January 2024 | 22 |
February 2024 | 1 |
March 2024 | 2 |
April 2024 | 5 |
May 2024 | 2 |
June 2024 | 4 |
July 2024 | 3 |
August 2024 | 2 |
December 2024 | 3 |
January 2025 | 2 |
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.