Latest articles

Research Article
Context-dependent interactions between variable-loop pulsed field ablation and cardiac implantable electronic devices: a controlled preclinical study
Masateru Takigawa and others
European Heart Journal Open, Volume 6, Issue 5, September 2026, oeag124, https://doi.org/10.1093/ehjopen/oeag124
Aims Pulsed field ablation (PFA) is increasingly used for atrial fibrillation and is being extended beyond pulmonary vein isolation to right atrial (RA) and superior vena cava (SVC) targets. As its use expands, interactions with cardiac implantable electronic devices (CIEDs) have become an ...
Research Article
Right Ventricular Dysfunction in Cardiogenic Shock on Temporary Mechanical Circulatory Support
Jan Estoppey and others
European Heart Journal Open, oeag139, https://doi.org/10.1093/ehjopen/oeag139
Aims Right ventricular dysfunction (RVD) is common in cardiogenic shock (CS) due to left ventricular failure and associated with increased mortality, but its impact in patients requiring temporary mechanical circulatory support (tMCS) remains unclear. We explored RVD and its association with ...
Research Article
Intravascular Imaging–Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Reconstructed Individual Participant Data Meta-Analysis of Randomized Controlled Trials of IVUS- and OCT-Guided Strategies
Aref A Bin Abdulhak and others
European Heart Journal Open, oeag136, https://doi.org/10.1093/ehjopen/oeag136
Background and Aims Uncertainty persists regarding the comparative efficacy of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) versus angiography-guided percutaneous coronary intervention (PCI). We synthesized randomized evidence using reconstructed individual participant ...
Research Article
Phenotypic Clustering of Atrial Fibrillation Patients Using Latent Class Analysis and Its Potential Utility for Ablation Strategy: Insights from the DIRECT-Extend and EARNEST-PVI Studies
Shun Sasaki and others
European Heart Journal Open, oeag135, https://doi.org/10.1093/ehjopen/oeag135
Aims Atrial fibrillation (AF) is a heterogeneous syndrome. We aimed to assess whether latent class analysis (LCA) can identify phenotypes that stratify prognosis and predict differential responses to catheter ablation strategies. Methods We first developed an LCA-based phenotyping model using the ...
Research Article
Mitral annulus calcification and the risk of infective endocarditis: Insights from DANCAVAS screening Trials
Lytfi Krasniqi and others
European Heart Journal Open, oeag140, https://doi.org/10.1093/ehjopen/oeag140
Aims Risk stratification in infective endocarditis (IE) does not incorporate structural substrates involved in early disease initiation. The aim of this study was to examine the association between mitral annulus calcification (MAC) burden and the risk of IE. Methods This substudy utilized the ...
Research Article
T1 mapping predicts outcome in patients with a systemic right ventricle: A sub-analysis of the SERVE study
Odile Burdet and others
European Heart Journal Open, oeag138, https://doi.org/10.1093/ehjopen/oeag138
Aims In patients with a systemic right ventricle (sRV), the sRV is faced with an increased afterload compared to a right ventricle in sub-pulmonary position leading to the development of fibrosis followed by ventricular dysfunction. Cardiac magnetic resonance (CMR) T1 mapping (T1), and its derived ...

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Review Article
Left bundle branch area pacing: anatomical and physiological features made easy
European Heart Journal Open, Volume 6, Issue 3, May 2026, oeag081, https://doi.org/10.1093/ehjopen/oeag081
Left bundle branch area pacing is being increasingly adopted in routine clinical practice as a more physiological alternative to right ventricular and biventricular pacing. Understanding the concepts of this pacing modality may be a hurdle for the non-electrophysiologist and specialists alike. This review article aims to ...
Review Article
Hormone replacement therapy and cardiovascular risk in postmenopausal women
European Heart Journal Open, Volume 6, Issue 2, March 2026, oeag054, https://doi.org/10.1093/ehjopen/oeag054
Menopause hormone replacement therapy (HRT) remains the main strategy for managing menopausal symptoms and preventing osteoporosis in postmenopausal women. However, its cardiovascular effects are complex and influenced by multiple factors. Early initiation of HRT within 10 years of menopause onset consistently demonstrates ...
Research Article
Tirzepatide compared with semaglutide and 10-year cardiovascular disease risk reduction in obesity: post-hoc analysis of the SURMOUNT-5 trial
European Heart Journal Open, Volume 5, Issue 5, September 2025, oeaf117, https://doi.org/10.1093/ehjopen/oeaf117
Aims Approximately two-thirds of obesity-related mortality is attributable to cardiovascular disease (CVD). The aim of this analysis is to examine predicted CVD risk reduction following weight loss in persons with obesity for primary prevention between tirzepatide and semaglutide, and projected CVD events that could be ...
Research Article
Impact of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular and non-cardiovascular outcomes in patients at high/very-high cardiovascular risk without heart failure: a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials
European Heart Journal Open, Volume 6, Issue 4, July 2026, oeag119, https://doi.org/10.1093/ehjopen/oeag119
Aims To assess the impact of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) on all-cause and cardiovascular (CV) mortality, as well as CV, cerebrovascular, and renal outcomes in patients at high/very-high CV risk without heart failure by a systematic review and meta-analysis of ...
Research Article
Relative efficacy of tafamidis, acoramidis, patisiran and vutrisiran in patients with transthyretin cardiac amyloidosis: a network meta-analysis
European Heart Journal Open, Volume 5, Issue 6, November 2025, oeaf147, https://doi.org/10.1093/ehjopen/oeaf147
Aims Transthyretin cardiac amyloidosis (ATTR-CA) is an important cause of heart failure (HF). Several therapies demonstrated an efficacy in reducing hard and surrogate endpoints. We compared the relative efficacy of therapies evaluated in completed phase III trials. Methods and results We conducted a network meta-analysis ...
Review Article
Variable selection for causal inference, prediction, and descriptive research: a narrative review of recommendations
European Heart Journal Open, Volume 5, Issue 3, May 2025, oeaf070, https://doi.org/10.1093/ehjopen/oeaf070
There is a growing appreciation that the methods and analyses of medical studies should be tailored towards the type of research question. However, frequent conflation exists with respect to the reasons for statistically adjusting for variables in analyses and the methods that should be used for variable selection in ...
  • 4.3
    2025 Impact Factor
  • 60/237
    Cardiac & Cardiovascular Systems (Rank by Impact Factor)
  • 5.6
    2025 CiteScore
  • 102/409
    Cardiology And Cardiovascular Medicine (Rank by CiteScore)

Mental Health and Cardiovascular Disease

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