Intervention, Improved prevention, Imaging, Inflammation, and Innovation are highlights of some major insights from European Heart Journal Open 2024. Those I's also put spotlight on five of the future perspectives in cardiology trajectories towards optimization of diagnosis, interventions, and treatments, as well as novel innovative targets and methods.
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Background Direct oral anticoagulants (DOACs) at reduced dosage regimens are the first choice of ischaemic stroke (IS) prevention for patients with atrial fibrillation (AF) and elevated bleeding risk or renal insufficiency. We compared the outcomes of reduced dose DOACs and warfarin. Methods and ...
Background and aims Various measures have been implemented in clinical practice to reduce the risk of cardiovascular complications during breast cancer (BC) treatment. The aim of this study was to investigate whether women diagnosed with BC exhibit a higher incidence of cardiovascular disease ...
Background Individually optimising the training programme of cardiac rehabilitation (CR) remains a major concern among coronary artery disease (CAD) patients. The power-force-velocity profile (PFVP) for a given task is usually assessed to improve performance in athletes through individualised ...
Background Comparisons of international practice patterns and their impact on percutaneous coronary intervention (PCI) outcomes are lacking. We compared temporal PCI trends between Sweden and a large university hospital system in the U.S. Methods Data within the Swedish Coronary Angiography and ...
Background and Aims Prevalence of cardiovascular diseases (CVD) and depression is rising globally. Their co-occurrence associates with poorer outcomes, potentially due to shared metabolic pathways. This study aimed to identify metabolic pathways linking depression symptoms and CVD risk factors. ...
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Over several decades, the approach to treating dyslipidaemias during pregnancy remains essentially unchanged. The lack of advancement in this field is mostly related to the fact that we lack clinical trials of pregnant patients both with available as well as new therapies. While there are numerous novel therapies developed ...
Cardiac amyloidosis is caused by the extracellular deposition of amyloid fibrils in the heart, involving not only the myocardium but also any cardiovascular structure. Indeed, this progressive infiltrative disease also involves the cardiac valves and, specifically, shows a high prevalence with aortic stenosis. Misfolded ...
The role of physical activity (i.e. any bodily movement that requires energy expenditure) and exercise (i.e. planned, structured, and repetitive physical activity to improve/maintain fitness) in the primary and secondary prevention of atrial fibrillation (AF) is increasingly recognized. Physical activity has been ...
Aims Causes of death remain largely unexplored in the atrial fibrillation (AF) population. We aimed to (i) thoroughly assess causes of death in patients with AF, especially those associated with sudden cardiac death (SCD) and (ii) evaluate the potential association between AF and SCD. Methods and results Linked primary and ...
Aims Natriuretic peptides (NPs) exert pleiotropic effects through the recruitment of cyclic guanosine monophosphate (cGMP) signalling pathways depending on their bioavailability, which is regulated by clearance receptors and peptidases. Here, we tested the hypothesis that increasing myocardial bioavailability of NP has a ...
Aims Apolipoprotein C-III (APOC3) inhibitors are approved for hypertriglyceridaemia. Genetic evidence suggests that APOC3 inhibition may also prevent coronary artery disease (CAD), but mechanisms remain unclear. Methods and results To clarify how APOC3 inhibition could prevent CAD, we performed two-step cis-Mendelian ...
New Collection: Heart and Stroke
Explore an EHJ Open collection focusing on heart disease with a stroke component. This multi-disciplinary collection is in collaboration with the ESC Council on Stroke.
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New Collection: Advances in Cardio-Oncology
To create awareness of cardio-oncology, this EHJ Open article collection assembles the latest progress in management and prevention of cardiovascular disease in oncologic patients.
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