Dr Costantino Iadecola, as a physician-scientist, first spoke about why he focused on neurobiology as a specialization. During his medical course (Sapienza University of Rome), he was obsessed in studying human physiology, discovering the brain as one of the most complex and fascinating aspects of ...
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Neointimal hyperplasia (NIH) characterized by vascular smooth muscle cell (VSMC) dysfunctions plays a critical role in many vascular diseases including atherosclerosis and restenosis, which leads to serious ischemic complications and has limited therapeutic approaches. Our previous studies confirm ...
Thoracic aortic dissection (TAD) is a highly fatal disease lacking effective pharmacologic interventions in clinical practice. Emerging evidence indicates that the natriuretic peptide receptor C (NPR-C) plays a crucial role in the regulation of cardiovascular diseases. However, the precise ...
From time to time, I am asked why I became a cardiologist and cardiovascular researcher. At some level, the answer is easy—a simple conviction that the heart is ‘the most important bit’. The Beating Heart (Head of Zeus/Bloomsbury, 2024; Figure 1A ) is my long overdue exploration of why I, and ...
Cardiovascular disease remains a persistent global health burden, underscoring the necessity for effective therapeutic strategies. Despite significant advances, the ability to mechanistically study human disease and predict clinical outcomes remains limited, especially in complex diseases such as ...
Editor's Choice
Aims Doxorubicin (DOX) is one of the most effective chemotherapeutic agents for various types of cancers. However, DOX often causes cardiotoxicity, which is referred to as DOX-induced cardiomyopathy (DIC). Despite extensive research, only a limited number of effective treatments are currently available. In this study, we ...
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression. In this review, we provide a comprehensive summary and expert commentary on the role of ...
Aims A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart diseases, TZP is involved in cardiac metabolic processes. However, its efficacy and safety in treating ...
Aims Dedicator of cytokinesis 2 (DOCK2), a member of the DOCK family of guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown. Methods and results Using mice ...
Aims Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size and adverse cardiac remodelling. We determined by cardiac ...
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IMPACT FACTOR
10.4
CARDIAC & CARDIOVASCULAR SYSTEMS
11 out of 222
JOURNAL CITATION INDICATOR
2.62
CARDIAC & CARDIOVASCULAR SYSTEMS
12 out of 222
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Dr Costantino Iadecola, as a physician-scientist, first spoke about why he focused on neurobiology as a specialization. During his medical course (Sapienza University of Rome), he was obsessed in studying human physiology, discovering the brain as one of the most complex and fascinating aspects of biology. Then, he decided ...
The authors thank Liz Coyle, University of Glasgow, for assistance with the preparation of this article. None. No new data were generated or analysed in support of this research. Katarzyna Stefanska, BMedSci, is an undergraduate MBChB (Hons) student at the University of Edinburgh, currently in her clinical years. She is ...
Cardiovascular disease remains the leading cause of morbidity and mortality globally despite significant strides in prevention and treatment. Accurate risk prediction is crucial for early intervention and effective management of cardiovascular conditions, which can ultimately reduce the burden of disease and healthcare ...
Students derive inspiration from this historical knowledge and realize that it can be rewarding to challenge long-standing theories with the right arguments. 2 Research and discovery are continuous processes, often involving counterintuitive observations and the realization that the scientific ‘truth’ needs to be ...
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