Advance articles
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Research Article 29 April 2025
Abdominal aortic aneurysm histomorphology shows different inflammatory aspects among patients and is not associated with classic risk factors – the HistAAA study
Maja Carina Nackenhorst and othersCardiovascular Research, cvaf071, https://doi.org/10.1093/cvr/cvaf071 -
Research Article 24 April 2025
Distinct intracellular spatiotemporal expression of Calmodulin genes underlies functional diversity of CaM-dependent signaling in cardiac myocytes
Vladimir Bogdanov and othersCardiovascular Research, cvaf059, https://doi.org/10.1093/cvr/cvaf059 -
Research Article 24 April 2025
A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodeling
Feiya Li and othersCardiovascular Research, cvaf058, https://doi.org/10.1093/cvr/cvaf058 -
Research Article 24 April 2025
Identification of pulmonary artery stiffening due to left heart disease by ultrasonography
Mariya M Kucherenko and othersCardiovascular Research, cvaf066, https://doi.org/10.1093/cvr/cvaf066 -
Research Article 24 April 2025
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms
Lucilla Giammarino and othersCardiovascular Research, cvaf074, https://doi.org/10.1093/cvr/cvaf074 -
News 23 April 2025
Sleep protects the heart after myocardial infarction through a neuro-immune axis: time to implement healthy sleep for cardiovascular prevention?
Fabrizia Bonacina and Daniela CarnevaleCardiovascular Research, cvaf073, https://doi.org/10.1093/cvr/cvaf073 -
News 23 April 2025
Unravelling inflammation: the critical role of ETS2 in macrophage activation and chronic disease
Soumaya Ben-Aicha and Gustavo RamosCardiovascular Research, cvaf072, https://doi.org/10.1093/cvr/cvaf072 -
Research Article 18 April 2025
Integrated proteomics identifies troponin I isoform switch as a regulator of a sarcomere-metabolism axis during cardiac regeneration
Timothy J Aballo and othersCardiovascular Research, cvaf069, https://doi.org/10.1093/cvr/cvaf069 -
Research Article 18 April 2025
Enhanced intracranial aneurysm development in a rat model of polycystic kidney disease
Anne France Cayron and othersCardiovascular Research, cvaf063, https://doi.org/10.1093/cvr/cvaf063 -
Review Article 18 April 2025
Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health
Tongyao Zhang and othersCardiovascular Research, cvaf068, https://doi.org/10.1093/cvr/cvaf068 -
Research Article 17 April 2025
Combined circulating microRNA and peptide biomarkers for prognostication in heart failure
Lee Lee Wong and othersCardiovascular Research, cvaf065, https://doi.org/10.1093/cvr/cvaf065 -
Research Article 17 April 2025
Loss of MRAP2 in MC4R neurons protect from obesity-associated autonomic and cardiovascular dysfunctions
Deng Fu Guo and othersCardiovascular Research, cvaf067, https://doi.org/10.1093/cvr/cvaf067 -
Editorial 17 April 2025
Spinning the web of platelet tetraspanins under stress
Madhumita ChatterjeeCardiovascular Research, cvaf062, https://doi.org/10.1093/cvr/cvaf062 -
Editorial 17 April 2025
Revivifying research on relaxin receptor-targeted therapy for cardiovascular diseases
Xiao-Jun DuCardiovascular Research, cvaf057, https://doi.org/10.1093/cvr/cvaf057 -
Editorial 17 April 2025
It is all c-RELative: a new perspective for a member of the nuclear factor kappa B family
Jonathan O’Connor Miranda and othersCardiovascular Research, cvaf053, https://doi.org/10.1093/cvr/cvaf053 -
Review Article 16 April 2025
The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction
Carolina Janssen-Telders and othersCardiovascular Research, cvaf056, https://doi.org/10.1093/cvr/cvaf056 -
Research Article 10 April 2025
Beta 2 adrenergic receptor gene methylation activates innate lymphoid cells to drive hypertension in lymphocyte deficient hosts
Wei Chen and othersCardiovascular Research, cvaf042, https://doi.org/10.1093/cvr/cvaf042 -
Editorial 7 April 2025
Mimicked immunity: a strategy for targeted nanodrug delivery
Yapei Zhang and othersCardiovascular Research, cvaf050, https://doi.org/10.1093/cvr/cvaf050 -
Research Article 4 April 2025
Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy
João P Monteiro and othersCardiovascular Research, cvaf043, https://doi.org/10.1093/cvr/cvaf043 -
Editorial 3 April 2025
Keep your guard up: blood–brain barrier protection by empagliflozin after acute ischaemic stroke
Karin Hochrainer and othersCardiovascular Research, cvaf049, https://doi.org/10.1093/cvr/cvaf049 -
Research Article 2 April 2025
Pre-ischaemic empagliflozin treatment attenuates blood–brain barrier disruption via β-catenin mediated protection of cerebral endothelial cells
Guohao Liu and othersCardiovascular Research, cvaf026, https://doi.org/10.1093/cvr/cvaf026 -
Research Article 2 April 2025
Endothelial insulin-like growth factor-1 signalling regulates vascular barrier function and atherogenesis
Michael Drozd and othersCardiovascular Research, cvaf055, https://doi.org/10.1093/cvr/cvaf055 -
Editorial 27 March 2025
A paradigm shift in cardiovascular research: new method isolates intestinal interstitial fluid to understand gut microbiome and host cross-talk
Fadi J Charchar and Francine Z MarquesCardiovascular Research, cvaf047, https://doi.org/10.1093/cvr/cvaf047 -
Editorial 24 March 2025
It takes more than omics to identify a cardioprotective mechanism
Gerd Heusch and Petra KleinbongardCardiovascular Research, cvaf052, https://doi.org/10.1093/cvr/cvaf052 -
Research Article 24 March 2025
Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis
Marcin A Sowa and othersCardiovascular Research, cvaf051, https://doi.org/10.1093/cvr/cvaf051 -
Research Article 21 March 2025
Beneficial effects of vascular endothelial growth factor B gene transfer in the aged heart
Nivethitha Manickam and othersCardiovascular Research, cvaf046, https://doi.org/10.1093/cvr/cvaf046 -
Editorial 21 March 2025
From mice to humans: advancing the path to cardioprotection
Lina Badimon and othersCardiovascular Research, cvaf048, https://doi.org/10.1093/cvr/cvaf048 -
Research Article 19 March 2025
Biologically engineered valved conduits for right ventricular outflow tract repair evaluated for 52 weeks in growing lambs
Zeeshan H Syedain and othersCardiovascular Research, cvaf038, https://doi.org/10.1093/cvr/cvaf038 -
Review Article 18 March 2025
Upfront lipid-lowering combination therapy in high cardiovascular risk patients: a route to effective atherosclerotic cardiovascular disease prevention
Maciej Banach and othersCardiovascular Research, cvaf045, https://doi.org/10.1093/cvr/cvaf045 -
Research Article 15 March 2025
Protective functions of liver X receptor α on calcified aortic valve: involvement of regulating endoplasmic reticulum-mediated osteogenic differentiation
Lishan Zeng and othersCardiovascular Research, cvaf044, https://doi.org/10.1093/cvr/cvaf044 -
Review Article 14 March 2025
Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
Sean M Davidson and othersCardiovascular Research, cvaf023, https://doi.org/10.1093/cvr/cvaf023 -
Editorial 13 March 2025
Unveiling the role of tyrosine kinases in doxorubicin-induced cardiotoxicity and beyond
Edoardo Lazzarini and othersCardiovascular Research, cvaf035, https://doi.org/10.1093/cvr/cvaf035 -
Research Article 13 March 2025
Cardiac ischaemia/reperfusion in pigs and mice increases cardiomyocyte Krüppel-like factor 5 that aggravates tissue injury and remodelling
Nikolaos Mylonas and othersCardiovascular Research, cvaf040, https://doi.org/10.1093/cvr/cvaf040 -
Research Article 5 March 2025
Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function
Selvi Celik and othersCardiovascular Research, cvaf037, https://doi.org/10.1093/cvr/cvaf037 -
Research Article 5 March 2025
Targeted delivery of TAPI-1 via biomimetic nanoparticles ameliorates post-infarct left ventricle function and remodelling
Qing Chen and othersCardiovascular Research, cvaf039, https://doi.org/10.1093/cvr/cvaf039 -
Research Article 4 March 2025
Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation
Silke Griepke and othersCardiovascular Research, cvaf032, https://doi.org/10.1093/cvr/cvaf032 -
Editorial 3 March 2025
Novel role of vascular smooth muscle cell-expressed METTL3 in atherosclerosis
Joanna Stuck and Islam OsmanCardiovascular Research, cvaf036, https://doi.org/10.1093/cvr/cvaf036 -
Research Article 3 March 2025
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction
Monika Papworth and othersCardiovascular Research, cvaf031, https://doi.org/10.1093/cvr/cvaf031 -
Research Article 28 February 2025
Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium
Eline Huethorst and othersCardiovascular Research, cvaf034, https://doi.org/10.1093/cvr/cvaf034 -
Research Article 28 February 2025
Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination
Dan Yang and othersCardiovascular Research, cvaf033, https://doi.org/10.1093/cvr/cvaf033 -
Review Article 28 February 2025
Anti-senescence therapies: a new concept to address cardiovascular disease
Stevan D Stojanović and othersCardiovascular Research, cvaf030, https://doi.org/10.1093/cvr/cvaf030 -
Editorial 28 February 2025
Cardiomyocyte-derived fibrosis as driver of cardiomyopathy
Abel Martin-Garrido and Joerg HeinekeCardiovascular Research, cvaf025, https://doi.org/10.1093/cvr/cvaf025 -
Research Article 24 February 2025
The Mediterranean diet displays an immunomodulatory effect that correlates with beneficial changes in carotid atherosclerosis
Ana Maria Ruiz-Leon and othersCardiovascular Research, cvaf027, https://doi.org/10.1093/cvr/cvaf027 -
Research Article 24 February 2025
Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients
Aida Llucià-Valldeperas and othersCardiovascular Research, cvaf028, https://doi.org/10.1093/cvr/cvaf028 -
Research Article 21 February 2025
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways
Blanca Tardajos Ayllon and othersCardiovascular Research, cvaf024, https://doi.org/10.1093/cvr/cvaf024 -
Research Article 20 February 2025
Methyltransferase-like 3–catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis
Zhigang Dong and othersCardiovascular Research, cvaf029, https://doi.org/10.1093/cvr/cvaf029 -
Research Article 18 February 2025
Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction
Takaomi Suga and othersCardiovascular Research, cvaf022, https://doi.org/10.1093/cvr/cvaf022 -
Research Article 17 February 2025
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition
Louk T Timmer and othersCardiovascular Research, cvaf021, https://doi.org/10.1093/cvr/cvaf021 -
Letter 13 February 2025
Angiotensin 1-7 and a telomerase reverse transcriptase activator individually restore vasodilatory capacity within the human microcirculation previous SARS-CoV-2 infection
Yoshinori Nishijima and othersCardiovascular Research, cvaf020, https://doi.org/10.1093/cvr/cvaf020 -
Letter 11 February 2025
Emerging role of Cellular communication network factor 2 as a guardian of smooth muscle cell phenotype and vascular integrity
Jannik Hjortshøj Larsen and Lasse Bach SteffensenCardiovascular Research, cvaf015, https://doi.org/10.1093/cvr/cvaf015