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A sequential and continuous-flow synthesis of cefazolin was achieved without intermediate isolation, yielding 54% isolated yield and 13.75 g/h dL STY at 0.3 mol/h scale. The flexible system design worked on various scales, and the obtained material had an acceptable impurity profile and purifiable by simple procedures into the essential antibiotics.

A single fullerene molecule shuttling, rotating, and interacting with a vibrating carbon nanotube was visualized using an electron microscope, a fast camera, and a denoising algorithm. We have thus realized high spatiotemporal precision, and revealed the rich molecular dynamics, where the mechanical motions are non-linear, stochastic and non-repeatable.

An automated microarray diagnostic system for SARS-CoV-2 protein-specific antibodies was developed. Photoimmobilization strategy was used to immobilize proteins by crosslinking reactions of photoreactive polymers. The microarray assay showed higher sensitivity than the conventional immune chromatography. The microarray format was useful for rapid serodiagnosis of viral infectious diseases and assessment of immune status for clinical applications.

Alkylene and arylene bis(fluoroalkyl) bis(carbonate)s (BFBCs) were quantitatively synthesized through base-catalyzed fluoroalkyl carbonate esterification of diols with bis(fluoroalkyl) carbonates (BFCs). Non-isocyanate polyurethane (NIPU) synthesis was then achieved without a catalyst through polycondensation reactions of BFBCs and a series of diamines in solvent or solvent-free conditions.

For use as an electrode material, a new synthetic route to a Martin-type tridentate ligand and hypervalent sulfur anions bearing this ligand has been developed. A battery containing the anions bearing Li + as a counter-cation shows a stable cycle performance, indicating their utility for ...

Quantitative mechanochemical CO2 methanation using H2O mediated by collision and friction of stainless steel balls proceeded without external heating. The formation of metal carbonate as a reaction intermediate was revealed with XPS analysis. The metal carbonate was hydrogenated by H2in situ generated from H2O to methane.

A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including Dl -2,4,6-tridemethyl-3-deoxymethynolide.

It has been established that dihalodiphosphinenickel(II) complexes exhibit extremely high catalytic activity for selective cross-coupling of Grignard reagents with aryl and alkenyl halides. This catalytic reaction can be employed in synthetic practice for reasons of simple procedures, mild reaction ...

We developed facile synthesis of quinoline-based PNN ligands. The reactions of a PNN ligand and iron salt exclusively gave the mono-chelated PNN complex or bis-chelated complex depending on the substituent of phosphorus atom or iron salts.

Free-standing conductive polymeric nanosheets consisting of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) and polystyrene-block-polybutadiene-block-polystyrene layers were fabricated by roll-to-roll processing method. The conductive nanosheets were used as “nanosheet electrodes” for the biopotential measurement of plant leaves, which realized minimally invasive biopotential measurement of plant leaves.

Heat-stable enterotoxins, produced by various enteric bacteria such as enterotoxigenic Escherichia coli , Yersinia enterocolitica , and Vibrio cholerae non-01, have common segments consisting of 13 amino acid residues (T. Takao et al., FEBS Lett. , 193 , 250 (1985)). These segments have full ...

When n -valeric acid was treated with allyl diethyl phosphite and diethyl azodicarboxylate, allyl valeriate and diethyl N -(diethyl)phosphoryl hydrazodicarboxylate were obtained in good yields. Similarly ethyl benzoate was obtained in a nearly quantitative yield by the reaction of benzoic acid with ...

We have now found that molybdenum–iodide complexes bearing a PNP-pincer ligand have a higher catalytic activity than the so far reported molybdenum–dinitrogen complexes for ammonia formation from nitrogen gas under ambient reaction conditions, up to 830 equiv being produced based on a dinitrogen-bridged dimolybdenum complex (415 equiv of ammonia based on the molybdenum atom).

2,4,6-Trimethylphenol was effectively oxidized to trimethyl- p -benzoquinone with molecular oxygen in the presence of a catalytic amount of copper(II) chloride–amines in alcohol at ambient temperature. Various amines could be used as a co-catalyst in the presence of acids, and especially ...

Enantiomerically pure L-BPA (4-borono-L-phenylalanine) was synthesized from L-tyrosine or 4-iodo-L-phenylalanine derivatives using the palladium-catalyzed cross-coupling reaction of pinacolborane (2,3-dimethyl-2,3-butanediolatoboron). Cbz-Tyr(Nf)-OBzl ( 2b ) underwent the cross-coupling reaction ...

Anhydroyplyaspartic acid (APAA) was prepared by the thermal polycondensation of l -aspartic acid in the solid state at 160-220 °C for 5 h. The effect of temperature on molecular weight and optical purity of APAA was investigated. The molecular weight increases rapidly in the temperature range ...

A molecular field analysis using computational-screening data and the corresponding transition-state structures with a relatively small dataset (30 samples) enabled the regression-based data-driven design of chiral NHC ligands with improved enantioselectivity for the Cu-catalyzed carbonyl addition of a silylboronate.

Three nitrile oxides (MeOCOC≡N→O, PhC≡N→O, and EtC≡N→O) were effectively generated in situ by dehydration of the corresponding primary nitro compounds (RCH 2 NO 2 ) with PhSO 2 Cl or ClCOOEt in the presence of triethylamine. Various cycloadducts were prepared by the reaction of them with ...

Noteworthy results regarding the photoluminescence properties of Eu(III) complexes 1 and 2 with thienyl groups show that quantum yields have strong positive linear correlations with concentration in ethyl acetate, and those in the solid state are located on an extended line. This means that no concentration quenching is observed.

Benzyl radicals were generated from acetals via low-valent titanium-mediated homolytic C–O bond cleavage, and were subjected to radical conjugate addition. Owing to the low cost and availability of the developed titanium reagent, the methodology provides efficient access to α-alkoxy benzyl radical species. Unstable ketal substrates also afforded conjugate addition products in acceptable yields.

It has been revealed that structural information to improve enantioselectivity in asymmetric catalysis can be extracted and visualized through a regression technique, Molecular Field Analysis (MFA). A molecule designed based on the visualized structural information exhibited higher enantioselectivity than those in the training set.

The Pd- or Ni-catalyzed cross-coupling reactions of organometals containing Zn, Al, Zr, and B as well as related reactions of Mg and several other metals collectively represent the most widely applicable organic skeleton construction method discovered and developed over the past several decades, ...

A new halogenated C 15 nonterpenoid with a novel carbon framework, named notoryne, has been isolated from the title alga and its structure was established on the basis of spectroscopic and chemical evidence. In addition, the structure of a rearranged product, whose structure has long remained ...

The first total synthesis of lyconesidine B, which is a fawcettimine-type lycopodium alkaloid containing an oxygenated amine-type core, was achieved. The keys were the construction of the CD ring decahydroquinoline via cyclopropanation followed by ring-opening and reduction, and the AB ring tetracyclic core by ene-yne metathesis of a quaternary ammonium salt. We also investigated the asymmetric cyclopropanation using chiral Ru catalysts.

cis -β-Alkoxystyrenes such as cis -β-methoxy-, cis -β-ethoxy-, and cis -β-isopropoxystyrene were autoxidized as neat at room temperature in the dark even in the absence of any radical generator. UV-irradiation and the use of a radical generator facilitated the oxygenation of these olefins. These ...

FAU–CHA interzeolite conversions were investigated in the presence of benzyltrimethylammonium hydroxide (BTMAOH) and 1-adamantyltrimethylammonium hydroxide (AdaTMOH) as organic structure-directing agents (OSDAs). AdaTMOH was well able to both decompose/dissolve the starting FAU-type zeolites into ...

A concentrated fraction of highly unsaturated acids was separated from sardine oil by means of sodium-soap-acetone method, and was distilled as its methyl esters up to 215°/2 mm. The residue from the distillation consisted mainly of the methyl esters of highly unsaturated C 24 -acids and some ...

Ladder-type heteroacenes based on indolodibenzothiophene have been synthesized. The route involved a regioselective twofold intramolecular acid-induced cyclization of the central bis(butylsulfinyl)phenyl unit onto the adjacent carbazole units, followed by dealkylation to give ...

For the purpose of synthesizing daphnezomine C, model systems were examined to see if the ring-closing metathesis (RCM) reaction could be applied to prepare an 11-membered ring system bearing a tri-substituted alkene. As a result, it was found that the connectivity pattern of the tethers bearing ...

The reactions of iodobenzene with azole compounds, 1,2-disubstituted imidazoles and 2-substituted oxazoles and thiazoles, were examined in the presence of catalytic amounts of Pd(OAc) 2 and PPh 3 in DMF using alkali metal carbonates as bases. It was found that the coupling products, 5-arylazoles, ...

The reaction of azine-thiones with ethyl chlorofluoroacetate afforded 2-fluorothienoazines. The latter underwent self-condensation and gave multi-fused heterocyclic compounds. A wide range of unique heterocycles could be obtained on treatment of 2-fluorothienoazines with nitrogen nucleophilic ...

5-Hydroxymethyl-2-furfural ( 2a ) was formed in a 70% yield by dehydration of glucose in MeCN at 140 °C in an autoclave using a composite of MgCl 2 with silica gel which served as an acid catalyst under dry conditions. 10% and 32% yields of 2a were obtained from mannose and galactose, respectively.

In order to explore the oxidation mode of lipoxygenase (LOX) obtained from infected rice plants, typical unsaturated fatty acids ( 3 — 8 ) were treated with LOX and oxygen. It was observed that ω -10 and ω -6 positions of unsaturated fatty acids were oxidized predominantly in the cases of exotic ω ...

Dl - cis -β-phenylglycidic acid was resolved using (−)-ephedrine. The configurations of α- and β-carbons of the resolved cis -(+)-glycidic acid were determined by oxydative and hydrogenolytic reactions.

The Rössing’s reaction of 4-substituted 2-acylphenoxyacetic acids give a mixture of benzofurans and 2-benzofurancarboxylic acids. The relative yields of benzofurans and 2-benzofurancarboxylic acids depend on the substituents on the benzene ring of the 2-acylphenoxyacetic acids. Electron-withdrawing ...

A novel synthesis of carbamate ester using carbon dioxide as a direct material is reported in this article. The direct reaction of carbon dioxide, aliphatic amines, and alkyl halides was found to give the corresponding alkyl carbamate esters in good yields. Reactions using secondary alkyl bromides ...

The reaction of 2′-hydroxy-4-methoxy-3′,5′-dimethylchalcone with anhydrous AlCl 3 in benzene gave three kinds of crystals having different melting points. It is concluded that the crystals are three modifications of 7-hydroxy-3-( p -methoxyphenyl)-4,6-dimethyl-1-indanone on the basis of their mutal ...

The in situ -generated nickel(0) species, presumably atomic nickel, from nickel(II) salt and zinc powder has been proved to be an effective catalyst for the Finkelstein-type displacement reaction of aryl bromides with potassium iodide to give aryl iodides under mild conditions. This species was ...

The chemical conversions of natural polymyxin B and colistin, which are fatty-acylated cyclic decapeptides, to polymyxin (2–10) and colistin (2–10) derivatives were examined. The N α -free and side chain N γ -protected nonapeptides, i.e., tetrakis( N γ -trifluoroacetyl)–polymyxin B (2–10) and ...

To elucidate the N -terminal structure–activity relationships of polymyxin B peptides, seven polymyxin B component peptides, the structures of which having been elucidated, and seven N -terminal fatty acid and/or amino acid deletion analogs were synthesized, and their antimicrobial activities ...

Gene therapy by introducing a foreign DNA into a cell with defective gene has been expected to treat various incurable diseases such as cancers, inherited diseases, and cardiovascular disease. Cationic lipids have been used as a carrier of therapeutic DNAs because they can form a complex with DNA ...

SiO 2 -coated Al 2 O 3 powders were prepared by depositing hydrolyzed tetraethoxysilane (TEOS) on Al(OH) 3 and γ-Al 2 O 3 at 40 °C. In the preparation using Al(OH) 3 with a specific surface area ( SA ) of ca. 40 m 2 g −1 as a support, loading of silica deposited on the Al(OH) 3 was saturated at 80 ...

It was found that a cyclized product containing one nitrogen atom could be obtained by the reaction of ethyl cyanoacetate with various ketones in the presence of excessive ammonium acetate. On the basis of this experiment, pyridone derivatives such as ...

A novel hemin-binding DNA was synthesized using in vitro selection (SELEX) method. The selected DNA not only bound to the hemin, but also had peroxidase activity when complexed with hemin. A pool of 104-nt single-stranded DNA (ssDNA) molecules containing a randomized sequence of 60 nt was ...

Iron(I)– and iron(0)–dinitrogen complexes supported by anionic benzene-based PCP- and POCOP-type pincer ligands as carbon donors are synthesized to catalyze the formation of ammonia and hydrazine from dinitrogen (1 atm), producing up to 252 equiv of ammonia and 68 equiv of hydrazine (388 equiv of fixed N atom) based on the iron atom of the catalyst.

The concept and representative examples of “element-block polymers” are described. A structural unit consisting of various groups of elements is called an “element-block.” In this review, unique properties of “element-block polymers” composed of organoboron complexes, o -carboranes, and polyhedral ...

The present paper reports development of new thermally activated delayed fluorescence (TADF) molecules with the acridan–triazine structure substituted by perfluoroadamantyl (Ad F ) groups. The Ad F group was prepared by perfluorination using fluorine gas, and introduced into the molecules via ...

A disubstituted cyclopentenone (2) was produced from 2-deoxy-d-glucose (1) by a facile method, catalyst-free hydrothermal reaction. In addition, the reaction mechanism under hydrothermal treatment was elucidated. As one example of applicability to the preparation of high value chemicals, the synthesis of prostaglandin E1 methyl ester (9) was demonstrated from (R)-2.

Understanding the mechanism of conformational/configurational isomerism of sterically congested alkenes is of great importance to develop novel molecular response systems. Herein, through the careful study on overcrowded anthraquinodimethane (AQD) derivatives including unsymmetrical compounds, we found AQD ring-flip is the key process to make stimuli-responsive materials with multi-conformational/multi-configurational isomers enabling the switching of their structures and physical properties.

Liquid interfaces are unique environments in which a variety of fundamental phenomena occur. Therefore, it is important to obtain a molecular-level understanding of liquid interfaces for both basic science and industrial applications. However, it is not an easy task to investigate molecules in the ...

Time-resolved visible and ultraviolet resonance Raman spectroscopy were used to determine conformational dynamics upon an external stimulus and energy flow with a spatial resolution of a single amino acid residue in proteins. This account summarizes the accomplishments that promoted an understanding of how proteins change structure to realize their functions and how energy dissipation is coupled to protein structure and dynamics.

The crystal structure of bis(adiponitrilo)-copper(I) nitrate has been determined by the two-dimensional Fourier method. It is orthorhombic Pnnn with two formula units in a cell of dimensions: a =9.41±0.02 Å, b =13.73±0.02Å and c =5.85±0.01 Å. The crystal consists of infinite three-dimensional ...

A new method of obtaining the kinetic parameters from thermogravimetric curves has been proposed. The method is simple and applicable to reactions which can not be analyzed by other methods. The effect of the heating rate on thermogravimetric curves has been elucidated, and the master curve of the ...

MAIRS is a rapidly being spread as a powerful tool for analyzing the molecular structure in a functionalized thin film in terms of molecular orientation, conformation and polymorph in a quantitative manner. Since MAIRS analysis is uniquely robust to the surface roughness of the film, all kinds of thin films prepared by the spin-coating and drop-casting can be analyzed with a high reproducibility.

Metal halide perovskite semiconductors are excellent materials for next-generation solar cells. As a result of research and development all over the world, the photoelectric conversion efficiency for single-cell devices has rapidly improved to over 26% (as of July 2023), while the record efficiency ...

It was found that oxidation potentials of methanes with π-electron substituents were decreased by introduction of a trimethylsilyl group. The anodic oxidation of benzyl-, allyl-, aryl(or alkyl)thiomethyl-, and aryloxymethyl-substituted trimethylsilanes smoothly proceeded in the presence of ...

In this study, borylated-conjugated trienes were synthesized by Ru-catalyzed cross-dimerizations for use in cross-coupling reactions. A series of mono- and diborylated-conjugated trienes were synthesized by cross-dimerization and assessed for their potential use in cross-coupling reactions. Using this protocol, the total synthesis of navenone B, a sea slug pheromone, was achieved in only three steps in 45% total yield.

A number of hexaphenyl[3]radialene derivatives were synthesized in modest to good yields by the reaction of tetrachlorocyclopropene with diarylmethyl anion followed by oxidation with oxygen. That the acidity of diarylmethane is higher than that of diphenylmethane is found to be an important factor ...

The binding energies of N(1s) in ethylenediaminetetraacetic acid (EDTA) and its related compounds were measured by means of a photoelectron spectrometer, and the molecular structures of EDTA were discussed. Two kinds of peaks were observed in the N(1s) spectra of EDTA and its related compounds, ...

Ultrasonic irradiation of α,β-unsaturated carbonyl compounds 1a–i with acetonitrile in the presence of potassium t -butoxide gave 3-cyano-2-methylpyridines 2a–i in moderate to good yields. The pyridines are produced by a Michael reaction of 3-iminobutanonitrile, an acetonitrile dimer, to the ...

trans -5-Aryl and 5-cyclopropyl derivatives of 2-isoxazolin-4-ol were conveniently prepared from trans -2-aryl- and 2-cyclopropyl-3-benzoyloxiranes and hydroxylamine hydrochloride in the presence of pyridine via an intramolecular opening of oxirane by the oxygen nucleophile of the oxyimino group.

The compounds of a new type, 2,2′-bibenz-1,3-oxazine and its derivatives have been synthesized by the reactions of salicylamines with glyoxal or α-diketones in methanol at a temperature lower than 20°C. The oxazine structures were confirmed by infrared spectroscopy in solid state and by NMR ...

Photophysical properties of flapping peryleneimide were compared with those of representative molecular rotors, DCVJ and BODIPY as well as flapping anthraceneimide. Flapping peryleneimide showed extremely high photostability and more sensitive fluorescence response in a low viscosity range (0.3–3.1 cP), which enables discrimination of different n-alkanes by the fluorescence lifetime measurement.

The mixed liquid acids obtained from the sample oil by cooling were converted into methyl esters which were fractionally distilled under a diminished pressure of 4 mm. From the highest boiling fraction, the authors separated a new highly unsaturated acid C 26 H 40 O 2 (( Remark: Graphics omitted. ) ...

The chemical and physical characteristics of a sample of the oil of “Hokke” ( pleurogrammus monopterygius , Pallas) have been determined. In the investigation of higher fraction and distillation residue, the authors have recognized the probable existences of highly unsaturated fatty acids of higher ...

Arjungenin, a new triterpene isolated from Terminalia arjuna , is shown to be 2α,3β,19α,23-tetrahydroxyolean-12-en-28-oic acid ( 1 ). The structures of two new triterpene glucosides, arjunglucoside I and arjunglucoside II, isolated from the same plant, were determined to be β- d -glucopyranosyl ...

The structure of a new triterpene glucoside, arjunglucoside III, isolated from Terminalia arjuna was found to be β- d -glucopyranosyl 2α,3β,19α-trihydroxy-11-oxoolean-12-en-28-oate.

A series of 2,2′-di(heteroaryl)-9,9′-spirobifluorenes were prepared by employing Friedländer reaction of 2,2′-diacetyl-9,9′-spirodifluorene with a series of ortho -aminoarenecarbaldehydes. The compound 2,2′-di(benzo[ b ]-1,10-phenanthrolin-2-yl)-9,9′-spirofluorene ( 4e ) showed a green light ...

We established a strategy to obtain atroposelective antibodies for each enantiomer of a binaphthyl derivative (BN) with a single immunization. Anti-BN mAbs also recognize the chirality of binaphthyl derivatives other than BN.

Aminoacetonitrile sulfate was heated with kaolin and/or Japanese acid clay at 120∼140°C for 5 hr. The presence of glycyl-glycine and glycyl-diglycine in the extract and the partial hydrolysate of this reaction product was confirmed by paper and column chromatography.

Transamination reactions in the presence of zinc(II) ion between ( R )- or ( S )-15-aminomethyl-14-hydroxy-5,5-dimethyl-2,8-dithia[9](2,5)pyridinophane, pyridoxamine analog with planar chirality, and o -, m -, and p -fluorophenylpyruvic acids or o -, m -, and p -(trifluoromethyl)phenylpyruvic acids ...

Mesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and ...

Nowadays a wide variety of synthesis techniques are utilized to produce nanoporous materials. In this review, we summarize the general principles of templated synthesis using various types of templates and cover recent developments in this area.

Reaction of several divalent organic sulfur compounds with copper(II) chloride in acetonitrile gave the corresponding disulfides or other polysulfides in good yields under mild conditions.

The synthesis route of 10Al 2 O 3 ·2B 2 O 3 (10A2B) and effect of additives were studied to use this compound as a thermally stable support material for Pd catalysts. The preparation by reverse coprecipitation was found to have a beneficial effect on the BET surface area of 10A2B and thus Pd metal ...

Hydroxy-substituted organic molecules were used as target molecules in investigations of the role of the reagent structure on the reactivity of three types of N–F class fluorinating reagents: 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) F-TEDA ( 1a ), N ...

( Z )-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-[(fluoromethoxy)imino]acetic acid ( 2 ), a useful chemical modifier of cephalosporin antibiotics, was efficiently synthesized from 2-[(fluoromethoxy)imino]-1,3-propanedinitrile. The stereochemical structure of 2 was unambiguously determined by X-ray ...

Both potentionmetric and spectrophotometric measurements have been carried out in order to study the chelating tendencies of catechol-4-sulfonate with iron (III) ions in aqueous media at the ionic strength of 0.10 m . Even in the 3:1 (ligand to metal ion) system, the equilibrium of the titrating ...

Reduced PQQ (PQQH 2 ) is prepared by the reaction of PQQ with thiophenol, 1-benzyl-1,4-dihydronicotinamide (BNAH), sodium dithionite, or sodium borohydride. Oxidation of PQQH 2 to PQQ by molecular oxygen in aqueous solutions is investigated kinetically. The oxidation is accelerated gradually with ...

Oligocytidylates upto a pentamer were prepared by lead(II) ion catalyzed polymerization of cytidine 5′-phosphorimidazolide in aqueous solution. 2′–5′ internucleotide linkage was preferentially formed. The yields of the 2′–5′ linked dimer, trimer, tetramer and pentamer were 17.0, 5.5, 1.9, and 0.7%, ...

Hydrogenations of bisphenol A (I) over Raney nickel (W-1) and Urushibara nickel A and B have been carried out, and three stereoisomers of 2,2-bis(4-hydroxycyclohexyl)propane (II) and two of 2-(4-hydroxycyclohexyl)-2-( p -hydroxyphenyl)propane (III) have been isolated from the products. The ...

The effect of substituents on the double bond of α , β -unsaturated ketones for the 1,4-addition reaction rate of alkenylboronic acids induced by cyanuric fluoride was studied in detail. When the steric hindrance around the β -carbon of the unsaturated ketones increased, the 1,4-addition reaction ...

A lipophilized gramicidin S (GS) analog was synthesized by introducing l -α-aminomyristic acid (Amy) residues instead of l -leucine residues by the conventional solution method. Influences of lipophilization of GS on interaction with phospholipid liposomes were examined by the peptide-induced ...

We have examined the synthesis of cyclic oligomers with pendant norbornadiene (NBD) moieties based on the calixarenes [ p - tert -butylcalix[8]arene (BCA), p -methylcalix[6]arene (MCA), calix[4]resorcinarene (CRA), 2,8,14,20-tetradecylcalix[4]resorcinarene (CRA 10 ), and 2,8,14,20-tetrakis( p ...

Selective formation of formic acid, oxalic acid, and carbon monoxide by electrochemical reduction of carbon dioxide (CO 2 ) is demonstrated using several metallic electrodes in aqueous and nonaqueous electrolytes. The electrode metals catalyze the electrochemical reduction of CO 2 and are ...

The concentration profile and particle size of nickel supported on alumina spheres were easily controlled by varying the starting source materials of the impregnation solution. Further, the reduction behavior of nickel oxide supported on alumina was influenced by the starting nickel source material.

Oxygenation of copper(I) with tetradentate tripodal ligands (L) comprised of a tris(aminoethyl)amine (tren) skeleton having sterically bulky substituent(s) on the terminal nitrogens has been investigated, where L = tris( N -benzylaminoethyl)amine (L H,Bn ), tris( N -benzyl- N ...

A catalytic system consisting of sodium tungstate dihydrate, (aminomethyl)phosphonic acid, and methyltrioctylammonium hydrogensulfate, effects the epoxidation of olefins using 30% hydrogen peroxide with a substrate-to-catalyst molar ratio of 50—500. The reaction proceeds in high yield without ...

The compound IVb named in the title has been obtained by an unambiguous route. It has been shown to be identical with the product of the reaction of the N -oxide (Ia) with ethanolic hydrogen chloride. Clark-Lewis and Katekar’s mechanism for the nucleophilic chlorination in the latter case has been ...

Ruthenium- and rhodium-catalyzed intramolecular C–H/olefin coupling reactions of 1-(2-pyridyl)-, 1-(2-imidazolyl)-, and 1-(2-oxazolyl)-1,5-dienes proceeded in a regiospecific manner to give 5-membered ring products. Their 1,6-diene analogues are also applicable to the cyclization reaction to give ...

Dialkyl ethers and alkyl fluoroalkyl ethers are obtained in excellent yields by the reaction of alcohols and carbonyl compounds in the presence of Pd/C under the atmospheric pressure of hydrogen, when water produced by the reaction is continuously removed by bubbling hydrogen through the reaction ...

Several new pyrazolo[1,5- a ]pyrimidines were synthesized via the reaction of 4,5-disubstituted 3-aminopyrazoles 1a–d with 3-dimethylaminopropiophenone, cinnamaldehyde, benzylideneacetophenone and tetracyanoethylene.

With the intention of achieving the selective ortho -substitution of F -benzoic acid and F -phenol via intramolecular nucleophilic cyclization, preparation of some requisite precursory F -benzoyl- and F -phenoxy compounds and their nucleophilic cyclization reactions were examined. 1,2-( F ...