Abstract

Oligocytidylates upto a pentamer were prepared by lead(II) ion catalyzed polymerization of cytidine 5′-phosphorimidazolide in aqueous solution. 2′–5′ internucleotide linkage was preferentially formed. The yields of the 2′–5′ linked dimer, trimer, tetramer and pentamer were 17.0, 5.5, 1.9, and 0.7%, respectively. Some of their properties were studied by NMR, CD, UV, and chromatography and compared with the corresponding 3′–5′ linked oligomers which were prepared enzymatically.

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