Rapid and Modular Synthesis of Skeletally Diverse Natural Product Analogs by Expansion of Biosynthetic Processes

At the forefront of advanced biomimetic synthetic pathways, our research group transcends traditional single-target synthetic campaigns by developing versatile chemical assembly lines. These transformative synthetic approaches enable the rapid, modular construction of a wide range of structurally diverse natural products and their derivatives. This review primarily addresses two approaches: (1) a chemo-enzymatic synthetic process, and (2) a biogenetically inspired synthesis of skeletally diverse natural products and their variants. Together, these complementary strategies facilitate the development of streamlined modular assembly lines capable of systematically generating "scaffold variations". Our explorations are shaping innovative synthetic tactics that provide rapid, cost-effective, and flexible access to the expansive realm of natural product-relevant chemical space.