... Pathophysiology Research England Policy Support Grant Atrial fibrillation (AF) is the most common cardiac arrhythmia, with prevalence expected to rise exponentially within an ageing population. ¹ The presence of AF is associated with increased risk for cardio-/cerebrovascular mortality...

... the complex pathophysiology of Fontan circulation. The authors highlight two key concepts: ventriculo-arterial coupling and venous return resistance. These principles, indeed, provide a compelling explanation for the dichotomous observations in our study regarding right and left ventricular dominant...

... kidney function [ 7 , 14 ]. Although focusing on one single factor, such as phosphate, does not entirely capture CKD-MBD pathophysiology, it represents a simple conceptual framework to explain how adaptive control of mineral metabolism may turn maladaptive under certain conditions (Fig.  1 ). ABSTRACT...

... pathophysiology through limiting the mucosal establishment of pathobionts such as SFB and the association of such microbe-derived endospores linked to the formation of ectopic tertiary lymphoid organs seen commonly in patients. Graphical Abstract Graphical Abstract inflammatory bowel disease Isoniazid...

... Background Orthostatic hypotension (OH) is an important differential diagnosis in unexplained syncope. Neurogenic OH (nOH) has been postulated to differ from non-neurogenic OH (non-nOH), yet pathophysiological differences are largely unexplored. We aimed to investigate etiology and tilt table test (TTT...

... November 2023 (the most recent searches were Scopus: 6/11, PubMed + Web of Science 7/11, and Ovid 10/11). For a complete search strategy for Medline/PubMed, see Supplementary B . fibrotic plaque pathophysiology preclinical studies stem cell therapy biomolecular effects transforming growth factor (TGF...

... in the pathophysiology, diagnosis, outcome prediction, and management. BK polyomavirus-associated nephropathy diagnosis pathophysiology prognosis treatment Wellcome Trust 10.13039/100010269 223495/Z/21/Z Medical Research Council 10.13039/501100000265 National Institute for Health and Care Research...

... A Libermann; Long H Ngo; Sarinnapha M Vasunilashorn; Roger A Fielding Confusion assessment method Least absolute shrinkage and selection operator Pathophysiology Prediction Surgery National Institute on Aging 10.13039/100000049 R01AG051658 P01AG031720 K24AG035075 K01AG057836 R03AG061582...

... and after 12 months. Results Regarding MRI lesions, Visual rating scales did not show any significance between baseline and follow-up. Conclusion More sophisticated tools are needed to assess radiological progression in CSVD. Cerebral small vessel disease pathophysiology MRI QJM: An International...

... (29%), followed by atrioventricular valve regurgitation (16.7%), a high pulmonary vascular resistance (16.7%), restrictive pathophysiology (16.7%) and obstruction (12.5%). Patients with right ventricular dominance developed most often systolic ventricular dysfunction, while patients with left...

... patients were collected at the central lab of the UMCG. All collected blood samples were centrifuged for 10 min at 2000 g. The serum was stored in 500 µL vials at −20°C, prior to central storage at −80°C. Cardiac amyloidosis ATTR wild-type HFpEF HFmrEF Biomarker Pathophysiology Time of primary review...

... adults associated with increased risk of dementia and death. Understanding the interaction between brain vulnerability and acute stressors is key to delirium pathophysiology, but the neurophysiology of delirium vulnerability is not well defined. This study aimed to identify pre-operative resting-state...

... to measure the surface area for these immune or stromal cell stains. Graphical Abstract Graphical Abstract Paediatrics experimental models pathophysiology Crohn’s and Colitis Foundation CureForIBD Foundation Cincinnati Children’s Center for Stem Cell and Organoid Medicine (CuSTOM...

... Heart Rhythm Society (LAHRS) to contribute to the evolution of the AtCM concept. Atrium Cardiomyopathy Atrial fibrillation Pathophysiology Fibrosis Stroke Mechanisms 1. Background, definition and classification 2. Important recent basic mechanistic insights  2.1. Early-onset atrial...

..., 34 non-frail, and 36 young individuals were evaluated using the Human Magnetic Luminex Screening Assay, performed as a service by Labospace s.r.l. (Milano, Italy). Details in Supplementary Methods . The underlying pathophysiological mechanisms that lead some older adults to develop frailty remain...

... thought to be involved in the pathophysiology of motor symptoms of Parkinson’s disease. The impaired cortical function is believed to be a direct and immediate effect of pathologically patterned basal ganglia output, mediated to the cerebral cortex by way of the ventral motor thalamus. However, recent...

... Vavlukis Despite past successes and collaborations with various ESC bodies, the WG-CPM recognizes the significant challenges in both applied and experimental coronary pathophysiology. Looking ahead, the WG-CPM is dedicated to addressing pivotal research and applied questions in coronary pathophysiology...

... was up-regulated in cases with a median fold change of 3.4 in comparison to healthy controls. Conclusion The studied microRNA can may have a role in pathophysiology of CSVD. Cerebral Small Vessel Disease Pathophysiology Micro-RNA QJM: An International Journal of Medicine, 2024, Vol. 117, Suppl. 1...

... to bacterial pathophysiology, the identification of the heme importers of E. faecalis should be a priority in the field. Like cytochrome bd, both CydC (OG1RF_RS08525) and CydD (OG1RF_RS08530) were found in almost all E. faecalis strains, but not in E. faecium, and most...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized as a heterogeneous syndrome, and there is a growing movement towards...