... best practices, we aim to advance research in this field and provide a foundation for future studies exploring the role of electrical signaling in fungal biology. Electrical signaling in filamentous fungi. electrical signaling modularity filamentous fungi ion channels mycelium In electrophysiology...

... with genome re53 sequencing data for 48 langurs representing 15 Trachypithecus species. Genes coding 54 for ion channels (e.g., Na+, K+, and Ca2+) exhibited significantly accelerated evolution 55 in limestone langurs. Limestone langur-specific mutations in Na+ and Ca2+ channels 56 were experimentally...

... Background Periodontal ligament cells (PDLCs) possess mechanotransduction capability, vital in orthodontic tooth movement (OTM) and maintaining periodontal homeostasis. The study aims to elucidate the expression profiles of mechanosensitive ion channel (MIC) families in PDLCs and how the inflammatory...

... of seizure will improve the identification of potential seizure risks preclinically. In the present study, we evaluated an in vitro panel of 9 investigational (Cav2.1, Cav3.2, GlyRA1, AMPA, HCN1, Kv1.1, Kv7.2/7.3, NaV1.1, Nav1.2) and 2 standard (GABA-A, NMDA) ion channel targets with strong correlative links...

..., such as the smalltooth sawfish), biological features (e.g. size and reproduction, such as for the great white shark and whale shark), and more generally the lack of previous physiological/anatomical studies. vertebrate evolution cartilagious fish genome olfactory receptors TRP ion channels transcriptomics...

... TRP channels. Understanding the interplay between mechanosensors, force-induced signaling cascades, and TRP channels holds promise for the development of targeted therapies for diseases caused by vascular dysfunction. blood pressure endothelial cells hypertension ion channels myogenic tone shear...

... within membrane-bound compartments. C. elegans molting ion channels catp-1 NimA kinases Institutional Development Award (IDeA) National Institute of General Medical Sciences of the National Institutes of Health 2P20GM103432 NIH Office of Research Infrastructure Programs P40...

... can be reversibly suppressed by an inhibitor of MNK signalling. These findings support the development of MNK inhibitors for the treatment of neuropathic pain. ion channels eFT508 human DRG excitability MNK National Institutes of Health 10.13039/100000002 U19NS130608 R01NS065926 R01NS111929...

... the original work is properly cited. Abstract PIEZO2 is a trimeric mechanically-gated ion channel expressed by most sensory neurons in the dorsal root ganglia. Mechanosensitive PIEZO2 channels are also genetically required for normal touch sensation in both mice and humans. We previously showed that PIEZO2...

... of a mutant TRPV4 channel carrying one of the two TRPV4 mutations located in the amino-terminal domain and found in a patient cohort diagnosed with polycystic kidney disease. polycystic kidney disease TRPV4 ion channels PKD kidney disease renal function gain-of-function channelopathies Secretaría de...

... is properly cited. Abstract While voltage-gated potassium channels have critical roles in controlling neuronal excitability, they also have non-ion–conducting functions. Kv8.1, encoded by the KCNV1 gene, is a ‘silent’ ion channel subunit whose biological role is complex since Kv8.1 subunits do not form...

... threshold changes in a group of axons at one nerve site. ¹¹ These threshold changes are dependent on the underlying membrane properties, such as the resting membrane potential, voltage-gated ion channels and pumps. Interpreting the complex set of threshold changes and identifying their specific...

.... as in Eisemann et al. 1984 ; though see Gibbons and Sarlak 2020 and Barrett and Fischer 2024 ). Male mantises may be unable to perceive (minimally) mechanically noxious stimuli, which animals typically perceive using nociceptive ion channels in their peripheral sensory neurons. Eisemann et...

...-based motility, and morphogenesis. ¹ MTs furthermore constitute transportation routes within the cell, trafficking proteins such as ion channels to the plasma membrane. MT function is dynamically regulated by post-translational modifications such as tyrosination/detyrosination, acetylation...

..., and that the work is properly cited. For commercial re-use, please contact [email protected] Abstract Missense variants in calmodulin (CaM) predispose patients to arrhythmias associated with high mortality rates (“calmodulinopathy”). As CaM regulates many key cardiac ion channels, an understanding...

... of Ca²⁺ signals and other molecules such as nitric oxide (NO) and various hormones ( Peláez-Vico et al., 2022 ; Shikha et al., 2022 ). In the past years, an important role of ROS and NO in the regulation of ion channels and transporters of macro- and micronutrients as well...

... the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Chronotropic incompetence Sinoatrial node Heart rate β-Adrenergic receptors Phosphodiesterase Ion channels Canadian Institutes of Health Research 10.13039...

... KH₂PO₄, 137 NaCl, 8 Na₂HPO4-(7H₂O) and was buffered to pH 7.4. Cells were clamped at a holding potential of −90 mV before depolarizing steps appropriate for each ion channel. Currents were measured from the step and referenced to the holding current. Compounds were incubated...

...Carol Ann Remme; Jordi Heijman; Ana M Gomez; Antonio Zaza; Katja E Odening Basic electrophysiology Translational electrophysiology Atrial fibrillation Ventricular arrhythmias Sudden cardiac death Ion channels Pathophysiology Genetics Modelling Several manuscripts investigated...

... and the descriptive ability of models built from such data. Graphical Abstract Graphical abstract Induced pluripotent stem cells Patch clamp Arrhythmias Ion channels Computer simulation National Heart, Lung, and Blood Institute 10.13039/100000050 U01HL136297 F31HL154655 Wellcome Trust 10.13039...