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Alfredo Sanchez Solano, Boris Lavanderos, Elsayed Metwally, Scott Earley, Transient Receptor Potential Channels in Vascular Mechanotransduction, American Journal of Hypertension, Volume 38, Issue 3, March 2025, Pages 151–160, https://doi.org/10.1093/ajh/hpae134
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Abstract
Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure and flow. This review focuses on the role of the transient receptor potential (TRP) superfamily of cation channels in this process. We discuss how specific members of the TRP superfamily (TRPC6, TRPM4, TRPV1, TRPV4, and TRPP1) regulate the resting membrane and intracellular Ca2+ levels in SMCs and ECs to promote changes in vascular tone in response to intraluminal pressure and shear stress. Although TRP channels participate in vascular mechanotransduction, little evidence supports their intrinsic mechanosensitivity. Therefore, we also examine the evidence exploring the force-sensitive signal transduction pathways acting upstream of vascular TRP channels. Understanding the interplay between mechanosensors, force-induced signaling cascades, and TRP channels holds promise for the development of targeted therapies for diseases caused by vascular dysfunction.
- hypertension
- electroconvulsive therapy
- signal transduction
- endothelial cells
- blood pressure
- cations
- ion channels
- tissue membrane
- tryptophan
- signal transduction pathways
- shear stress
- transmural
- epidural cortical stimulation
- transient receptor potential channels
- trpv1 receptor
- mechanotransduction, cellular
- molecular targeted therapy
- mechanical energy
- myocytes, smooth muscle
- fluid flow
- trpc6 cation channel
- trpm4 gene