... to special Petri net classes, e.g. hybrid Petri nets ( ) [ 23 ], fuzzy continuous Petri nets ( ) [ 24 ], or fuzzy stochastic Petri nets ( ) [ 4 ]. Figure 1 A Petri net diagram describing a part of cholesterol metabolism in an abstract form. VLDL is converted into LDL in the extracellular space, which...

... in patients with liver cancer. These data collectively demonstrated that ENO1 functions in protein cleavage by binding to BACE2 and promotes liver cancer progression by reprogramming cholesterol metabolism. ENO1 BACE2 LDLR protein cleavage liver cancer cholesterol metabolism O RIGIN A L U N EDITED M AN U...

... of cholesterol metabolism underlies neurodegenerative disease and is increasingly implicated in neuroinflammatory diseases, such as multiple sclerosis (MS). Cytochrome P450 family 7 subfamily B member 1 (CYP7B1) is a key enzyme in alternative cholesterol metabolism. A recessive mutation in the gene CYP7B1...

... About page for additional terms. 2024 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) glucocorticoid adrenal cholesterol metabolism ATP-binding...

... of rats and maintained the balance of cholesterol metabolism in the body by inhibiting the activity of liver X receptors (LXR) target genes, increasing the active expression of cholesterol 7 alpha-hydroxylase, and reducing the active expression of sterol-regulatory element-binding protein and 3-hydroxy-3...

... resembled protumor M2-like macrophage phenotypes. Gene expression panels of the infiltrating monocytes demonstrated that the upregulated genes were enriched in the cholesterol metabolism pathway. Cholesterol metabolism–related genes were upregulated together with the nuclear receptors, PPARG...

...Chenghao Zhang; Wanlin Dai; Shaojie Yang; Shuodong Wu; Jing Kong In the early stage, there were studies focused on the expression of hepatic cholesterol metabolism key molecules and GSD ( 16 ). These studies are summarized and analyzed in this section ( Table 1 ). In recent years, cholesterol...

... with lipid metabolism, particularly cholesterol metabolic abnormalities, are critically involved in the progression of atherosclerosis. The accumulation of lipids in the subendothelial spaces leads to foam cell formation, triggers a state of chronic inflammation and initiates the formation of atherosclerotic...

...Xin-Yu Ke; Miaowen Zou; Chenqi Xu T cells lipid metabolism fatty acid metabolism cholesterol metabolism tumor microenvironment cancer immunotherapies T cells are vital components of the adaptive immune response that can discriminate between ‘self’ and ‘non-self’ antigens and build a barrier...

... of cholesterol efflux. Collectively, these findings for the first time identified magnetite NPs as one key toxic component of PM-promoted foam cell formation, and provided new insight of abnormal cholesterol metabolism into the pathogenesis of PM-induced AS. PM magnetite nanoparticles macrophage foam cells...

... of proteins implicated in cholesterol metabolism. Low-dose GSK126 treatment together with statins revealed strong growth inhibition in combinatorial treatments, but not in single treatments, both in DMG cells in vitro, in DMG spheroid cultures, and in chick and mouse in vivo models...

... production PPAR pathway cholesterol metabolism Administration of di-ortho phthalate esters with straight chain lengths of 3–7 carbons during male rat sexual differentiation induces “Phthalate Syndrome” ( Foster, 2005 ; Gray and Foster, 2003 ), which is a unique phenotype seen in exposed male offspring...

... dysfunction and abnormal cholesterol metabolism. As the main cerebrovascular disorder, stroke contributes to the onset and development of vascular dementia, another cerebrovascular disease, which can aggravate cognitive decline. In the CNS, cholesterol is the essential lipid component of neuronal plasma...

... cholesterol cholesterol/metabolism absorption cholesterol/biosynthesis hydroxymethylglutaryl-CoA reductase inhibitors biological availability Low vitamin D status has been reported to be prevalent in the USA and worldwide ( 1 ), although the absolute criteria for establishing low vitamin D status...

... a critical role in modulating cholesterol efflux and mediating the dynamic control of membrane remodeling during sperm maturation and capacitation. cholesterol metabolism Ppp3r2 sperm deformity sperm motility sperm maturation National Natural Science Foundation of China 10.13039/501100001809...

... of cholesterol homeostasis. Objective The study explores the mechanism by which miRNAs mediate high fat–induced changes of cholesterol metabolism in yellow catfish. Methods Yellow catfish (weight: 3.79 ± 0.16 g, 3 mo old, mixed sex) were fed 2 diets containing lipids at 11.3% [control (CON)] or 15.4...

... was quantified in the cell lysate, and a BCA protein assay was then performed. Total protein concentration was used to normalize Dil fluorescence values. luteolysis 27-hydroxycholesterol CYP27A1 liver x receptor sterol regulatory element binding protein STAR cholesterol metabolism progesterone corpus...

... in turn increases G-CSF levels and activates granulopoiesis. ²⁹ Therefore, phagocytosis of neutrophils in peripheral tissues may provide negative feedback for their mobilization from the bone marrow to fine tune neutrophil homeostasis in blood. Figure 2 Cholesterol metabolism and control...

... mevalonate pathway. All the evidences indicate that 24-hydroxylase pathway only accounts for a portion of cholesterol metabolism. Cholesterol synthesis is decreased in hippocampus of aging brain, the 24S-hydroxycholesterol level is slightly decreased as well. This could explain why the absolute cholesterol...

..., a significant amount of research has been devoted to identifying polymorphisms which may impact steroidogenesis and fertility. This review discusses current understanding of the effects of genetic variations in cholesterol metabolic pathways on human fertility that bridge novel linkages between cholesterol...