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Objectives The aim was to investigate oleic acid and nigella oil modified niosomes as novel carriers for enhanced pioglitazone (PGZ) oral delivery. Methods PGZ was encapsulated into niosomes of cholesterol, tween 80, and span 60 before (F1) and after incorporation of nigella oil (F2) or oleic acid ...
Background and Objectives This study is the first to comprehensively investigate the phenolic profile, therapeutic potential, and acute toxicity of Putoria calabrica , a Mediterranean medicinal plant. It aims to evaluate its potential for innovative wound healing formulations by analyzing the ...
Objectives Despite significant advancements in innovative therapy, lung cancer continues to have an unexpectedly low 5-year survival rate. This necessitates the urgent development of novel and effective therapies. One such potential therapy is Honokiol (HNK, C 18 H 18 O 2 ), a biphenolic natural ...
Background Overcoming multidrug resistance (MDR), which is often caused by the overexpression of ATP binding cassette (ABC) transporters in cancer cells remains a major challenge for cancer treatment. Receptor tyrosine kinase inhibitors have demonstrated potential in reversing MDR. This study aimed ...
Calophyllum brasiliense is employed in folk medicine as an analgesic and to treat inflammation. This study aimed to evaluate the anti-inflammatory effect of C. brasiliense leaves’ methanol extract, fractions, and the isolated compound amentoflavone. In vitro fMLP-induced neutrophil chemotaxis and ...
Background As a strategy in the development of effective cancer therapeutics, synthetic lethality has been used in clinical practice. Poly adenosine diphosphate (ADP)-ribose polymerase inhibitors are the first approved drug utilized synthetic lethality and achieved promising therapeutic efficacy in ...
Objective This research studied two extracts from Treculia africana leaves for their potential against hyperglycaemia-related disorders. Methods The influence of the extracts on α-glucosidase activity and albumin glycation was investigated, and cell viability was estimated in HT-29 human colorectal ...
Objectives Tiaogan Jiejiu Tongluo formula (TJTF) is a traditional Chinese medicine formula for liver disease. The purpose of this study was to explore the protective effects and mechanisms of TJTF on nonalcoholic fatty liver disease (NAFLD) mice. Methods A NAFLD model of mice was established by a ...
Objectives The purpose of this study was to explore the mechanism of naringin in atherosclerotic mice from the perspective of network pharmacology and non-targeted metabolomics. Methods ApoE −/− mice were induced to establish an atherosclerotic model to explore the pharmacodynamics and potential ...
Objectives Copaiba essential oil (CEO) is obtained through the distillation of copaiba balsam and has been used in the traditional medicine to treat inflammatory conditions. However, the highly lipophilic nature of CEO restricts its pharmaceutical use. This study evaluated the effect of CEO, ...
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Impact Factor: 2.8
5 year Impact Factor: 3.8
CiteScore: 6.6
Time to first decision: 36 days
Editor-in-Chief: D Jones, Queen's University of Belfast, UK
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