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Journal Article
Utilizing multimodal physical therapy for women complaining of sexual pain: a clinical perspective
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Dee Hartmann
The Journal of Sexual Medicine, Volume 22, Issue 3, March 2025, Pages 376–379, https://doi.org/10.1093/jsxmed/qdae179
Published: 11 April 2025
... pain multimodal physical therapy arousal pleasure, chronic vulvar pain Female sexual pain, or dyspareunia, has any number of culpable etiologies. When considering chronic vulvar or superficial pain associated with vulvodynia, symptoms can be localized to pain only at the vulva, as in provoked...
Journal Article
A randomized trial on the safety and efficacy of sensate water-based and silicone-based personal lubricants for relief of intimate discomfort associated with vaginal dryness
Michael Krychman and others
The Journal of Sexual Medicine, qdaf058, https://doi.org/10.1093/jsxmed/qdaf058
Published: 07 April 2025
... of menopause sexual function sexual pleasure sexual arousal Reckitt Healthcare Ltd Vaginal dryness, or decreased vaginal lubrication, is generally associated with menopause; 1 however, it can occur at any age. 2 , 3 Over 15% of premenopausal women experience...
Journal Article
Menopause is associated with a decrease in sexual function among women with endometriosis
Alexandre Vallée and others
Sexual Medicine, Volume 13, Issue 2, April 2025, qfaf019, https://doi.org/10.1093/sexmed/qfaf019
Published: 05 April 2025
... was the FSFI total score and its six domains (desire, arousal, vaginal lubrication, orgasm, satisfaction, and dyspareunia) in menopausal and non-menopausal women with endometriosis. Results Menopausal women had significantly lower FSFI scores (15.3 vs. 16.9, P = 0.021). After adjustment, FSFI...
Journal Article
Exploring subjective and genital sexual response in transgender women upon addition of low-dose testosterone to feminizing gender-affirming hormone therapy: a feasibility study
Noor C Gieles and others
The Journal of Sexual Medicine, qdaf041, https://doi.org/10.1093/jsxmed/qdaf041
Published: 18 March 2025
...] compared to before testosterone supplementation. After testosterone supplementation, participants reported significantly stronger feelings of sexual arousal, genital sensations, and positive affect in response to erotic fantasy and erotic film. Finally, there was a significant improvement in sexual...
Journal Article
Application of International Society for the Study of Women’s Sexual Health consensus algorithm for persistent genital arousal disorder/genito-pelvic dysesthesia to 10 cases and use of epidural spinal injections as long term management
Hannah Ahrendt and others
Sexual Medicine, Volume 13, Issue 1, February 2025, qfaf008, https://doi.org/10.1093/sexmed/qfaf008
Published: 02 March 2025
... term solution for PGAD/GPD symptom relief. Persistent genital arousal disorder/genito-pelvic dysesthesia (PGAD/GPD) is a debilitating but poorly understood condition without formal diagnostic criteria. A recent International Society for the Study of Women’s Sexual Health (ISSWSH) consensus statement...
Journal Article
Bidirectional associations between daily subjective stress and sexual desire, arousal, and activity in healthy men and women
Hanna M Mües and others
Annals of Behavioral Medicine, Volume 59, Issue 1, January 2025, kaaf007, https://doi.org/10.1093/abm/kaaf007
Published: 26 February 2025
... the feasibility of an ecological momentary assessment study including time-based and event-based measurements in this context (aim 1) and investigated concurrent and time-lagged bidirectional associations between subjective stress and sexual desire/arousal/activity in the daily lives of healthy individuals over...
Journal Article
The assessment of the sexuality of patients with a borderline personality disorders based on their 2D:4D digit ratio
Justyna Holka-Pokorska and Adam Kucharski
Sexual Medicine, Volume 13, Issue 1, February 2025, qfaf006, https://doi.org/10.1093/sexmed/qfaf006
Published: 15 February 2025
.... Elements of sexual response were measured using the Arizona Sexual Experience Scale (ASEX). The digit ratio (2D:4D) served as a biomarker for testosterone and estrogen exposure during early prenatal development. Main outcomes ASEX results were analyzed in the categories of “desire,” “arousal...
Journal Article
Cross-sectional and prospective associations between self-compassion and sexual distress in couples coping with sexual interest/arousal disorder
Maude Massé-Pfister and others
The Journal of Sexual Medicine, Volume 22, Issue 3, March 2025, Pages 404–415, https://doi.org/10.1093/jsxmed/qdaf007
Published: 07 February 2025
...(4.6%) 8(3%) Questioning 5(1.9%) 3(1.1%) Not listed 3(1.1%) 0(0%) Note. M = mean; SD = standard deviation; SIAD = sexual interest/arousal disorder. a Includes Unemployed, Retired, Parental leave, Unable to work due to disability and Other b Includes Indigenous...
Journal Article
Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea
Xiaoting Wang and others
in
Sleep
Sleep, zsaf012, https://doi.org/10.1093/sleep/zsaf012
Published: 17 January 2025
... with obstructive sleep apnea (OSA), but predicting the response to surgery remains a challenge. The underlying endotypes of OSA include upper airway collapsibility, muscle compensation, loop gain, and the arousal threshold. This study aimed to explore the effect of surgery on polysomnography (PSG)-derived OSA...
Journal Article
Arousal effects on oscillatory dynamics in the non-human primate brain
Shashank A Anand and others
Cerebral Cortex, Volume 34, Issue 12, December 2024, bhae473, https://doi.org/10.1093/cercor/bhae473
Published: 20 December 2024
... cited. For commercial re-use, please contact [email protected] Abstract Arousal states are thought to influence many aspects of cognition and behavior by broadly modulating neural activity. Many studies have observed arousal-related modulations of alpha (~8 to 15 Hz) and gamma (~30 to 50 Hz...
Journal Article
Anatomic maps of erogenous and aversive sensation zones of the breasts, vulva, and vagina: a questionnaire-based study
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Jenna Stelmar and others
The Journal of Sexual Medicine, Volume 22, Issue 1, January 2025, Pages 7–13, https://doi.org/10.1093/jsxmed/qdae143
Published: 20 November 2024
..., while other ASZs were reportedly due to pain and sensitivity. sexual arousal vagina breasts vulva pleasure erogenous sensation maps Erogenous sensation zones (ESZs) are anatomic structures that elicit sexual arousal in response to stimulation. Conversely, aversive sensation zones (ASZs) are areas...
Journal Article
Impact of age, race, and medication use on efficacy endpoints in a randomized controlled trial of topical sildenafil cream for the treatment of female sexual arousal disorder
Isabella Johnson and others
Sexual Medicine, Volume 12, Issue 5, October 2024, qfae079, https://doi.org/10.1093/sexmed/qfae079
Published: 19 November 2024
... unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background A study of topical Sildenafil Cream 3.6% was completed among healthy premenopausal women with female sexual arousal disorder. Aims To compare efficacy endpoints based...
Journal Article
What should we be studying? Research priorities according to women and gender-diverse individuals with sexual interest/arousal disorder and their partners
Justin P K Shimizu and others
The Journal of Sexual Medicine, Volume 21, Issue 11, November 2024, Pages 1020–1029, https://doi.org/10.1093/jsxmed/qdae121
Published: 20 September 2024
.... A secondary aim was to compare the frequency of their stated priorities to effectively and accurately direct future research toward the topics deemed most important by those affected by SIAD. Abstract Background Sexual interest/arousal disorder (SIAD) is one of the most common sexual problems for women...
Journal Article
Eye tracking is more sensitive than skin conductance response in detecting mild environmental stimuli
Saman Khazaei and Rose T Faghih
in
PNAS Nexus
PNAS Nexus, Volume 3, Issue 9, September 2024, pgae370, https://doi.org/10.1093/pnasnexus/pgae370
Published: 28 August 2024
...Saman Khazaei; Rose T Faghih; Derek Abbott The underlying arousal-related ANS activation can be recovered from the “spikey” nature of the SC signal ( 8 ). The onset and amplitude of the recovered ANS activation can be utilized to form various types of observation vectors and decode the hidden...
Journal Article
Sex-specific age-related worsening of pathological endotypic traits in patients with obstructive sleep apnea
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Liang-Wen Hang and others
in
Sleep
Sleep, Volume 48, Issue 1, January 2025, zsae185, https://doi.org/10.1093/sleep/zsae185
Published: 11 August 2024
... and abdominal movements, resulting in a desaturation of ≥4% of oxygen saturation, following the definition of the American Academy of Sleep Medicine [ 14 ]. Four endotypic traits, namely arousal threshold, upper airway collapsibility, loop gain, and upper airway muscle compensation, were estimated using...
Journal Article
Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder
Andrea R Thurman and others
The Journal of Sexual Medicine, Volume 21, Issue 9, September 2024, Pages 793–799, https://doi.org/10.1093/jsxmed/qdae089
Published: 31 July 2024
... a predetermined placebo response on the 15-question Female Sexual Distress Scale–Desire, Arousal, Orgasm. 24 Eligible participants were randomized at visit 4 in a 1:1 manner to sildenafil cream vs placebo cream. The double-blind dosing period lasted 12 weeks, with monthly assessments at visits 5...
Journal Article
Comparisons and correlations of 1-month recall vs 24-hour recall in patient-reported outcomes of an exploratory, phase 2b, randomized, double-blind, placebo-controlled clinical trial of sildenafil cream, 3.6% for the treatment of female sexual arousal disorder
Isabella Johnson and others
The Journal of Sexual Medicine, Volume 21, Issue 9, September 2024, Pages 787–792, https://doi.org/10.1093/jsxmed/qdae086
Published: 26 July 2024
...Isabella Johnson; Andrea Ries Thurman; Katherine A Cornell; Tara Symonds; Jessica Hatheway; David R Friend; Andrew Goldstein Topical sildenafil cream, 3.6% (sildenafil cream) was developed for the treatment of female sexual arousal disorder (FSAD). Treatment efficacy in this phase 2b, randomized...
Journal Article
EDITOR'S CHOICE
Impaired cognition in narcolepsy: clinical and neurobiological perspectives
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Christopher A Cano and others
in
Sleep
Sleep, Volume 47, Issue 9, September 2024, zsae150, https://doi.org/10.1093/sleep/zsae150
Published: 29 June 2024
... to understand these deficits, and highlights some of the many key unanswered questions. narcolepsy orexin hypocretin cognition attention executive function memory arousal Statement of Significance Many people with narcolepsy are bothered by cognitive challenges such as difficulty sustaining attention...
Journal Article
Ecological momentary assessment of sleep, pain, and opioid use among adolescents following surgery
Andrew H Rogers and others
SLEEP Advances, Volume 5, Issue 1, 2024, zpae039, https://doi.org/10.1093/sleepadvances/zpae039
Published: 17 June 2024
... interventions targeting sleep quality and quantity to reduce pain and opioid use. pain depression pediatrics—sleep and arousal Statement of Significance Associations between sleep deficiency and opioid use remain poorly described in clinical populations. We evaluate pain intensity and mood symptoms...
Journal Article
Functionality of arousal-regulating brain circuitry at rest predicts human cognitive abilities
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Ella Podvalny and others
Cerebral Cortex, Volume 34, Issue 5, May 2024, bhae192, https://doi.org/10.1093/cercor/bhae192
Published: 14 May 2024
... ( Glasser et al. 2016 ) and used as predictors of arousal-linked inhibition of spontaneous brain activity as follows: (2) where indicates the subject average minimal cross-correlation between pupil size and brain activity, and indicates the receptor map of receptor density data. Only regions showing...
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