Volume 96, Issue 5, Nov 2014

A tribute to Nancy McCartney-Francis, highlighting her contributions in the field of leukocyte biology.

Discussion on the manipulation of myeloid suppressor cells as a novel therapeutic approach in organ transplantation.

Discussion of myeloid-derived suppressor cells expansion in patients with gram-positive sepsis.

MDSC glucocorticoids-GR-NO signaling is required for prolonging allograft survival.

The causative microorganism dictates the type of MDSC generated in sepsis patients; a large proportion of PMN-MDSCs in gram-positive sepsis are immunosuppressive myeloid blasts.

Review on how neutrophils modulate the behavior of oral squamous cell carcinoma, and the possible use of neutrophils as biomarkers of OSCC.

Review on the intricate structure, composition and function of lipid body organelles as modulators of immune responses in human eosinophils.

Review on the mechanisms of WIP activity, a key regulator of actin-based processes in leukocytes with a special focus on its WASp-independent functions.

Review of how macrophage polarization affects the rate of phagosome maturation.

Review on SAP affects neutrophil adhesion, monocyte differentiation, and macrophage polarization in the innate immune system.

Review on the influence of complement proteins, activation fragments, and regulatory receptors on T cell function, noting differences between humans and mice.

Review on interactions among cells of the innate immune system during chronic Hepatitis C virus infection, and their effects on the disease outcome.

Review of clinical and scientific evidence of different aspects of CD4 T cells affected by sepsis-induced immunosuppression.

Review on how autophagy in leukocytes leads to a new mechanism involving phospholipase D and the Wnt pathway, when deregulated, can have pathophysiological consequences.

Proinflammatory effects of SIRT1 inhibition exerts phase specific changes with decreased survival during hyper-inflammation, and increased survival during hypo-inflammation phases of sepsis.

Post-injury differentiation of dysfunctional CD1a⁺ monocytederived dendritic cells can result from elevated thrombospondin-1, triggering CD47, and increasing inhibitory SHP-1 activation and immunodepression.

PD-1 immunomodulates T_reg function in the resolution of indirect ALI, induced by shock/sepsis.

Antibodies to an adenovirus vaccine carrier affect magnitude and differentiation of the transgene product-specific CD8⁺ T cell responses.

Changes in bone marrow differentiation induced by Western diet include changes in DNA methylation, are transplantable, and augment atherosclerosis.

Concomitant clustering targets invariant chain-MHC II to the B cell receptor, and reveals a novel function for the invariant chain ligand MIF.

A dynamic estrogen receptor network by which E2 can mediate fine regulation of lymphocyte function.

Lipid rafts regulate SR-A-mediated macrophage adhesion via regulating PLA2 activation.

Gr-1+CD11b+ myeloid cells drive CD80 downregulation on hepatic B cells, in the context of liver metastases.

TLR4 regulates inflammatory cytokine production from thymic- and peripherally-derived T_reg cells during intestinal inflammation.

Mouse alveolar macrophage PDE2A significantly inhibits the increased iNOS expression resulting from LPS exposure.

Failed host defense against intracellular Leishmania in absence of SLPI involves imbalance of Th1/Th2 cytokines and M1/M2 polarization linked to dysregulation of SOCS1 and IL-27.

LL-37 upregulates neutrophil respiratory burst and extracellular trap formation in response to influenza A virus, but reduces cytokine generation triggered by the virus.