Volume 96, Issue 4, October 2014
Issue Information
Issue Information
Editorials
Editorial: Gigantism: a new way to prolong neutrophil life
Discussion on the existence of long-lived giant neutrophils that grow in size by internalizing cell debris from dying neutrophils.
Editorial: Does immune dysfunction persist into adulthood after adolescent use of marijuana?
Discussion on Δ9-tetrahydrocannabinol-induced immune dysfunction, from an anti-inflammatory response in adolescence to a proinflammatory switch in adulthood using a murine model.
Spotlight on Leading Edge Research
The development of giant phagocytes in long-term neutrophil cultures
Spontaneous development of long-lived giant phagocytes in prolonged neutrophil cultures in vitro is mediated by autophagy and characterized by phagocytosis, oxLDL uptake, and ROS production.
Δ9-Tetrahydrocannabinol-induced anti-inflammatory responses in adolescent mice switch to proinflammatory in adulthood
Δ9-Tetrahydrocannabinol exposure in adolescent mice induces anti-inflammatory responses; modulation persists into adulthood with immunity switched toward a proinflammatory phenotype.
Reviews
Immune control and failure in HCV infection—tipping the balance
Review on the innate and adaptive immune responses to Hepatitis C virus.
Cell Development, Differentiation, & Trafficking
G-CSF preferentially supports the generation of gut-homing Gr-1high macrophages in M-CSF-treated bone marrow cells
G-CSF promotes generation of ‘M2-like’ gut homing macrophages from M-CSF-treated bone marrow cells.
Receptors, Signal Transduction, & Genes
Folate receptor-β constitutes a marker for human proinflammatory monocytes
Folate receptor-β mediated targeting of inflammatory monocytes in inflammation.
Hepatocytes induce Foxp3+ regulatory T cells by Notch signaling
Mechanism by which hepatocytes induce functional regulatory T cells.
The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin
Induction of type I and III IFNs depends on mTOR, and acts in collaboration with TBK1 in human conventional DCs.
An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
Interferon-β mediates the activation of ISGF3 and induction of interferon-stimulated genes, by lipopolysaccharide in macrophages.
Renin modulates HIV replication in T cells
Renin contributes to HIV replication in T cells via (P) RRPLZF signaling cascade and cleavage of Gag polyproteins.
Inflammation, Extracellular Mediators, & Effector Molecules
Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes
S1P induces expression of the protease-activated receptor-4 (PAR-4) in human monocytes, and enhances chemotaxis and COX-2 formation in response to thrombin.
HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells
HPV16 associated tumors induce cell proliferation, modulate cell signaling, and cytokine expression in antigen presenting cells, favoring regulatory T cell expansion in peripheral lymphoid organs.
The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8+ T cells
The TGF-β-inducible miR-23a cluster attenuates IFN-γ production and antigen specific cytotoxicity, and fine-tunes CD8+ T cell effector functions.
Translational & Clinical Immunology
γ/δ T cell subsets in human aging using the classical α/β T cell model
γ/δ T cells have a differential susceptibility to immunosenescence compared to α/β T cells, during human aging.
Systems Biology & Immunogenetics
Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice
Chronic alcohol ingestion leads to the recruitment of infiltrating macrophages into the liver, which show distinguished phenotypes and functions from liver- resident Kupffer cells.
