Volume 96, Issue 6, Dec 2014

Discussion on potential new therapies for respiratory syncytial virus.

Discussion of how HMBPP-deficient Listeria mutant in macaques elicits lower pulmonary trafficking of Vγ9Vδ2 T cells, as compared to the HMBPP-producing strain.

Therapeutic manipulation of macrophage differentiation to enhance the AAM phenotype may be a viable approach for ameliorating RSV-induced disease.

Role for microbial production of phosphoantigen in infection-driven responses of primate γδ T cells in vivo.

Review of key features of differentiation and function of mononuclear phagocytes, which comprise the non-resident monocyte/macrophage populations in the body.

Review on the phenotype and function of tissue-specific NK cells suggesting some subpopulations differentiate in situ from tissue-resident hematopoietic stem cells.

Review of how pattern-recognition receptor NLRP12 are modulators of the inflammatory network during infection, cancer, and autoinflammatory disorders.

The absence of langerin/CD207 and CX₃CR1 on splenic CD8α-positive DC identifies a functionally immature CD8α⁺ DC precursor, independent of Batf3 expression.

Survival of macrophages is distinctly regulated during and after differentiation.

miR-199a-5p inhibits monocyte/macrophage differentiation via down-regulating ACVR1B, further reducing phosphorylation of Smad2/3, resulting in decreased expression of C/EBPα.

A novel IL-18Rα isoform and activation-induced splicing of IL-18Rα down-modulates IFNα production in human pDCs upon viral exposure.

Granulocyte viability, phagocytosis, IL-8 secretion, chemotaxis, and antifungal activity are completely preserved in the absence of extracellular arginine.

IP-10 can inhibit T cell responses in HIV-1 infected subjects on ART.

A role for Pdcd4 in macrophage alternative activation and airway remodeling.

Formation of glyceraldehyde-derived advanced glycation endoproducts contributes to the pathogenesis of endogenous uvetitis in human and animals.

Isoliquiritigenin, a component of Glycyrrhiza uralensis, is a potent inhibitor of the NLRP3 inflammasome, and suppresses diet-induced obesity, adipose tissue inflammation, and metabolic disorders.

The expression of INF-ɛ in multiple mucosal tissues of rhesus macaques.

Interactions between MDSC, macrophages, and tumor cells alter the cytokine milieu, impacting inflammation in the tumor microenvironment.

NK cells directly kill mycobacteria through a contactdependent mechanism leading to the release of perforin and granulysin.

Assessment of different ADRB assays to determine their suitability for the evaluation of neutrophil stimulation by antimalarial antibodies.

Xenopus laevis CSF1 renders tadpoles and tadpole macrophages susceptible to the FV3 ranavirus, whereas IL34 increases tadpole and tadpole macrophage resistance.

Expansion of Th22 cells in multiple sclerosis could critically influence the resistance to IFN-β therapy.

In vitro human T cell development from hematopoietic stem cells in the presence and absence of feeder cells is promoted by ascorbic acid.