Volume 50, Issue 7, July 2020
Review
Preservation of fertility in patients with hematological malignancies
Treatment for hematological malignancies carries gonadal toxicity, so that the preservation of fertility should be considered in all patients in childhood, adolescence and young adulthood.
Accelerated partial breast irradiation by brachytherapy: present evidence and future developments
Adjuvant treatment of endometrial cancer today
This review describes the present treatment options for endometrial cancer according to the risk of recurrence and the current evidence along with a history of the pertinent clinical trials.
Original Articles
Epidemiology/Public Health
Impact of gender and employment type on job loss among cancer survivors
This study highlighted that women and temporary employees were more vulnerable with job loss after cancer diagnosis.
Orthopedics/Sarcoma
Functional evaluation following deltoid muscle resection in patients with soft tissue sarcoma
The functional outcome following deltoid muscle resection in patients with soft tissue sarcoma was evaluated. If the rotator cuff is resected with deltoid muscle, satisfactory functional outcomes might not be obtained.
Palliative and Supportive Care
Experiences and hidden needs of older patients, their families and their physicians in palliative chemotherapy decision-making: a qualitative study
The present study explored MUC5AC in lung adenocarcinoma with mucin production. MUC5AC and its impact of prognosis in different mucinous subtypes are distinct. These findings strongly demonstrate the heterogeneity of lung adenocarcinoma with mucin production.
Validation study of the Japanese version of MD Anderson Symptom Inventory for Brain Tumor module
The newly developed Japanese version of MDASI-BT, validated linguistically and psychometrically, is a feasible and reliable patient-reported outcome questionnaire for the assessment of symptom severity and interference in brain tumor patients.
Thoracic Surgery
Combined sleeve lobectomy for centrally located primary lung cancer and lung cancer with hilar lymph node metastasis
Bronchial sleeve lobectomy with additional methods is feasible for lung cancer treatment.
Tumor Markers
Association between PD-L1 status and immune checkpoint inhibitor response in advanced malignancies: a systematic review and meta-analysis of overall survival data
This stratified meta-analysis demonstrates that PD-L1 levels have important predictive value in determining response to immunotherapy. However, patients with low levels still experience improved survival with immunotherapy compared with standard therapy.
Urology
Efficacy and safety of abiraterone acetate plus prednisone in Japanese patients with newly diagnosed, metastatic hormone-naive prostate cancer: final subgroup analysis of LATITUDE, a randomized, double-blind, placebo-controlled, phase 3 study
In this Japanese subpopulation analysis of LATITUDE, addition of abiraterone acetate plus prednisone to androgen-deprivation therapy demonstrated favorable long-term efficacy and safety in patients with high-risk metastatic hormone-naïve prostate cancer.
Clinical Trial Note
A randomized phase III study comparing continuation and discontinuation of PD-1 pathway inhibitors for patients with advanced non-small-cell lung cancer (JCOG1701, SAVE study)
This phase III trial aims to confirm the non-inferiority of discontinuation versus continuation of treatment with immune checkpoint inhibitors, including PD-1 pathway inhibitors, for advanced/recurrent non-small-cell lung patients.
Cancer Genetics Report
A novel germline BMPR1A variant (c.72_73delGA) in a Japanese family with hereditary mixed polyposis syndrome
We report a novel germline BMPR1A variant, c.72_73delGA, in a Japanese family with HMPS-2.
Short Communication
Palliative care physicians’ perspectives of management for terminally ill cancer patients with death rattle: a nationwide survey
We investigated the perceptions of Japanese palliative care physicians for death rattle. One-third administer anticholinergic agents despite a lack of established evidence.