Volume 197, Issue 9
November 2016
Cover image
Cover image
On the cover: Gill preparation dissected from an adult zebrafish carrying the cd4-1:mCherry reporter transgene. CD4+ cells (red fluorescence) can be seen resident in the epithelium of the branchial filaments and lamellae epithelium. Dee, C. T., R. T. Nagaraju, E. I. Athanasiadis, C. Gray, L. Fernandez del Ama, S. A. Johnston, C. J. Secombes, A. Cvejic, and A. F. L. Hurlstone. 2016. CD4-transgenic zebrafish reveal tissue-resident Th2- and regulatory T cell–like populations and diverse mononuclear phagocytes. J. Immunol. 197: 3520–3530.
ISSN 0022-1767
EISSN 1550-6606
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Volume 197, Issue 9, November 2016
In This Issue
In This Issue
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3427–3428, https://doi.org/10.4049/jimmunol.1690017
Pillars of Immunology
OKT3 and H57-597: From Discovery, to Commercialization, to the Clinic
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3429–3430, https://doi.org/10.4049/jimmunol.1601599
Pillars Article: OKT3: A Monoclonal Anti-Human T Lymphocyte Antibody with Potent Mitogenic Properties. J. Immunol. 1980. 124: 2708–2713
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3431–3436, https://doi.org/10.1093/jimmunol/197.9.3431
Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736–2742
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3437–3443, https://doi.org/10.1093/jimmunol/197.9.3437
Allergy and Other Hypersensitivities
IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3445–3453, https://doi.org/10.4049/jimmunol.1600611
Antigen Recognition and Responses
TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3454–3463, https://doi.org/10.4049/jimmunol.1501925
Autoimmunity
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3464–3470, https://doi.org/10.4049/jimmunol.1502641
CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3471–3480, https://doi.org/10.4049/jimmunol.1600135
Clinical and Human Immunology
Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3481–3489, https://doi.org/10.4049/jimmunol.1600388
Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3490–3503, https://doi.org/10.4049/jimmunol.1601054
Immune Regulation
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3504–3511, https://doi.org/10.4049/jimmunol.1501600
Antigen-Specific Development of Mucosal Foxp3+RORγt+ T Cells from Regulatory T Cell Precursors
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3512–3519, https://doi.org/10.4049/jimmunol.1601217
CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3520–3530, https://doi.org/10.4049/jimmunol.1600959
Chemotaxis and Immunoregulatory Function of Cardiac γδ T Cells in Dystrophin-Deficient Mice
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3531–3544, https://doi.org/10.4049/jimmunol.1600335
Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor–Mediated mTOR Inhibition in Human Keratinocytes
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3545–3553, https://doi.org/10.4049/jimmunol.1500546
Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor–Mediated T Cell Tolerance
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3554–3565, https://doi.org/10.4049/jimmunol.1601032
Immunogenetics
A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3566–3574, https://doi.org/10.4049/jimmunol.1502263
Immunotherapy and Vaccines
Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3575–3585, https://doi.org/10.4049/jimmunol.1600893
High Doses of GM-CSF Inhibit Antibody Responses in Rectal Secretions and Diminish Modified Vaccinia Ankara/Simian Immunodeficiency Virus Vaccine Protection in TRIM5α-Restrictive Macaques
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3586–3596, https://doi.org/10.4049/jimmunol.1600629
A Tetravalent Formulation Based on Recombinant Nucleocapsid-like Particles from Dengue Viruses Induces a Functional Immune Response in Mice and Monkeys
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3597–3606, https://doi.org/10.4049/jimmunol.1600927
IL-10–Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3607–3617, https://doi.org/10.4049/jimmunol.1501769
Infectious Disease and Host Response
Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3618–3627, https://doi.org/10.4049/jimmunol.1600385
Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3628–3638, https://doi.org/10.4049/jimmunol.1600734
Innate Immunity and Inflammation
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3639–3649, https://doi.org/10.4049/jimmunol.1600402
Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3650–3661, https://doi.org/10.4049/jimmunol.1600820
MK2/3 Are Pivotal for IL-33–Induced and Mast Cell–Dependent Leukocyte Recruitment and the Resulting Skin Inflammation
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3662–3668, https://doi.org/10.4049/jimmunol.1600658
Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3669–3679, https://doi.org/10.4049/jimmunol.1501876
Mannan-Binding Lectin–Associated Serine Protease 1/3 Cleavage of Pro–Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference–Mediated Gene Silencing
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3680–3694, https://doi.org/10.4049/jimmunol.1600719
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3695–3704, https://doi.org/10.4049/jimmunol.1600845
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3705–3715, https://doi.org/10.4049/jimmunol.1600909
Mucosal Immunology
Humoral Immunity Provides Resident Intestinal Eosinophils Access to Luminal Antigen via Eosinophil-Expressed Low-Affinity Fcγ Receptors
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3716–3724, https://doi.org/10.4049/jimmunol.1600412
Transplantation
G-CSF–Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3725–3734, https://doi.org/10.4049/jimmunol.1502023
Tumor Immunology
Accumulation of CD11c+CD163+ Adipose Tissue Macrophages through Upregulation of Intracellular 11β-HSD1 in Human Obesity
The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3735–3745, https://doi.org/10.4049/jimmunol.1600895
