-
Views
-
Cite
Cite
Kaibin Shi, Zhen Wang, Yuanchu Liu, Ye Gong, Ying Fu, Shaowu Li, Kristofer Wood, Junwei Hao, Guang-Xian Zhang, Fu-Dong Shi, Yaping Yan, CFHR1-Modified Neural Stem Cells Ameliorated Brain Injury in a Mouse Model of Neuromyelitis Optica Spectrum Disorders, The Journal of Immunology, Volume 197, Issue 9, November 2016, Pages 3471–3480, https://doi.org/10.4049/jimmunol.1600135
- Share Icon Share
Abstract
A major hurdle for effective stem cell therapy is ongoing inflammation in the target organ. Reconditioning the lesion microenvironment may be an effective way to promote stem cell therapy. In this study, we showed that engineered neural stem cells (NSCs) with complement factor H–related protein 1, a complement inhibitor protein, can attenuate inflammatory infiltration and immune-mediated damage of astrocytes, an important pathogenic progress in patients with neuromyelitis optica spectrum disorders. Furthermore, we demonstrated that transplantation of the complement factor H–related protein 1–modified NSCs effectively blocked the complement activation cascade and inhibited formation of the membrane attack complex, thus contributing to the protection of endogenous and transplanted NSC-differentiated astrocytes. Therefore, manipulation of the lesion microenvironment contributes to a more effective cell replacement therapeutic strategy for autoimmune diseases of the CNS.