Volume 186, Issue 8
April 2011
Cover image
Cover image
On the cover: Twenty-five TLR4 TIR dimer models in which the BB loop of one TIR domain interacts with the E helix of the other. Toshchakov et al. screened a library of TLR4 TIR-derived decoy peptides to demonstrate that peptides derived from these regions inhibit TLR4 signaling by binding to the TLR4 TIR. Toshchakov, V. Y., H. Szmacinski, L. A. Couture, J. R. Lakowicz, and S. N. Vogel. 2011. Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: Identification of the TLR4 Toll/IL-1 receptor domain dimerization interface. J. Immunol. 186: 4819-4827.
ISSN 0022-1767
EISSN 1550-6606
Issue navigation
Volume 186, Issue 8, April 2011
In this Issue
In This Issue
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4531–4532, https://doi.org/10.4049/jimmunol.1190009
Letters to the Editor
Comment on “Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development”
The Journal of Immunology, Volume 186, Issue 8, April 2011, Page 4533, https://doi.org/10.4049/jimmunol.1190011
Brief Reviews
Physiologic Control of the Functional Status of Foxp3+ Regulatory T Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4535–4540, https://doi.org/10.4049/jimmunol.1002937
Cutting Edge
Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4541–4545, https://doi.org/10.4049/jimmunol.1003389
Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17+ γδ T Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4546–4550, https://doi.org/10.4049/jimmunol.1004021
Cutting Edge: De Novo Induction of Functional Foxp3+ Regulatory CD4 T Cells in Response to Tissue-Restricted Self Antigen
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4551–4555, https://doi.org/10.4049/jimmunol.1003573
Cellular Immunology and Immune Regulation
Functional Plasticity of Antigen-Specific Regulatory T Cells in Context of Tumor
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4557–4564, https://doi.org/10.4049/jimmunol.1003797
Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4565–4572, https://doi.org/10.4049/jimmunol.1002529
Requirements for Eomesodermin and Promyelocytic Leukemia Zinc Finger in the Development of Innate-Like CD8+ T Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4573–4578, https://doi.org/10.4049/jimmunol.1100037
Gads Regulates the Expansion Phase of CD8+ T Cell-Mediated Immunity
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4579–4589, https://doi.org/10.4049/jimmunol.1001604
Human NK Cells Proliferate and Die In Vivo More Rapidly than T Cells in Healthy Young and Elderly Adults
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4590–4598, https://doi.org/10.4049/jimmunol.1002732
Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4599–4608, https://doi.org/10.4049/jimmunol.1001972
High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF-κB–Dependent Manner
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4609–4617, https://doi.org/10.4049/jimmunol.1002361
Memory CCR6+CD4+ T Cells Are Preferential Targets for Productive HIV Type 1 Infection Regardless of Their Expression of Integrin β7
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4618–4630, https://doi.org/10.4049/jimmunol.1004151
Impaired Basophil Induction Leads to an Age-Dependent Innate Defect in Type 2 Immunity during Helminth Infection in Mice
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4631–4639, https://doi.org/10.4049/jimmunol.1002995
Anergic Responses Characterize a Large Fraction of Human Autoreactive Naive B Cells Expressing Low Levels of Surface IgM
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4640–4648, https://doi.org/10.4049/jimmunol.1001946
NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4649–4655, https://doi.org/10.4049/jimmunol.1003888
Liver X Receptors Inhibit Macrophage Proliferation through Downregulation of Cyclins D1 and B1 and Cyclin-Dependent Kinases 2 and 4
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4656–4667, https://doi.org/10.4049/jimmunol.1000585
Differential Requirements for Th1 and Th17 Responses to a Systemic Self-Antigen
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4668–4673, https://doi.org/10.4049/jimmunol.1003786
The Neonatal FcR-Mediated Presentation of Immune-Complexed Antigen Is Associated with Endosomal and Phagosomal pH and Antigen Stability in Macrophages and Dendritic Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4674–4686, https://doi.org/10.4049/jimmunol.1003584
α-Galactosylceramide–Induced Airway Eosinophilia Is Mediated through the Activation of NKT Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4687–4692, https://doi.org/10.4049/jimmunol.1003659
IFN-α Mediates the Development of Autoimmunity both by Direct Tissue Toxicity and through Immune Cell Recruitment Mechanisms
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4693–4706, https://doi.org/10.4049/jimmunol.1002631
The TLR7 Ligand 9-Benzyl-2-Butoxy-8-Hydroxy Adenine Inhibits IL-17 Response by Eliciting IL-10 and IL-10–Inducing Cytokines
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4707–4715, https://doi.org/10.4049/jimmunol.1002398
Both miR-17-5p and miR-20a Alleviate Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating STAT3 Expression
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4716–4724, https://doi.org/10.4049/jimmunol.1002989
Filarial Infection Suppresses Malaria-Specific Multifunctional Th1 and Th17 Responses in Malaria and Filarial Coinfections
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4725–4733, https://doi.org/10.4049/jimmunol.1003778
Impairment of Regulatory Capacity of CD4+CD25+ Regulatory T Cells Mediated by Dendritic Cell Polarization and Hyperthyroidism in Graves’ Disease
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4734–4743, https://doi.org/10.4049/jimmunol.0904135
Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4744–4750, https://doi.org/10.4049/jimmunol.1003254
Molecular and Structural Immunology
Suppressor of Cytokine Signaling 1 Regulates Embryonic Myelopoiesis Independently of Its Effects on T Cell Development
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4751–4761, https://doi.org/10.4049/jimmunol.1000343
Dual Oxidase 1 Induced by Th2 Cytokines Promotes STAT6 Phosphorylation via Oxidative Inactivation of Protein Tyrosine Phosphatase 1B in Human Epidermal Keratinocytes
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4762–4770, https://doi.org/10.4049/jimmunol.1000791
Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted γδ T Cells in the Normal Murine Repertoire
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4771–4781, https://doi.org/10.4049/jimmunol.1000921
Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4782–4793, https://doi.org/10.4049/jimmunol.1001179
Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4794–4804, https://doi.org/10.4049/jimmunol.1000702
Hematopoietic Lineage Cell-Specific Protein 1 Functions in Concert with the Wiskott–Aldrich Syndrome Protein To Promote Podosome Array Organization and Chemotaxis in Dendritic Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4805–4818, https://doi.org/10.4049/jimmunol.1003102
Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4819–4827, https://doi.org/10.4049/jimmunol.1002424
A Serine Proteinase Homologue, SPH-3, Plays a Central Role in Insect Immunity
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4828–4834, https://doi.org/10.4049/jimmunol.1003246
Immunogenetics
CD5 Promotes IL-10 Production in Chronic Lymphocytic Leukemia B Cells through STAT3 and NFAT2 Activation
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4835–4844, https://doi.org/10.4049/jimmunol.1003050
Host Defense
CCL17 Controls Mast Cells for the Defense against Filarial Larval Entry
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4845–4852, https://doi.org/10.4049/jimmunol.1000612
Rapid and Transient Activation of γδ T Cells to IFN-γ Production, NK Cell-Like Killing, and Antigen Processing during Acute Virus Infection
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4853–4861, https://doi.org/10.4049/jimmunol.1003599
IL-2 Contributes to Maintaining a Balance between CD4+Foxp3+ Regulatory T Cells and Effector CD4+ T Cells Required for Immune Control of Blood-Stage Malaria Infection
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4862–4871, https://doi.org/10.4049/jimmunol.1003777
Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4872–4880, https://doi.org/10.4049/jimmunol.1003761
Novel Blocking Human IgG Directed against the Pentapeptide Repeat Motifs of Neisseria meningitidis Lip/H.8 and Laz Lipoproteins
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4881–4894, https://doi.org/10.4049/jimmunol.1003623
Decreased Leukocyte Accumulation and Delayed Bordetella pertussis Clearance in IL-6−/− Mice
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4895–4904, https://doi.org/10.4049/jimmunol.1000594
Inflammation
Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A4 Receptor and Operative in the Inflamed Microvasculature
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4905–4914, https://doi.org/10.4049/jimmunol.1003145
Macrophage Migration Inhibitory Factor and CD74 Regulate Macrophage Chemotactic Responses via MAPK and Rho GTPase
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4915–4924, https://doi.org/10.4049/jimmunol.1003713
Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4925–4935, https://doi.org/10.4049/jimmunol.1002739
Evidence That the Lipid Phosphatase SHIP-1 Regulates T Lymphocyte Morphology and Motility
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4936–4945, https://doi.org/10.4049/jimmunol.1002350
Phospholipase C-β3 Is a Key Modulator of IL-8 Expression in Cystic Fibrosis Bronchial Epithelial Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4946–4958, https://doi.org/10.4049/jimmunol.1003535
Periostin Regulates Goblet Cell Metaplasia in a Model of Allergic Airway Inflammation
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4959–4966, https://doi.org/10.4049/jimmunol.1002359
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4967–4972, https://doi.org/10.4049/jimmunol.1003021
Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4973–4983, https://doi.org/10.4049/jimmunol.1003600
Clinical Immunology
B Cell and BAFF Dependence of IFN-α–Exaggerated Disease in Systemic Lupus Erythematosus-Prone NZM 2328 Mice
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4984–4993, https://doi.org/10.4049/jimmunol.1000466
A Unique Hybrid Renal Mononuclear Phagocyte Activation Phenotype in Murine Systemic Lupus Erythematosus Nephritis
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 4994–5003, https://doi.org/10.4049/jimmunol.1003010
Apolipoprotein B Binding Domains: Evidence That They Are Cell-Penetrating Peptides That Efficiently Deliver Antigenic Peptide for Cross-Presentation of Cytotoxic T Cells
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 5004–5011, https://doi.org/10.4049/jimmunol.1003557
Corrections
Correction: IL-2–Controlled Expression of Multiple T Cell Trafficking Genes and Th2 Cytokines in the Regulatory T Cell-Deficient Scurfy Mice: Implication to Multiorgan Inflammation and Control of Skin and Lung Inflammation
The Journal of Immunology, Volume 186, Issue 8, April 2011, Pages 5012–5013, https://doi.org/10.4049/jimmunol.1190010
