Volume 186, Issue 7
April 2011
Cover image
Cover image
On the cover: The presence of a novel airway Ag sampling site, the respiratory M cell, was demonstrated in the turbinates covered with single-layer epithelium of murine nasal passages. SEM of the respiratory M cell revealed the classical characteristic features of M cells: a depressed surface with short and irregular microvilli. Kim, D.-Y., A. Sato, S. Fukuyama, H. Sagara, T. Nagatake, I. G. Kong, K. Goda, T. Nochi, J. Kunisawa, S. Sato, Y. Yokota, C. H. Lee, and H. Kiyono. 2011. The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens. J. Immunol. 186: 4253-4262.
ISSN 0022-1767
EISSN 1550-6606
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Volume 186, Issue 7, April 2011
In This Issue
In This Issue
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3801–3802, https://doi.org/10.4049/jimmunol.1190007
Letters to the Editor
Comment on “Epigenetic Reduction in Invariant NKT Cells following In Utero Vitamin D Deficiency in Mice”
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3803–3804, https://doi.org/10.4049/jimmunol.1190005
Pillars of Immunology
The Resurrection of T Cell-Mediated Suppression
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3805–3807, https://doi.org/10.4049/jimmunol.1100364
Pillars Article: Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor α-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases. J. Immunol. 1995. 155: 1151–1164
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3808–3821, https://doi.org/10.1093/jimmunol/186.7.3808
Brief Reviews
Protective B Cell Responses to Flu—No Fluke!
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3823–3829, https://doi.org/10.4049/jimmunol.1002090
Cutting Edge
Cutting Edge: Vasostatin-1–Derived Peptide ChgA29–42 Is an Antigenic Epitope of Diabetogenic BDC2.5 T Cells in Nonobese Diabetic Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3831–3835, https://doi.org/10.4049/jimmunol.1003617
Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3836–3840, https://doi.org/10.4049/jimmunol.1003949
Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3841–3845, https://doi.org/10.4049/jimmunol.1004058
Cellular Immunology and Immune Regulation
Nondominant CD8 T Cells Are Active Players in the Vaccine-Induced Antitumor Immune Response
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3847–3857, https://doi.org/10.4049/jimmunol.1000361
MyD88-Dependent SHIP1 Regulates Proinflammatory Signaling Pathways in Dendritic Cells after Monophosphoryl Lipid A Stimulation of TLR4
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3858–3865, https://doi.org/10.4049/jimmunol.1001034
Beraprost Enhances the APC Function of B Cells by Upregulating CD86 Expression Levels
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3866–3873, https://doi.org/10.4049/jimmunol.1002170
Differential B7–CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-Specific Memory CD8 T Cell Populations
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3874–3881, https://doi.org/10.4049/jimmunol.1003231
Repeated In Vivo Stimulation of T and B Cell Responses in Old Mice Generates Protective Immunity against Lethal West Nile Virus Encephalitis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3882–3891, https://doi.org/10.4049/jimmunol.1002799
Regulation of GATA-3 Expression during CD4 Lineage Differentiation
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3892–3898, https://doi.org/10.4049/jimmunol.1003505
Interplay between TNF and Regulatory T Cells in a TNF-Driven Murine Model of Arthritis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3899–3910, https://doi.org/10.4049/jimmunol.1003372
Ly49-Dependent NK Cell Licensing and Effector Inhibition Involve the Same Interaction Site on MHC Ligands
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3911–3917, https://doi.org/10.4049/jimmunol.1004168
Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3918–3926, https://doi.org/10.4049/jimmunol.1003099
Defining the Herpes Simplex Virus-Specific CD8+ T Cell Repertoire in C57BL/6 Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3927–3933, https://doi.org/10.4049/jimmunol.1003735
The Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1 Is an Intrinsic Central Regulator of Dendritic Cell Function
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3934–3945, https://doi.org/10.4049/jimmunol.1001675
T Cell Factor-1 Negatively Regulates Expression of IL-17 Family of Cytokines and Protects Mice from Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3946–3952, https://doi.org/10.4049/jimmunol.1003497
Role of SLAM in NKT Cell Development Revealed by Transgenic Complementation in NOD Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3953–3965, https://doi.org/10.4049/jimmunol.1003305
Identification of a New Phenotype of Tolerogenic Human Dendritic Cells Induced by Fungal Proteases from Aspergillus oryzae
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3966–3976, https://doi.org/10.4049/jimmunol.1003184
IL-27 and IL-21 Are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3977–3985, https://doi.org/10.4049/jimmunol.1003588
Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3986–3996, https://doi.org/10.4049/jimmunol.1001101
Vaccination against Lymphocytic Choriomeningitis Virus Infection in MHC Class II-Deficient Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 3997–4007, https://doi.org/10.4049/jimmunol.1001251
Simian Immunodeficiency Virus Infection in the Brain and Lung Leads to Differential Type I IFN Signaling during Acute Infection
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4008–4018, https://doi.org/10.4049/jimmunol.1003757
β1 Integrin Is Critical for the Maintenance of Antigen-Specific CD4 T Cells in the Bone Marrow but Not Long-Term Immunological Memory
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4019–4026, https://doi.org/10.4049/jimmunol.1003566
Genome-Wide Expression Profiling Identifies an Impairment of Negative Feedback Signals in the Crohn’s Disease-Associated NOD2 Variant L1007fsinsC
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4027–4038, https://doi.org/10.4049/jimmunol.1000085
Migration and Homeostasis of Naive T Cells Depends on Coronin 1-Mediated Prosurvival Signals and Not on Coronin 1-Dependent Filamentous Actin Modulation
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4039–4050, https://doi.org/10.4049/jimmunol.1003352
KLRG1+NKG2A+ CD8 T Cells Mediate Protection and Participate in Memory Responses during γ-Herpesvirus Infection
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4051–4058, https://doi.org/10.4049/jimmunol.1003122
Bid and Bim Collaborate during Induction of T Cell Death in Persistent Infection
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4059–4066, https://doi.org/10.4049/jimmunol.1001918
A Novel Tumor-Associated Pancreatic Glycoprotein Is Internalized by Human Dendritic Cells and Induces Their Maturation
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4067–4077, https://doi.org/10.4049/jimmunol.1000408
Targeting of a T Cell Agonist Peptide to Lysosomes by DNA Vaccination Induces Tolerance in the Nonobese Diabetic Mouse
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4078–4087, https://doi.org/10.4049/jimmunol.0902395
Conformational Switching in Ezrin Regulates Morphological and Cytoskeletal Changes Required for B Cell Chemotaxis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4088–4097, https://doi.org/10.4049/jimmunol.1001139
Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4098–4109, https://doi.org/10.4049/jimmunol.1002620
Protection from RNA and DNA Viruses by IL-32
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4110–4118, https://doi.org/10.4049/jimmunol.1000081
HIV-1 Tat-Mediated Induction of Platelet-Derived Growth Factor in Astrocytes: Role of Early Growth Response Gene 1
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4119–4129, https://doi.org/10.4049/jimmunol.1002235
A New Zealand Black-Derived Locus Suppresses Chronic Graft-versus-Host Disease and Autoantibody Production through Nonlymphoid Bone Marrow-Derived Cells
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4130–4139, https://doi.org/10.4049/jimmunol.1003512
Translational Control of NKT Cell Cytokine Production by p38 MAPK
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4140–4146, https://doi.org/10.4049/jimmunol.1002614
Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4147–4155, https://doi.org/10.4049/jimmunol.1002961
CC and CXC Chemokines Induce Airway Smooth Muscle Proliferation and Survival
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4156–4163, https://doi.org/10.4049/jimmunol.1001210
Embryonic Stem Cells, Derived Either after In Vitro Fertilization or Nuclear Transfer, Prolong Survival of Semiallogeneic Heart Transplants
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4164–4174, https://doi.org/10.4049/jimmunol.1000654
The Tachykinins Substance P and Hemokinin-1 Favor the Generation of Human Memory Th17 Cells by Inducing IL-1β, IL-23, and TNF-Like 1A Expression by Monocytes
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4175–4182, https://doi.org/10.4049/jimmunol.1002535
Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4183–4190, https://doi.org/10.4049/jimmunol.1002802
Rapid Reconstitution of Antibody Responses Following Transplantation of Purified Allogeneic Hematopoietic Stem Cells
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4191–4199, https://doi.org/10.4049/jimmunol.1003674
Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4200–4212, https://doi.org/10.4049/jimmunol.1001783
A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4213–4222, https://doi.org/10.4049/jimmunol.1003585
Antibody-Mediated Coengagement of FcγRIIb and B Cell Receptor Complex Suppresses Humoral Immunity in Systemic Lupus Erythematosus
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4223–4233, https://doi.org/10.4049/jimmunol.1003412
Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4234–4243, https://doi.org/10.4049/jimmunol.1003668
ADAM10 Overexpression Shifts Lympho- and Myelopoiesis by Dysregulating Site 2/Site 3 Cleavage Products of Notch
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4244–4252, https://doi.org/10.4049/jimmunol.1003318
The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4253–4262, https://doi.org/10.4049/jimmunol.0903794
Molecular and Structural Immunology
Chaperone Activity of α B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4263–4268, https://doi.org/10.4049/jimmunol.1003934
Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4269–4277, https://doi.org/10.4049/jimmunol.1003802
Immunogenetics
Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4278–4284, https://doi.org/10.4049/jimmunol.1003733
A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4285–4294, https://doi.org/10.4049/jimmunol.1003898
Host Defense
Strongyloides ratti Infection Induces Expansion of Foxp3+ Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4295–4305, https://doi.org/10.4049/jimmunol.1001920
Alcohol Suppresses the Granulopoietic Response to Pulmonary Streptococcus pneumoniae Infection with Enhancement of STAT3 Signaling
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4306–4313, https://doi.org/10.4049/jimmunol.1002885
TLR8 Activates HIV from Latently Infected Cells of Myeloid-Monocytic Origin Directly via the MAPK Pathway and from Latently Infected CD4+ T Cells Indirectly via TNF-α
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4314–4324, https://doi.org/10.4049/jimmunol.1003174
Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4325–4330, https://doi.org/10.4049/jimmunol.1004048
Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4331–4339, https://doi.org/10.4049/jimmunol.1003057
Inflammation
α7-Cholinergic Receptor Mediates Vagal Induction of Splenic Norepinephrine
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4340–4346, https://doi.org/10.4049/jimmunol.1003722
Sphingosylphosphorylcholine Stimulates CCL2 Production from Human Umbilical Vein Endothelial Cells
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4347–4353, https://doi.org/10.4049/jimmunol.1002068
Cross Talk between Glucocorticoid and Estrogen Receptors Occurs at a Subset of Proinflammatory Genes
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4354–4360, https://doi.org/10.4049/jimmunol.1002205
Platelets Participate in Synovitis via Cox-1–Dependent Synthesis of Prostacyclin Independently of Microparticle Generation
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4361–4366, https://doi.org/10.4049/jimmunol.1002857
Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4367–4374, https://doi.org/10.4049/jimmunol.0903617
The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4375–4387, https://doi.org/10.4049/jimmunol.1003020
IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4388–4395, https://doi.org/10.4049/jimmunol.1003251
N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4396–4404, https://doi.org/10.4049/jimmunol.1001620
GroEL1, a Heat Shock Protein 60 of Chlamydia pneumoniae, Induces Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Expression in Endothelial Cells and Enhances Atherogenesis in Hypercholesterolemic Rabbits
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4405–4414, https://doi.org/10.4049/jimmunol.1003116
IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by Astrocytes
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4415–4421, https://doi.org/10.4049/jimmunol.1003307
Rapid Recruitment and Activation of Macrophages by Anti-Gal/α-Gal Liposome Interaction Accelerates Wound Healing
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4422–4432, https://doi.org/10.4049/jimmunol.1002324
Secretory Leukocyte Protease Inhibitor Plays an Important Role in the Regulation of Allergic Asthma in Mice
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4433–4442, https://doi.org/10.4049/jimmunol.1001539
β2-Adrenergic Receptor Activation Prevents Rodent Dopaminergic Neurotoxicity by Inhibiting Microglia via a Novel Signaling Pathway
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4443–4454, https://doi.org/10.4049/jimmunol.1002449
Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4455–4466, https://doi.org/10.4049/jimmunol.1000833
Low-Dose Endotoxin Induces Inflammation by Selectively Removing Nuclear Receptors and Activating CCAAT/Enhancer-Binding Protein δ
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4467–4473, https://doi.org/10.4049/jimmunol.1003300
Clinical Immunology
Dermatitis Herpetiformis Sera or Goat Anti–Transglutaminase-3 Transferred to Human Skin-Grafted Mice Mimics Dermatitis Herpetiformis Immunopathology
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4474–4480, https://doi.org/10.4049/jimmunol.1003273
Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4481–4489, https://doi.org/10.4049/jimmunol.1000148
Invariant NKT Cell Reconstitution in Pediatric Leukemia Patients Given HLA-Haploidentical Stem Cell Transplantation Defines Distinct CD4+ and CD4− Subset Dynamics and Correlates with Remission State
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4490–4499, https://doi.org/10.4049/jimmunol.1003748
Decreased Thymic Output Accounts for Decreased Naive T Cell Numbers in Children with Down Syndrome
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4500–4507, https://doi.org/10.4049/jimmunol.1001700
Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4508–4517, https://doi.org/10.4049/jimmunol.1000340
B Cells as a Therapeutic Target for IFN-β in Relapsing–Remitting Multiple Sclerosis
The Journal of Immunology, Volume 186, Issue 7, April 2011, Pages 4518–4526, https://doi.org/10.4049/jimmunol.1000271
Corrections
Correction: Absent Bactericidal Activity of Mouse Serum Against Invasive African Nontyphoidal Salmonella Results from Impaired Complement Function but Not a Lack of Antibody
The Journal of Immunology, Volume 186, Issue 7, April 2011, Page 4527, https://doi.org/10.4049/jimmunol.1190008
