Volume 181, Issue 10
November 2008
Cover image
Cover image
On the cover: Cutaneous lesions in MRL-Faslpr mice (5 mo of age) resemble the verrucoid variant of human discoid lupus, characterized by interface vacuolar changes with apoptotic keratinocytes, acanthosis with hyperkeratosis/hypergranulosis and follicular plugging, and a superficial and deep lymphohistiocytic infiltrate with associated scarring alopecia (refer to Fig. 1 on page 7369; H&E, ×40). Menke, J., M.-Y. Hsu, K. T. Byrne, J. A. Lucas, W. A. Rabacal, B. P. Croker, X.-H. Zong, E. R. Stanley, and V. R. Kelley. 2008. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Faslpr mice. J. Immunol. 181: 7367–7379.
ISSN 0022-1767
EISSN 1550-6606
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Volume 181, Issue 10, November 2008
In This Issue
In This Issue
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6677–6678, https://doi.org/10.4049/jimmunol.181.10.6677
Brief Reviews
Mechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6679–6685, https://doi.org/10.4049/jimmunol.181.10.6679
Cutting Edge
Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6687–6691, https://doi.org/10.4049/jimmunol.181.10.6687
Cutting Edge: Eosinophils Do Not Contribute to Respiratory Syncytial Virus Vaccine-Enhanced Disease
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6692–6696, https://doi.org/10.4049/jimmunol.181.10.6692
Cutting Edge: Helminth Infection Induces IgE in the Absence of μ- or δ-Chain Expression
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6697–6701, https://doi.org/10.4049/jimmunol.181.10.6697
Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6702–6706, https://doi.org/10.4049/jimmunol.181.10.6702
Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6707–6710, https://doi.org/10.4049/jimmunol.181.10.6707
Cellular Immunology and Immune Regulation
Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6711–6719, https://doi.org/10.4049/jimmunol.181.10.6711
TLR Ligands in the Local Treatment of Established Intracerebral Murine Gliomas
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6720–6729, https://doi.org/10.4049/jimmunol.181.10.6720
Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6730–6737, https://doi.org/10.4049/jimmunol.181.10.6730
The Common γ-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6738–6746, https://doi.org/10.4049/jimmunol.181.10.6738
Aging Impairs IFN Regulatory Factor 7 Up-Regulation in Plasmacytoid Dendritic Cells during TLR9 Activation
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6747–6756, https://doi.org/10.4049/jimmunol.181.10.6747
Reversible Blockade of Thymic Output: An Inherent Part of TLR Ligand-Mediated Immune Response
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6757–6769, https://doi.org/10.4049/jimmunol.181.10.6757
Adaptable TCR Avidity Thresholds for Negative Selection
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6770–6778, https://doi.org/10.4049/jimmunol.181.10.6770
Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6779–6788, https://doi.org/10.4049/jimmunol.181.10.6779
Enhanced Early Expansion and Maturation of Semi-Invariant NK T Cells Inhibited Autoimmune Pathogenesis in Congenic Nonobese Diabetic Mice
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6789–6796, https://doi.org/10.4049/jimmunol.181.10.6789
IFN-β Production by TLR4-Stimulated Innate Immune Cells Is Negatively Regulated by GSK3-β
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6797–6802, https://doi.org/10.4049/jimmunol.181.10.6797
Ion Channels Modulating Mouse Dendritic Cell Functions
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6803–6809, https://doi.org/10.4049/jimmunol.181.10.6803
Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6810–6819, https://doi.org/10.4049/jimmunol.181.10.6810
The Host Environment Regulates the Function of CD8+ Graft-versus-Host-Reactive Effector Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6820–6828, https://doi.org/10.4049/jimmunol.181.10.6820
Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between FcγRI and FcγRIV
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6829–6836, https://doi.org/10.4049/jimmunol.181.10.6829
IL-21 Stimulates Human Myeloma Cell Growth through an Autocrine IGF-1 Loop
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6837–6842, https://doi.org/10.4049/jimmunol.181.10.6837
MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6843–6849, https://doi.org/10.4049/jimmunol.181.10.6843
Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6850–6858, https://doi.org/10.4049/jimmunol.181.10.6850
Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6859–6871, https://doi.org/10.4049/jimmunol.181.10.6859
Antiviral-Activated Dendritic Cells: A Paracrine-Induced Response State
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6872–6881, https://doi.org/10.4049/jimmunol.181.10.6872
PI4P5-Kinase Iα Is Required for Efficient HIV-1 Entry and Infection of T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6882–6888, https://doi.org/10.4049/jimmunol.181.10.6882
Differential Regulatory Function of Resting and Preactivated Allergen-Specific CD4+CD25+ Regulatory T Cells in Th2-Type Airway Inflammation
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6889–6897, https://doi.org/10.4049/jimmunol.181.10.6889
Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6898–6905, https://doi.org/10.4049/jimmunol.181.10.6898
Neuropeptide Y Is Expressed by Rat Mononuclear Blood Leukocytes and Strongly Down-Regulated during Inflammation
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6906–6912, https://doi.org/10.4049/jimmunol.181.10.6906
Transgenic Mice Expressing Dominant-Negative Bright Exhibit Defects in B1 B Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6913–6922, https://doi.org/10.4049/jimmunol.181.10.6913
CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6923–6933, https://doi.org/10.4049/jimmunol.181.10.6923
Rapid and Selective Expansion of Nonclonotypic T Cells in Regulatory T Cell-Deficient, Foreign Antigen-Specific TCR-Transgenic Scurfy Mice: Antigen-Dependent Expansion and TCR Analysis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6934–6941, https://doi.org/10.4049/jimmunol.181.10.6934
Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6942–6954, https://doi.org/10.4049/jimmunol.181.10.6942
Imatinib Mesylate Inhibits CD4+CD25+ Regulatory T Cell Activity and Enhances Active Immunotherapy against BCR-ABL− Tumors
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6955–6963, https://doi.org/10.4049/jimmunol.181.10.6955
IFN-γ-Dependent Regulatory Circuits in Immune Inflammation Highlighted in Diabetes
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6964–6974, https://doi.org/10.4049/jimmunol.181.10.6964
Targeting CD4 Coreceptor Expression to Postselection Thymocytes Reveals That CD4/CD8 Lineage Choice Is neither Error-Prone nor Stochastic
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6975–6983, https://doi.org/10.4049/jimmunol.181.10.6975
CD4+ and CD8+ T Cells Exhibit Differential Requirements for CCR7-Mediated Antigen Transport during Influenza Infection
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6984–6994, https://doi.org/10.4049/jimmunol.181.10.6984
Dynamin 2 Regulates Granule Exocytosis during NK Cell-Mediated Cytotoxicity
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 6995–7001, https://doi.org/10.4049/jimmunol.181.10.6995
Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-α and Epidermal Growth Factor
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7002–7013, https://doi.org/10.4049/jimmunol.181.10.7002
Thymocyte-Dendritic Cell Interactions near Sources of CCR7 Ligands in the Thymic Cortex
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7014–7023, https://doi.org/10.4049/jimmunol.181.10.7014
Molecular and Structural Immunology
A Novel C1q Family Member of Amphioxus Was Revealed to Have a Partial Function of Vertebrate C1q Molecule
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7024–7032, https://doi.org/10.4049/jimmunol.181.10.7024
CD45 Down-Regulates Lck-Mediated CD44 Signaling and Modulates Actin Rearrangement in T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7033–7043, https://doi.org/10.4049/jimmunol.181.10.7033
Hyaluronan Induces Cell Death in Activated T Cells through CD44
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7044–7054, https://doi.org/10.4049/jimmunol.181.10.7044
Negative Regulation of TCR Signaling by Linker for Activation of X Cells via Phosphotyrosine-Dependent and -Independent Mechanisms
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7055–7061, https://doi.org/10.4049/jimmunol.181.10.7055
Processing of an Antigenic Sequence from IgG Constant Domains for Presentation by MHC Class II
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7062–7072, https://doi.org/10.4049/jimmunol.181.10.7062
Immunogenetics
NKG2D-RAE-1 Receptor-Ligand Variation Does Not Account for the NK Cell Defect in Nonobese Diabetic Mice
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7073–7080, https://doi.org/10.4049/jimmunol.181.10.7073
Host Defense
Induction of TRAIL- and TNF-α-Dependent Apoptosis in Human Monocyte-Derived Dendritic Cells by Microfilariae of Brugia malayi
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7081–7089, https://doi.org/10.4049/jimmunol.181.10.7081
Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7090–7099, https://doi.org/10.4049/jimmunol.181.10.7090
Aspergillus Conidia Activate the Complement by the Mannan-Binding Lectin C2 Bypass Mechanism
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7100–7105, https://doi.org/10.4049/jimmunol.181.10.7100
Histoplasma capsulatum Cyclophilin A Mediates Attachment to Dendritic Cell VLA-5
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7106–7114, https://doi.org/10.4049/jimmunol.181.10.7106
IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7115–7120, https://doi.org/10.4049/jimmunol.181.10.7115
A Novel Role for Neutrophils As Critical Activators of NK Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7121–7130, https://doi.org/10.4049/jimmunol.181.10.7121
TNF-α Is a Positive Regulatory Factor for Human Vγ2Vδ2 T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7131–7137, https://doi.org/10.4049/jimmunol.181.10.7131
Species-Specific Interaction of Streptococcus pneumoniae with Human Complement Factor H
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7138–7146, https://doi.org/10.4049/jimmunol.181.10.7138
Role of Human CD36 in Bacterial Recognition, Phagocytosis, and Pathogen-Induced JNK-Mediated Signaling
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7147–7156, https://doi.org/10.4049/jimmunol.181.10.7147
NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7157–7165, https://doi.org/10.4049/jimmunol.181.10.7157
The ESX-5 Secretion System of Mycobacterium marinum Modulates the Macrophage Response
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7166–7175, https://doi.org/10.4049/jimmunol.181.10.7166
Inflammation
TLR/MyD88 and Liver X Receptor α Signaling Pathways Reciprocally Control Chlamydia pneumoniae-Induced Acceleration of Atherosclerosis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7176–7185, https://doi.org/10.4049/jimmunol.181.10.7176
Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7186–7193, https://doi.org/10.4049/jimmunol.181.10.7186
Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7194–7204, https://doi.org/10.4049/jimmunol.181.10.7194
Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7205–7213, https://doi.org/10.4049/jimmunol.181.10.7205
IL-10 and TGF-β Redundantly Protect against Severe Liver Injury and Mortality during Acute Schistosomiasis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7214–7220, https://doi.org/10.4049/jimmunol.181.10.7214
CD4+CD25+ Foxp3+ Regulatory T Cells Protect against T Cell-Mediated Fulminant Hepatitis in a TGF-β-Dependent Manner in Mice
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7221–7229, https://doi.org/10.4049/jimmunol.181.10.7221
Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7230–7242, https://doi.org/10.4049/jimmunol.181.10.7230
Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7243–7253, https://doi.org/10.4049/jimmunol.181.10.7243
Fibrillar Amyloid-β Peptides Activate Microglia via TLR2: Implications for Alzheimer’s Disease
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7254–7262, https://doi.org/10.4049/jimmunol.181.10.7254
TGF-β1 Attenuates Mediator Release and De Novo Kit Expression by Human Skin Mast Cells through a Smad-Dependent Pathway
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7263–7272, https://doi.org/10.4049/jimmunol.181.10.7263
Prostaglandin E2 Inhibits Eosinophil Trafficking through E-Prostanoid 2 Receptors
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7273–7283, https://doi.org/10.4049/jimmunol.181.10.7273
NF-κB-Driven STAT2 and CCL2 Expression in Astrocytes in Response to Brain Injury
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7284–7291, https://doi.org/10.4049/jimmunol.181.10.7284
Pleural Mesothelial Cells Express Both BLT2 and PPARα and Mount an Integrated Response to Pleural Leukotriene B4
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7292–7299, https://doi.org/10.4049/jimmunol.181.10.7292
The Effect of the JNK Inhibitor, JIP Peptide, on Human T Lymphocyte Proliferation and Cytokine Production
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7300–7306, https://doi.org/10.4049/jimmunol.181.10.7300
A New Mechanism for Inhalational Priming: IL-4 Bypasses Innate Immune Signals
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7307–7315, https://doi.org/10.4049/jimmunol.181.10.7307
Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7316–7323, https://doi.org/10.4049/jimmunol.181.10.7316
Active Caspase-1-Mediated Secretion of Retinoic Acid Inducible Gene-I
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7324–7331, https://doi.org/10.4049/jimmunol.181.10.7324
Induction of Scavenger Receptor Class B Type I Is Critical for Simvastatin Enhancement of High-Density Lipoprotein-Induced Anti-Inflammatory Actions in Endothelial Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7332–7340, https://doi.org/10.4049/jimmunol.181.10.7332
Oncostatin M-Induced and Constitutive Activation of the JAK2/STAT5/CIS Pathway Suppresses CCL1, but Not CCL7 and CCL8, Chemokine Expression
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7341–7349, https://doi.org/10.4049/jimmunol.181.10.7341
Clinical Immunology
The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7350–7355, https://doi.org/10.4049/jimmunol.181.10.7350
Measles Virus Infection in Adults Induces Production of IL-10 and Is Associated with Increased CD4+CD25+ Regulatory T Cells
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7356–7366, https://doi.org/10.4049/jimmunol.181.10.7356
Sunlight Triggers Cutaneous Lupus through a CSF-1-Dependent Mechanism in MRL-Faslpr Mice
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7367–7379, https://doi.org/10.4049/jimmunol.181.10.7367
Breaking of CD8+ T Cell Tolerance through In Vivo Ligation of CD40 Results in Inhibition of Chronic Graft-versus-Host Disease and Complete Donor Cell Engraftment
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7380–7389, https://doi.org/10.4049/jimmunol.181.10.7380
Intestinal Macrophage/Epithelial Cell-Derived CCL11/Eotaxin-1 Mediates Eosinophil Recruitment and Function in Pediatric Ulcerative Colitis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7390–7399, https://doi.org/10.4049/jimmunol.181.10.7390
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7400–7406, https://doi.org/10.4049/jimmunol.181.10.7400
Multiple Glycines in TCR α-Chains Determine Clonally Diverse Nature of Human T Cell Memory to Influenza A Virus
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7407–7419, https://doi.org/10.4049/jimmunol.181.10.7407
Low Expression of the IL-23/Th17 Pathway in Atopic Dermatitis Compared to Psoriasis
The Journal of Immunology, Volume 181, Issue 10, November 2008, Pages 7420–7427, https://doi.org/10.4049/jimmunol.181.10.7420
Corrections
Sodium-dependent glucose transporter-1 as a novel immunological player in the intestinal mucosa
The Journal of Immunology, Volume 181, Issue 10, November 2008, Page 7428, https://doi.org/10.4049/jimmunol.181.10.7428
CD8 T cells utilize TRAIL to control influenza virus infection
The Journal of Immunology, Volume 181, Issue 10, November 2008, Page 7428, https://doi.org/10.4049/jimmunol.181.10.7428-a
Expression of a soluble TGF-β receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacy
The Journal of Immunology, Volume 181, Issue 10, November 2008, Page 7428, https://doi.org/10.4049/jimmunol.181.10.7428-b
