Volume 181, Issue 11
December 2008
Cover image
Cover image
On the cover: Langerhans dendritic cells in the skin. Immunofluorescence staining of MHC class II (green) and langerin (blue) in epidermal sheets freshly isolated from the ear skin of a normal adult mouse. Confocal images show that all MHCII+ cells in the epidermis express langerin and are called Langerhans cells. Eriksson, A. U., and R. R. Singh. 2008. Cutting Edge: Migration of Langerhans dendritic cells is impaired in autoimmune dermatitis. J. Immunol. 181: 7468–7472.
ISSN 0022-1767
EISSN 1550-6606
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Volume 181, Issue 11, December 2008
Pillars Article: Generation of T-cell Function in Organ Culture of Foetal Mouse Thymus. I. Mitogen Responsiveness
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7437–7444, https://doi.org/10.4049/jimmunol_181_11_8237
In This Issue
In This Issue
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7433–7434, https://doi.org/10.4049/jimmunol.181.11.7433
Pillars of Immunology
Bringing the Thymus to the Bench
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7435–7436, https://doi.org/10.4049/jimmunol.181.11.7435
Pillars Article: Generation of T-cell Function in Organ Culture of Foetal Mouse Thymus. I. Mitogen Responsiveness
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7437–7444, https://doi.org/10.1093/jimmunol/181.11.7437
Cutting Edge
Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7445–7448, https://doi.org/10.4049/jimmunol.181.11.7445
Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b+CD11c− APC
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7449–7452, https://doi.org/10.4049/jimmunol.181.11.7449
Cutting Edge: Viral Infection Breaks NK Cell Tolerance to “Missing Self”
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7453–7457, https://doi.org/10.4049/jimmunol.181.11.7453
Cutting Edge: Selective Blockade of LIGHT-Lymphotoxin β Receptor Signaling Protects Mice from Experimental Cerebral Malaria Caused by Plasmodium berghei ANKA
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7458–7462, https://doi.org/10.4049/jimmunol.181.11.7458
Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7463–7467, https://doi.org/10.4049/jimmunol.181.11.7463
Cutting Edge: Migration of Langerhans Dendritic Cells Is Impaired in Autoimmune Dermatitis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7468–7472, https://doi.org/10.4049/jimmunol.181.11.7468
Cellular Immunology and Immune Regulation
Requirement of IL-17RA in Con A Induced Hepatitis and Negative Regulation of IL-17 Production in Mouse T Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7473–7479, https://doi.org/10.4049/jimmunol.181.11.7473
Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7480–7488, https://doi.org/10.4049/jimmunol.181.11.7480
NK Cells Induce Apoptosis in Tubular Epithelial Cells and Contribute to Renal Ischemia-Reperfusion Injury
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7489–7498, https://doi.org/10.4049/jimmunol.181.11.7489
Inhibition of the Alloimmune Response through the Generation of Regulatory T Cells by a MHC Class II-Derived Peptide
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7499–7506, https://doi.org/10.4049/jimmunol.181.11.7499
Lin−Sca1+Kit− Bone Marrow Cells Contain Early Lymphoid-Committed Precursors That Are Distinct from Common Lymphoid Progenitors
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7507–7513, https://doi.org/10.4049/jimmunol.181.11.7507
Resolution of Unique Sca-1highc-Kit− Lymphoid-Biased Progenitors in Adult Bone Marrow
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7514–7524, https://doi.org/10.4049/jimmunol.181.11.7514
Retinal Pigment Epithelium-Derived CTLA-2α Induces TGFβ-Producing T Regulatory Cells,
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7525–7536, https://doi.org/10.4049/jimmunol.181.11.7525
Deregulation of c-Myc Confers Distinct Survival Requirements for Memory B Cells, Plasma Cells, and Their Progenitors
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7537–7549, https://doi.org/10.4049/jimmunol.181.11.7537
Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7550–7561, https://doi.org/10.4049/jimmunol.181.11.7550
Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7562–7570, https://doi.org/10.4049/jimmunol.181.11.7562
Transplantation of Bone Marrow Transduced to Express Self-Antigen Establishes Deletional Tolerance and Permanently Remits Autoimmune Disease
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7571–7580, https://doi.org/10.4049/jimmunol.181.11.7571
A New Approach to the Blocking of Alloreactive T Cell-Mediated Graft-versus-Host Disease by In Vivo Administration of Anti-CXCR3 Neutralizing Antibody
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7581–7592, https://doi.org/10.4049/jimmunol.181.11.7581
Drak2 Regulates the Survival of Activated T Cells and Is Required for Organ-Specific Autoimmune Disease
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7593–7605, https://doi.org/10.4049/jimmunol.181.11.7593
Enhanced T Cell Apoptosis within Drak2-Deficient Mice Promotes Resistance to Autoimmunity
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7606–7616, https://doi.org/10.4049/jimmunol.181.11.7606
The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7617–7629, https://doi.org/10.4049/jimmunol.181.11.7617
The Immunosuppressor Mycophenolic Acid Kills Activated Lymphocytes by Inducing a Nonclassical Actin-Dependent Necrotic Signal
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7630–7638, https://doi.org/10.4049/jimmunol.181.11.7630
Signals and Sequences That Control CD28 Localization to the Central Region of the Immunological Synapse
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7639–7648, https://doi.org/10.4049/jimmunol.181.11.7639
Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7649–7659, https://doi.org/10.4049/jimmunol.181.11.7649
Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7660–7669, https://doi.org/10.4049/jimmunol.181.11.7660
Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-α/β
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7670–7680, https://doi.org/10.4049/jimmunol.181.11.7670
Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7681–7688, https://doi.org/10.4049/jimmunol.181.11.7681
Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7689–7698, https://doi.org/10.4049/jimmunol.181.11.7689
The Role of Thymic Stromal Lymphopoietin in CD8+ T Cell Homeostasis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7699–7705, https://doi.org/10.4049/jimmunol.181.11.7699
The Phosphoinositide 3-Kinase-Dependent Activation of Btk Is Required for Optimal Eicosanoid Production and Generation of Reactive Oxygen Species in Antigen-Stimulated Mast Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7706–7712, https://doi.org/10.4049/jimmunol.181.11.7706
An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7713–7720, https://doi.org/10.4049/jimmunol.181.11.7713
Enhancement in Specific CD8+ T Cell Recognition of EphA2+ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7721–7727, https://doi.org/10.4049/jimmunol.181.11.7721
Self-Antigen Prevents CD8 T Cell Effector Differentiation by CD134 and CD137 Dual Costimulation
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7728–7737, https://doi.org/10.4049/jimmunol.181.11.7728
Photoaffinity Antigens for Human γδ T Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7738–7750, https://doi.org/10.4049/jimmunol.181.11.7738
Coexpression of TGF-β1 and IL-10 Enables Regulatory T Cells to Completely Suppress Airway Hyperreactivity
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7751–7758, https://doi.org/10.4049/jimmunol.181.11.7751
Rapid Deletion of Antigen-Specific CD4+ T Cells following Infection Represents a Strategy of Immune Evasion and Persistence for Anaplasma marginale
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7759–7769, https://doi.org/10.4049/jimmunol.181.11.7759
T Cell-Independent Spontaneous Loss of Tolerance by Anti-Double-Stranded DNA B Cells in C57BL/6 Mice
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7770–7777, https://doi.org/10.4049/jimmunol.181.11.7770
Egr2 Is Required for Bcl-2 Induction during Positive Selection
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7778–7785, https://doi.org/10.4049/jimmunol.181.11.7778
TCR Down-Regulation Controls Virus-Specific CD8+ T Cell Responses
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7786–7799, https://doi.org/10.4049/jimmunol.181.11.7786
TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7800–7809, https://doi.org/10.4049/jimmunol.181.11.7800
Granzyme C Supports Efficient CTL-Mediated Killing Late in Primary Alloimmune Responses
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7810–7817, https://doi.org/10.4049/jimmunol.181.11.7810
Molecular and Structural Immunology
The Magnitude of Thymic Output Is Genetically Determined through Controlled Intrathymic Precursor T Cell Proliferation
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7818–7824, https://doi.org/10.4049/jimmunol.181.11.7818
An Activation-Induced Cytidine Deaminase-Independent Mechanism of Secondary VH Gene Rearrangement in Preimmune Human B Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7825–7834, https://doi.org/10.4049/jimmunol.181.11.7825
Induction of A:T Mutations Is Dependent on Cellular Environment but Independent of Mutation Frequency and Target Gene Location
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7835–7842, https://doi.org/10.4049/jimmunol.181.11.7835
MHC Class II Presentation of gp100 Epitopes in Melanoma Cells Requires the Function of Conventional Endosomes and Is Influenced by Melanosomes
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7843–7852, https://doi.org/10.4049/jimmunol.181.11.7843
TCR β-Chain Sharing in Human CD8+ T Cell Responses to Cytomegalovirus and EBV
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7853–7862, https://doi.org/10.4049/jimmunol.181.11.7853
TREM-2 Mediated Signaling Induces Antigen Uptake and Retention in Mature Myeloid Dendritic Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7863–7872, https://doi.org/10.4049/jimmunol.181.11.7863
The Secretion and Uptake of Lysosomal Phospholipase A2 by Alveolar Macrophages
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7873–7881, https://doi.org/10.4049/jimmunol.181.11.7873
RGS13 Controls G Protein-Coupled Receptor-Evoked Responses of Human Mast Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7882–7890, https://doi.org/10.4049/jimmunol.181.11.7882
Host Defense
Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7891–7901, https://doi.org/10.4049/jimmunol.181.11.7891
Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7902–7908, https://doi.org/10.4049/jimmunol.181.11.7902
Mucosal Clearance of Capsule-Expressing Bacteria Requires Both TLR and Nucleotide-Binding Oligomerization Domain 1 Signaling
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7909–7916, https://doi.org/10.4049/jimmunol.181.11.7909
A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-β in Macrophages and Fibroblasts
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7917–7924, https://doi.org/10.4049/jimmunol.181.11.7917
Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7925–7935, https://doi.org/10.4049/jimmunol.181.11.7925
Multimerization of Surfactant Protein D, but Not Its Collagen Domain, Is Required for Antiviral and Opsonic Activities Related to Influenza Virus
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7936–7943, https://doi.org/10.4049/jimmunol.181.11.7936
Interaction between RANTES Promoter Variant and CCR5Δ32 Favors Recovery from Hepatitis B
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7944–7947, https://doi.org/10.4049/jimmunol.181.11.7944
Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7948–7957, https://doi.org/10.4049/jimmunol.181.11.7948
The Number of Respiratory Syncytial Virus (RSV)-Specific Memory CD8 T Cells in the Lung Is Critical for Their Ability to Inhibit RSV Vaccine-Enhanced Pulmonary Eosinophilia
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7958–7968, https://doi.org/10.4049/jimmunol.181.11.7958
OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells,
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7969–7976, https://doi.org/10.4049/jimmunol.181.11.7969
Aging Mice Exhibit a Functional Defect in Mucosal Dendritic Cell Response against an Intracellular Pathogen
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7977–7984, https://doi.org/10.4049/jimmunol.181.11.7977
Dysregulation of CXCR3 Signaling due to CXCL10 Deficiency Impairs the Antiviral Response to Herpes Simplex Virus 1 Infection
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7985–7993, https://doi.org/10.4049/jimmunol.181.11.7985
Factor C Acts as a Lipopolysaccharide-Responsive C3 Convertase in Horseshoe Crab Complement Activation,
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 7994–8001, https://doi.org/10.4049/jimmunol.181.11.7994
Inflammation
Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8002–8009, https://doi.org/10.4049/jimmunol.181.11.8002
Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8010–8017, https://doi.org/10.4049/jimmunol.181.11.8010
SOCS1 Regulates the IFN but Not NFκB Pathway in TLR-Stimulated Human Monocytes and Macrophages
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8018–8026, https://doi.org/10.4049/jimmunol.181.11.8018
Transgenic Expression of Cyclooxygenase-2 in Hepatocytes Accelerates Endotoxin-Induced Acute Liver Failure
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8027–8035, https://doi.org/10.4049/jimmunol.181.11.8027
Persistence of Lung CD8 T Cell Oligoclonal Expansions upon Smoking Cessation in a Mouse Model of Cigarette Smoke-Induced Emphysema
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8036–8043, https://doi.org/10.4049/jimmunol.181.11.8036
Multidrug Resistance-Associated Transporter 2 Regulates Mucosal Inflammation by Facilitating the Synthesis of Hepoxilin A3
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8044–8052, https://doi.org/10.4049/jimmunol.181.11.8044
Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8053–8067, https://doi.org/10.4049/jimmunol.181.11.8053
A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8068–8076, https://doi.org/10.4049/jimmunol.181.11.8068
Sulfatide, A Major Lipid Component of Myelin Sheath, Activates Inflammatory Responses As an Endogenous Stimulator in Brain-Resident Immune Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8077–8087, https://doi.org/10.4049/jimmunol.181.11.8077
CD40-Induced Signaling in Human Endothelial Cells Results in mTORC2- and Akt-Dependent Expression of Vascular Endothelial Growth Factor In Vitro and In Vivo
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8088–8095, https://doi.org/10.4049/jimmunol.181.11.8088
Clinical Immunology
Promiscuous Interaction between Gold-Specific T Cells and APCs in Gold Allergy
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8096–8102, https://doi.org/10.4049/jimmunol.181.11.8096
Deficiency of HIV-Gag-Specific T Cells in Early Childhood Correlates with Poor Viral Containment
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8103–8111, https://doi.org/10.4049/jimmunol.181.11.8103
Intrarectal Vaccination with Recombinant Vaccinia Virus Expressing Carcinoembronic Antigen Induces Mucosal and Systemic Immunity and Prevents Progression of Colorectal Cancer
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8112–8119, https://doi.org/10.4049/jimmunol.181.11.8112
Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8120–8132, https://doi.org/10.4049/jimmunol.181.11.8120
In Vivo BLyS/BAFF Neutralization Ameliorates Islet-Directed Autoimmunity in Nonobese Diabetic Mice
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8133–8144, https://doi.org/10.4049/jimmunol.181.11.8133
Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8145–8152, https://doi.org/10.4049/jimmunol.181.11.8145
Restoration of Adenosine Deaminase-Deficient Human Thymocyte Development In Vitro by Inhibition of Deoxynucleoside Kinases,
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8153–8161, https://doi.org/10.4049/jimmunol.181.11.8153
Detection of Complement Activation on Antigen Microarrays Generates Functional Antibody Profiles and Helps Characterization of Disease-Associated Changes of the Antibody Repertoire
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8162–8169, https://doi.org/10.4049/jimmunol.181.11.8162
Corrections
IL-33 induced Ag-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4
The Journal of Immunology, Volume 181, Issue 11, December 2008, Page 8170, https://doi.org/10.4049/jimmunol.181.11.8170
Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1
The Journal of Immunology, Volume 181, Issue 11, December 2008, Pages 8170–8181, https://doi.org/10.4049/jimmunol.181.11.8170-a
