... and is required for the development of obesity-associated hypertension and autonomic dysfunction. Graphical abstract Graphical abstract Accessory proteins melanocortin receptors energy homeostasis insulin sensitivity sympathetic nervous system baroreflex sensitivity blood pressure heart rate ACCEPTED...

... the sympathetic nervous system leading to hypertension. 29 10 2024 03 01 2025 18 01 2025 12 02 2025 © The Author(s) 2025. Published by Oxford University Press on behalf of American Physiological Society. 2025 This is an Open Access article distributed under...

... vmPFC and dlPFC suggests that the ipsilateral vmPFC, rather than the dlPFC, may be causing the modulation of SSNA during ipsilateral dlPFC stimulation. microneurography sympathetic nervous system transcranial alternating current stimulation ventromedial prefrontal cortex Senior Principal Research...

... remains unknown, and effective therapeutic strategies are still unavailable. Growing evidence suggests that the sympathetic nervous system regulates bone homeostasis and vascular function under psychological stress, as well as the coupling of osteogenesis and angiogenesis in bone development, remodeling...

..., and to further advance this area, the purpose of this study was to (i) quantify associations between sympathetic markers and physical symptoms in patients with moderate to advanced HF and (ii) explore sex differences in these associations. As one potential mechanism, sympathetic nervous system activation...

... pressure (BP) is well established, the detailed mechanisms for such association are still under research. For more than 30 years sympathetic nervous system (SNS) and kidney sodium reabsorption activation, secondary to insulin resistance and compensatory hyperinsulinemia, have been considered as primary...

... nervous system transcranial electrical stimulation Baker Heart and Diabetes Institute 10.13039/501100014643 The beat-to-beat regulation of blood pressure (BP) depends on baroreflex-mediated changes in the rate and force of contraction of the heart and total peripheral resistance, through increases...

... nervous system. The RVLM has been implicated in several cardiovascular disorders, including HTN, heart failure, and arrhythmia. ²⁶ Thus, we hypothesized that expression of PRR in the RVLM is required for the full development and maintenance of HTN through activation of the brain RAS. To test...

... underlying pathomechanisms. In this review article, we describe the current published data on potential underlying mechanisms associated with the onset of TTS including sympathetic nervous system over-stimulation, structural and functional alterations in the central nervous system, catecholamine secretion...

... for the dlPFC in the control of SSNA, which likely contributes to the ability of emotions to bring about cutaneous vasoconstriction and sweat release. Dorsolateral prefrontal cortex Medullary raphe Transcranial electrical stimulation Sympathetic nervous system Baker Heart and Diabetes Institute 10.13039...

... in the ventromedial hypothalamus of the mutants as compared with the controls. In agreement, sympathetic nervous system (SNS) output, visualized by tyrosine hydroxylase expression, was lower in the brown adipose tissue of the mutants. In contrast, absence of TR signaling in the mutants did not affect their ability...

... guidance was used were accepted for inclusion in this review. The confluence of sympathetic nerves at the stellate ganglion makes it a target to block for pathological conditions that are sustained by increased activity of the sympathetic nervous system. Regional anesthesiologists and pain medicine...

... be associated with neurobiological imbalances or genetic variants, including central 5-hydroxytryptophan (5-HT) neurotransmitter disorders, sympathetic nervous system overactivity, penile hypersensitivity, and genetic susceptibility. ^{3 , 4} In addition, 5-hydroxytryptamine...

... investigated in a large phase III Study. Neuromodulation Autonomic regulation therapy Device-therapy Sympathetic nervous system Autonomic imbalance In the last decades, a consistent body of pre-clinical as well as clinical evidence, clearly demonstrated that sympathetic overactivation, always combined...

... of the nervous system. The regulation exerted by the sympathetic nervous system (SNS) on macrophages (and the immune system in general) is becoming a subject of increasing interest, indeed a great number of articles have been published lately. Catecholamines (noradrenaline and adrenaline) activate α and β...

... exacerbates sympathetic nerve damage. ^{5 , 6} The sympathetic nervous system (SNS) is instrumental for orchestrating inflammatory cell release from the bone marrow, which directs sympathetic innervation organ, ⁷ and the SNS also supports the bone marrow microenvironment...

... (n = 21). Diabetes Institutes Foundation 10.13039/100001584 dorsolateral prefrontal cortex sympathetic nervous system transcranial electrical stimulation Abstract Introduction Muscle sympathetic nerve activity (MSNA) controls the diameter of arterioles in skeletalmuscle, contributing...

... ESKD. nephrectomy refractory hypertension renal denervation sympathetic nervous system Uncontrolled refractory hypertension (rHTN) causes long-term vascular damage and increased mortality [ 1 ]. Advancements in antihypertensive medications have led to a significant decline in rates of rHTN over...

... of the hypothalamic-pituitary-adrenal axis (increased glucocorticoids), increased sympathoadrenal outflow (increased epinephrine), mobilization of the parasympathetic nervous system (reduced vagal outflow), activation of the sympathetic nervous system (SNS, increased norepinephrine release by the nerves) and changes...

... involvement of sympathetic neural factors in the determination of the so-called “residual risk” of the treated hypertensive patients will be finally discussed. blood pressure heart rate hypertension iron load meta-analysis microneurography renal denervation residual risk sympathetic nervous system...