... of the basal ganglia, the globus pallidus (GP) may also be involved in this regulation. SP-immunoreactive fibers and terminals, as well as NK1Rs and NK3Rs, were shown to be present in the GP. Methods The present study aimed to examine whether the SP administered into the GP can influence spatial memory...

.... With self-organizing recurrent networks, variability implies inhomogeneity in the synaptic weights, impeding the establishment of a continuous manifold of fixed points. Are continuous attractor neural networks still valid models for understanding spatial memory in the hippocampus, given such variability...

.... The Morris water maze was used to evaluate the spatial memory of the WT (3 months old: n = 6; 18 months old: n = 6 or 7) and TIAM2S-TG (3 months old: n = 7; 18 months old: n = 7) mice to assess their memory of the location of the platform hidden under the water. Its size...

... 2019 ; He et al. 2022 ), a key brain region for spatial memory ( Groc and Choquet 2020 ). Previously, we found that METH abstinence induced dCA1 neurotoxicity resulted from the weakened capacity of synaptic glutamate clearance of A1-like astrocytes at synapses, leading to cognitive impairment in METH...

... epileptic spiking across time and minimize spatial memory impairments. CI-1040 has already advanced to Phase II clinical trials as an anti-cancer agent, with few adverse effects reported, and could be readily repurposed to prevent the development of interictal spikes following brain injury. ^{40 , 41}...

.... This research aims to examine the impacts of self-initiated physical activity throughout adolescence on spatial memory. Developing mice were exposed to a 4-wk voluntary wheel running exercise protocol, commencing at the age of 30 d. After engaging in voluntary wheel running exercise during development...

... by exploratory behavior in a novel environment) is associated with cognition (novel skill learning and spatial memory) in wild male chestnut thrushes Turdus rubrocanus. Using an experimental novel skill-learning task set-up, we found that fast-exploring individuals explored the experimental device...

... to rigorously assess pigs in spatial memory paradigms, demonstrating that they use a systematic approach to foraging in an arena with multiple baited areas, and avoid revisiting areas previously explored. They also demonstrated that pigs can learn a simple left/right spatial discrimination in a T-maze. Pigs...

.... Therefore, cognitive tests that monitor deficits in spatial memory play a crucial role in evaluating animal models with early stage Alzheimer's disease. While Chinese tree shrews (Tupaia belangeri) possess many features suitable for Alzheimer's disease modeling, behavioral tests for assessing...

... entorhinal cortex observed in a matched control group. Impairments in spatial and relational cognition associated with schizophrenia may thus arise from disrupted grid firing patterns in entorhinal cortex. schizophrenia entorhinal cortex grid cells spatial memory Leverhulme Doctoral Training Programme...

... and memory. These functional alterations are correlated with morphological changes in the brain, particularly in the hippocampus, a key brain region for the formation and consolidation of spatial memory ( 1–3 ). At the molecular level, gene expression studies in aging rodents have documented significant...

... largely unexplored whether larger-brained birds perform better in learning and spatial memory tests. Here, we used two experiments (novel skill learning task and spatial memory task) to examine whether head volume (proxy for brain size) could predict the learning performance and spatial performance...

...Ana Belén Sanz-Martos; Jesús Fernández-Felipe; Beatriz Merino; Victoria Cano; Mariano Ruiz-Gayo; Nuria Del Olmo Tributyrin spatial memory LTP hippocampus synaptic transmission Significance Statement The current study investigated the effect of tributyrin, a prodrug of butyric acid, on memory...

.... chacma baboons collective decision-making dispersal home range overlap mating competition strategies spatial memory Agence Nationale de la Recherche 10.13039/501100001665 ERS-17-CE02–0008 NERC Advanced Research Fellowship How animals use space deeply affects ecological processes ( Burt...

... uncertain whether HIIT enhances hippocampal functions in terms of neurogenesis and spatial memory due to unconsidered HIIT protocol for rodents. Here, we established the HIIT regimen for rats with reference to human study. Adult male Wistar rats were assigned randomly to Control, moderate-intensity...

... < 0.05). Finally, we performed an exploratory analysis of a subgroup of individuals with Down syndrome with both imaging and neuropsychological assessments. This analysis indicated that measures of spatial memory were related to mean cortical thickness, total grey matter volume and right hemisphere...

... and multimodal magnetic resonance imaging (MRI). Inter-individual differences in CSST performance correlated with scores on an established spatial memory paradigm, but neither with episodic memory nor mnemonic discrimination, supporting specificity. Analyzing high-resolution structural MRI data, individuals...

... , 1986b) and more recently by our laboratory ( Forcelli et al. 2014 ). The HST requires long-term, nonnavigational spatial memory and is self-ordered, meaning subjects are required to track self-generated choices among a set of interdependent options. It is performed in the WGTA with the freely moving...

..., the present study shows for the first time the effect of FA maternal supplementation on memory, cytokines, and neurotrophins in the aged offspring. Aversive memory Cytokines Habituation memory Neurotrophins Spatial memory The World Health Organization recommends that women of childbearing age consume 400...

... CA3 and CA1 divisions. These results provide novel evidence that network-level dysfunction involving interactions of CA3 with CA1 is an early marker of poor cognitive outcome in aging. aging functional connectivity hippocampus spatial memory The MRI experiments were performed on a Bruker Biospin...