... secretory IgA receptor FCRL3. Secretory IgA binding to FCRL3 diminishes the inhibitory capacity of regulatory T cells and promotes a Th17-like phenotype. Here we report that in CD4⁺ regulatory T cells and CD8⁺ terminal effector T cells secretory IgA induced a shared inflammatory gene...

... in relation to eating behavior in humans. Further, the effects of exogenous OXT on AVP dynamics, which could impact safety of treatment given AVP effects on water balance, are not well understood. Objective To define secretory dynamics of circulating AVP around a standardized meal and in response to 8...

... the entire family. anatomy histochemistry latex ontogeny secretory structures Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil PID2019-108109GB-I00 MCIN/AEI/10.13039/501100011033 Laticiferous plant species have been documented by observing the exudation of a milky fluid (latex...

... responses arise and magnify in the circulation during the asymptomatic phase of RA development. This suggests mucosal involvement prior to both symptom onset and subsequent arthritis. Circulating SC ACPA does not seem to precede the IgG ACPA response. Secretory IgA is the dominant antibody at mucosal...

...) of stem and in the cortex of leaf midrib (D). sh: sheath parenchyma cells. Scale bars: A, D = 200 µm; B = 50 µm and C = 100 µm. Alt text: Light micrographs labelled A to D showing mucilage cells in cortex and pith of stem and in the pith of the leaf midrib in Peltaea polymorpha. Secretory cells...

... of leaflet anatomical characters for Machaerium systematics, to assess whether these characters support the monophyly of the Lineata clade, to identify leaflet anatomical synapomorphies for the Lineata clade, and to evaluate secretory structures present in the leaflets regarding...

.... Senescent cells exhibit cell cycle arrest, morphological changes, and increased expression and secretion of a distinct collection of proteins and bioactive molecules called the senescence-associated secretory phenotype (SASP) ( 4 ). The SASP acts locally and systemically to mediate inflammation, promote...

..., and reproduction in any medium, provided the original work is properly cited secretory carcinoma juvenile breast carcinoma salivary gland-like tumor ETV6::NTRK3 gene fusion Key Messages Secretory carcinoma is a rare, generally slow-growing, low-grade, special type of invasive breast...

... of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Targeting cellular senescence and senescence associated secretory phenotype (SASP) through autophagy has emerged as a promising intervertebral disc (IVD...

... serves as a modulator of cellular senescence and the production of the senescence-associated secretory phenotype (SASP), initiating SASP by activating the NF-κB signaling pathway, thereby triggering the cell to enter a senescent state. Stable expression of GATA4 in senescent cells is crucial...

... at Washington State University. Cre genotyping was performed as previously described ( 35 ). Details of Pgr^f/f mice and genotyping protocols have been previously published ( 36 ). Although paired box 8 (PAX8) has been used as a secretory cell marker in the oviduct, Pax8^Cre...

...Ghazanfar Ali; Kumail Ijaz; Mishal Ihsan; Muhammad Usama; Syed Muhammad Shabbir Ali Naqvi Abstract Secretory carcinoma, a triple-negative benign tumor, is one of the rarest malignancies of the breast which rarely metastasizes. Surgical excision via lumpectomy or mastectomy is the mainstay...

... treatment strategy remains unclear. Cellular senescence is a permanent state of cell-cycle arrest that can be induced by multiple stresses. Senescent cells contribute to the pathogenesis of various diseases, owing to an alteration in secretory profile, termed ‘senescence-associated secretory phenotype...

... protein-coding genes. Genes that code for known and putative polyethylene-degrading enzymes and their similarity to proteins found in other Lepidoptera are highlighted. An analysis of secretory proteins more likely to be involved in the plastic catabolic process has also been carried out. The greater wax...

... tumor, poses significant treatment challenges. Recent studies suggest that senescent cells in ACP tumors may contribute to tumor growth and invasion by releasing a senesecence-associated secretory phenotype. However, a detailed analysis of these characteristics has yet to be completed. Methods We...

... work is properly cited. Abstract   Amylosucrase (EC 2.4.1.4) is a versatile enzyme with significant potential in biotechnology and food production. To facilitate its efficient preparation, a novel expression strategy was implemented in Bacillus licheniformis for the secretory expression...

... astrocytes display a secretory phenotype known as the senescence-associated secretory phenotype (SASP), which is associated with the upregulation of various proinflammatory factors and the downregulation of neurotrophic growth factors (eg, NGF and BDNF), resulting in a decrease in astrocyte-mediated...

... senescent cells activated the innate immune response. Thus, our study sheds light on a pivotal role of migrasomes in mediating the contagiousness of aging. migrasomes cellular senescence endogenous retrovirus senescence-associated secretory phenotype aging Aging, a major risk factor of many chronic...

... of mating behavior in teleosts that functions in neuropeptide/hormone packaging to secretory granules and acts as a precursor for the neuropeptide secretoneurin (SN). By investigating the expression of scg2a (a teleost ortholog of Scg2) in a group of behaviorally relevant female-specific...

... Number: NCT01072500 Aging Biomarkers Frailty Physical function Sarcopenia Senescence-associated secretory phenotype To address these research gaps, we used longitudinal data and blood samples obtained from participants in the Lifestyle Interventions in Elders (LIFE) Study, a large, single-blind...