.../standard-publication-reuse-rights ) Abstract The present study aimed to evaluate the antioxidant protective effects of the herbal extract of Crepis rueppellii (CR) against paracetamol (PCM)–induced nephrotoxicity in guinea pigs using hematological, biochemical, histological...

.../pages/standard-publication-reuse-rights ) Abstract Importance Post traumatic pain remains poorly managed in emergency departments. Objective This study aims to evaluate the effectiveness and tolerability of a phytotherapeutic topical gel (Douloff) compared to oral paracetamol for acute pain...

... University over a period of 6 months. The diagnosis of PDA was established both clinically (hemodynamic state) and by echocardiography. The enrolled neonates were observed to evaluate PDA treatment decisions (either ibuprofen, paracetamol or conservative management). Results We found significant...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Objectives To evaluate the effect of a clinician-designed digital notification system on the use of intravenous paracetamol during...

... Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Introduction Paracetamol has a maximum daily dose of 4g/24 hours, with a lower maximum dose (60mg/kg/day) for those weighing under 50kg. Various studies have reported on the extent of supratherapeutic dosing...

... the role of pre-emptive Chlorpheniramine as an adjuvant to paracetamol in the prevention of emergence agitation in orofacial cleft repair surgeries. Studied cases& techniques: study was prospective, Randomized, Double-Blind Clinical research done at Ain-shams University Hospitals, Cairo, Egypt for 6...

... formulations and improve the poor compressibility of paracetamol (PMOL). Methods By using various amounts of polyethylene glycol (PEG), a low melting point binder and ethyl cellulose (EC) as insoluble carrier, the formation of high content of PMOL granules occurred at low processing temperatures (55°C...

... is properly cited. Abstract Background and Aims Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality. Given the major implications of these findings...

... , ahakici@gmail.com Key messages We assessed supratherapeutic use of paracetamol and ibuprofen in primary care. Potential overdosing was more likely to be practiced for paracetamol. Daily dose limit of paracetamol was exceeded in 4.4% of its prescriptions. Three-point-one percent of ibuprofen...

... 1.32; 95% CI 1.01, 1.76) comorbidities. For multimorbidity, the use of paracetamol and opioids interacted positively with KP, whereas the use of NSAIDs interacted negatively for seven comorbidities. Conclusion People with KP are more likely to have other chronic conditions. The long-term benefits...

.... For commercial re-use, please contact journals.permissions@oup.com Abstract Context Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine disruptor since in utero exposure may be associated with a higher risk...

... Objectives Acetaminophen (APAP) (paracetamol) is a widely used non-prescription drug for pain relief and antipyretic effects. The clearance of APAP is mainly through phase-2 biotransformation catalysed by UDP-glucuronosyl transferases (UGT). Dasabuvir is an anti-hepatitis C drug reported to inhibit several...

... and was observed for ductal closure after 3 days of intravenous paracetamol intervention (10-15 mg/kg) given every 8 hours. The echocardiography evaluation of PDA status was conducted after those pharmacological intervention and divided based on the gestational age group. In the preterm groups (<36 weeks), 3...

... Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstracts C31. Closure of patent ductus arteriosus using intravenous paracetamol : a case series S. Nursalim1, D. Setyawan1, M. Limbong1, F. Ahmad1...

... anesthesia, no need for deep sedation and can be used for emergency operations on extremities for patients with full stomach. Objective Comparison between the anesthetic and analgesic parameters in local intravenous anesthesia by adding Paracetamol and Dexamethasone to xylocaine. Patients and methods...

...Sarah Bloukh; Mayyada Wazaify; Catriona Matheson Paracetamol has been used therapeutically since the mid-1950s and remains the mainstay of treatment for mild pain and fever for children, pregnant women, older adults, people with non-inflammatory pain and those who are intolerant to non-steroidal...

... acute liver injury drug-induced liver failure hepatic inflammation Kupffer cells liver immunity macrophages metallothioneins mouse model paracetamol Acetaminophen (APAP), also known as paracetamol, is the most widely used antipyretic and analgesic over-the-counter drug and is also the leading...

... Paracetamol Pharmacokinetic Because of its favourable adverse effect profile ( 1 ), acetaminophen is the most commonly used analgesic and antipyretic ( 2 ) and the most commonly prescribed drug in children ( 2 , 3 ). Acetaminophen has proven opioid-sparing properties ( 4 ) and therefore, optimizing...

... multiple informants’ comparison paracetamol ADHD attention-deficit/hyperactivity disorder CI confidence interval DNBC Danish National Birth Cohort IPSW inverse probability of selection weight SDQ Strengths and Difficulties Questionnaire RR risk ratio Abstract Several...

... analgesics’, ‘pregnancy’, ‘self-medication’, ‘paracetamol’, ‘acetaminophen’, ‘diclofenac’, ‘aspirin’, ‘ibuprofen’, ‘in utero exposure’, ‘placenta drug transport’, ‘placental transporters’, ‘placenta drug metabolism’ and ‘offspring outcomes’. OUTCOMES This article examines the evidence of foetal exposure...