Latest articles

In vivo study and in silico analysis of the hepatoprotective effects of an aqueous extract of Cucurbita pepo L. (Cucurbitaceae) leaves against acetaminophen-induced liver damage and oxidative stress in Wistar rats
Koussoubé Ignace and others
Objectives The objectives were to study, in vivo , the hepatoprotective effects of Cucurbita pepo L. (Cucurbitaceae) leaves against acetaminophen-induced hepatocyte damage in Wistar rats, and to conduct an in silico analysis of molecular targets. Methods Hepatic toxicity was induced by oral ...
The behaviour and control of poloxamer activity in aqueous solution: polymer assembly, impact of bulk composition and tuneable nano formulation design
Roderick Stewart and others
Objectives Biocompatible block copolymers, due to their amphiphilic nature, offer solutions to improve drug solubility, targeting, and stability in drug delivery. However, the design and application of these constructs require critical evaluation of the impact of bulk properties on the resultant ...
Investigating the effect of polyvinylpyrrolidone-based urinary catheter coatings on spermatozoa quality
Robyn N Irwin and others
Objectives Hydrophilic-coated intermittent urinary catheters containing polyvinylpyrrolidone (PVP) are used to alleviate chronic urinary retention in individuals with neurogenic bladder dysfunction, most notably spinal cord injury (SCI) patients. However, coating delamination during catheterisation ...
Integrative evaluation of bioactive compounds from Solanum dasyphyllum as potential SARS-CoV inhibitors: in vivo toxicity and in silico pharmacokinetic insights
Elijah Oladapo Oyinloye and others
Objectives This study evaluated the in vivo toxicity and pharmacokinetic profiles of bioactive compounds in the hydromethanolic leaf extract of Solanum dasyphyllum , with reference to possible interactions with coronavirus-related molecular targets. Methods Leaves of S. dasyphyllum were air-dried, ...
Polyethylene glycol versus lactulose in the treatment of fecal impaction in children with functional constipation: a quasi-randomized study
Nirjala Aryal and others
Objectives Functional constipation is a common pediatric gastrointestinal disorder lacking an organic cause. Early diagnosis and cost-effective management are vital, especially in low- and middle-income countries like Nepal. This study compared polyethylene glycol (PEG) and lactulose in treating ...
Antifungal activities against pathogenic yeasts, including Candidozyma auris, of eight species used in Côte d’Ivoire, and bioguided identification of antifungal compounds from Octoknema borealis Hutch. & Dalziel stem barks
Nangouban Ouattara and others
Objectives This study aims to determine the in vitro antifungal activity of heptane, dichloromethane, ethyl acetate, and methanol extracts from eight medicinal plant species against pathogenic yeast strains involved in candidiasis, including Candidozyma auris whose multidrug-resistant strains ...
The effect of zeolite on acute lead toxicity in male rats
Mina Khalilzadeh and others
Background Lead is a well-documented toxic metal, historically recognized for its deleterious effects on human health. It is predominantly absorbed via the respiratory and gastrointestinal systems, resulting in clinical symptoms such as abdominal pain, constipation, irritability, and anemia. ...
Neuroprotective effect of lupeol in animal model of D-galactose induced cognitive dysfunction
Omkar Kapil and others
Objective Cognitive dysfunction is common in neurodegenerative diseases and aging, often associated with reduced antioxidant activity and increased brain inflammation. This study aimed to investigate the neuroprotective effects of lupeol, a pentacyclic triterpenoid derived from Emblica officinalis, ...
In vitro pharmacological evaluation of the antimicrobial, antioxidative, anti-inflammatory, and antibiofilm potential of carvacrol
Gustavo L da S Lima and others
Objectives Carvacrol is a phenolic monoterpenoid found in certain essential oils with a wide range of bioactivities. This study aimed to evaluate its in vitro cytotoxic, antioxidant, anti-inflammatory, antimicrobial, antibiofilm, and wound healing properties against resistant microbial strains and ...
A new chapter for RPS Pharmacy and Pharmacology Reports now Pharmaceutics and Pharmacology
Catherine M T Sherwin and Gary P Moss
We welcome high-quality research across the full spectrum of pharmaceutics and pharmacology, including: We also emphasize adherence to ARRIVE guidelines for animal studies, authentication and complete chemical characterization of natural products, transparent data/code availability, and proper ...

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