... that the synthesis of glutamate/glutamine is regulated by the mitochondrial thioredoxin (TRX) system. However, the mechanisms behind it remain unclear. Here, we demonstrated that the level of citrate and glutamate was higher in illuminated leaves from Arabidopsis mutants lacking the mitochondrial TRX o1...

... ) and DNQX (AMPA antagonist, 20 μM, Sigma) ( Honore et al. 1988 ). Abstract Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), is regulated by the excitatory amino acid transporters glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST). Following...

... Owing to the roles of glutamate in appetite, food addiction and impulsivity, this study aimed to identify medial prefrontal cortex (mPFC) glutamate as a predictor of variability in exercise response, specifically in terms of fat loss and muscle gain. Method Healthy non-exercising adult men (n=21...

..., an orally available new chemical entity, is a voltage-gated sodium channel blocker, with no biological activity at >130 CNS targets and normalizes glutamate release induced by aberrant sodium channel activity, without affecting basal glutamate levels. The combination of ineffective doses of evenamide...

... at >130 CNS targets, normalizes glutamate release [4,5,6,7] without affecting its basal levels. Preclinical experiments have indicated that it is likely to benefit patients responding inadequately or resistant to APs. Evenamide was evaluated as monotherapy or add-on to APs in animal models in which PPI...

... tested for altered spatial associations between availability of ligands for the neuroinflammation marker, translocator protein (TSPO), and the metabotropic glutamate receptor-5 (mGluR5) marker in a group of MDD patients compared with matched healthy controls (HCs). Method Ten drug-naï ve non-smoking...

... neurotransmission [3, 4, 5]. Evenamide, a selective inhibitor of voltage-gated sodium channels, is devoid of biological activity at >130 CNS targets, normalizes glutamate release without affecting basal levels, and demonstrated benefits in animal models of psychosis as monotherapy and as an add on to APs. Aim...

...]. Evenamide is a selective inhibitor of voltage-gated sodium channels, devoid of effects at more than130 CNS targets [8]. It reduces aberrant neuronal firing, normalizing excessive glutamate release without any effect on basal glutamate. Data from animal models of psychosis indicate the combination...

... and hippocampus, plays a key role in enhanced fear memory in diabetic mice. Moreover, increase in L-lactate in the amygdala and hippocampus inhibits AMPK activity, which enhances fear memory in diabetic mice possibly through activation of glutamate neurons and/or AMPA receptor function. fear memory diabetes...

... inhibitory and excitatory neurotransmitter GABA and glutamate, respectively. Beside the previous reported effects of hormonal treatment on hippocampal GABA levels, the relationship of sex hormones will be tested in a mixed (female and male) cohort and within a male and female subgroup, respectively...

...). KEGG functional enrichment analysis showed these differently expressed metabolites could be further enriched in ABC transporter, carbon metabolism, retrograde endocannabinoid signaling, and phospholipase D signaling pathway. Compared with the non-PTDM group, glutamate, diacylglycerol, and D-sorbitol...

... in the presence of antagonists of ionotropic glutamate and γ-aminobutyric acid (GABA) receptors (50 μM D-APV, 10 μM CNQX, and 100 μM picrotoxin). The membrane potential of neurons was subsequently maintained at −70 mV by direct current injection. The excitability of neurons was assessed by injecting depolarizing...

...-B397 by adjusting fermentation conditions, including temperature (25–37 °C), pH (3.0–6.0), monosodium glutamate (MSG) concentration (0–1 M) and fermented time (0–72 hr). The effects of these factors on bacterial cell density and GABA content were assessed over the fermentation period. Furthermore...

...) against toxicity of glutamate-induced endoplasmic reticulum (ER) stress and cell death in human microglial HMC3 cells, as well as evaluated the longevity and antioxidant effects of BAL in Caenorhabditis elegans. The BAL was obtained from the in vitro digestion of A. lebbeck leaf...

...Dan He; Ying Zhang; Jinxu Liu; Xiao Wang; Yunlong Hu; Weihui Xu; Wenjing Chen; Zhenyu Fan; Zhigang Wang Monosodium glutamate is widely utilized as a flavour enhancer and preservative in the global food industry (Moldovan et al. 2021 , Yachmin et al. 2021 ). However, the escalating issue...

... ferroptosis piperlongumine nuclear factor erythroid 2-related factor 2 gene cystine/glutamate transporter glutathione peroxidase 4 prostaglandin-endoperoxide synthase 2 Glioblastoma multiforme (GBM) is the most common primary malignant tumor in the brain, accounting for 47.1% of cases. According...

... on our site—for further information please contact [email protected]. Abstract The results from a pilot, 1-year, randomized, open-label, add-on treatment study in treatment-resistant schizophrenia (TRS) with evenamide, a glutamate modulator, were not associated with any safety abnormalities...

...Tadao Oikawa; Kazuya Yamanaka Correspondence: Tadao Oikawa, [email protected] Graphical Abstract Figure. Modeling of the monomeric structure and molecular phylogenetic analysis of L-glutamate oxidase from the marine...

... ( https://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] vocal learning conserved fragments glutamate receptor...

... interacts with glutamate N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, regulating their synaptic trafficking and composition independently of VACCs. ^{6 , 9-11} Clinical studies indicate that gabapentinoids cause gait...