... function in vitro and in vivo. iSP1 successfully interfered with STAP-1–LCK binding and suppressed TCR-mediated signal transduction, interleukin-2 production, and human and murine T cell proliferation. Additionally, iSP1 prevented the progression of experimental autoimmune encephalomyelitis by inhibiting...

... these tissues. We discovered that LNs actively synthesize 17β-estradiol, but this activity declines with age. Targeted delivery of an aromatase inhibitor specifically to LNs induced an interferon-β-resistant experimental autoimmune encephalomyelitis (EAE) phenotype. This phenotype was accompanied by significant...

... is known to cause a neurodegenerative disease, hereditary spastic paraplegia type 5 and oxysterol accumulation. However, the role of CYP7B1 in neuroinflammation has been little revealed. In this study, we induced experimental autoimmune encephalomyelitis (EAE), as a murine model of MS, using CYP7B1...

... disease conditions of experimental autoimmune encephalomyelitis, an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal cord. Gpr141  ^−/− mice showed increased CD11b ⁺ Gr1⁺ neutrophils, CD11b ⁺ Gr1...

... medium, provided the original work is properly cited. Abstract Nogo receptor 1 is the high affinity receptor for the potent myelin-associated inhibitory factors that make up part of the inflammatory extracellular milieu during experimental autoimmune encephalomyelitis. Signalling through the Nogo...

... to neuroinflammation remains understudied. Here, we show that Mcam identifies inflammatory brain endothelial cells with pro-migratory transcriptomic signature during experimental autoimmune encephalomyelitis. In addition, MCAM was preferentially upregulated on blood–brain barrier endothelial cells in multiple...

... lent support to the efficacy of KD in the prevention and treatment of experimental autoimmune encephalomyelitis and toxin-induced inflammatory demyelinating conditions in the brain. Furthermore, the animal studies have yielded mechanistic insights into the molecular mechanisms of KD action in relevant...

... the use of S100B inhibition for effective multiple sclerosis treatment. Graphical Abstract Graphical Abstract Video Abstract 10.1093/brain/fcac076_video1 Video Abstract fcac076media1 6305837788112 multiple sclerosis experimental autoimmune encephalomyelitis S100B neuroinflammation immunity ©...

... colony-stimulating factor, pro-inflammatory factors driving lymphocyte entry and pathogenicity in multiple sclerosis and experimental autoimmune encephalomyelitis, an animal model of CNS autoimmune disease. In experimental autoimmune encephalomyelitis, mice with astrocyte-specific JAM-A deletion...

...Donghui Shen; Kang Liu; Hongyan Wang; Haifeng Wang Graphical Abstract Graphical Abstract multiple sclerosis experimental autoimmune encephalomyelitis autophagy immune cells inflammatory factors Multiple sclerosis (MS) is a white matter demyelinating disease of the central nervous system...

... experimental autoimmune encephalomyelitis meta‐analysis multiple sclerosis probiotics Based on the results of the meta‐analysis, the incidence of EAE was significantly lower in mice treated with probiotics (SMD, 0·90; 95% CI, 0·83–0·96; I² = 31·6%) (Fig. 1a ). Besides, they had...

...), a typical inflammatory demyelinating disease of the CNS, and in experimental autoimmune encephalomyelitis (EAE), a typical model of MS. We determined the levels of irisin in the serum and cerebrospinal fluid in patients with MS. The expression and histological distribution of irisin were determined in EAE...

... of neurologic signs and symptoms as well the incapacities. Since the need for advances in MS treatment, many studies are for new therapeutic technologies, mainly through using preclinical models as experimental autoimmune encephalomyelitis (EAE). This study aimed to observe and analyze the development...

... of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Abstract The experimental autoimmune encephalomyelitis (EAE) model is the most commonly used animal model of multiple sclerosis (MS...

... in this crosstalk and their contribution to the pathophysiology of neuroinflammatory diseases largely elude us. Here, we show that the CNS-endogenous hedgehog pathway, a signal triggered as part of the host response during the inflammatory phase of multiple sclerosis and experimental autoimmune encephalomyelitis...

... dependent manner. ⁵ Moreover, B cells were shown to contribute to dampening inflammatory responses by secretion of regulatory cytokines including IL-10 ⁶ and IL-35, ⁷ and IgA producing plasma cells mitigated the severity of experimental autoimmune encephalomyelitis (EAE...

... homeostasis. Restoring Nrg-1β1 levels reduces disease burden in the EAE mouse model of multiple sclerosis, suggesting potential as a therapeutic target. 8 05 2020 10 08 2020 8 09 2020 neuregulin-1 multiple sclerosis experimental autoimmune encephalomyelitis immune...

... of the disease, including inflammation, oligodendrocyte apoptosis and oxidative stress. Methods The mechanism of action of shikonin was investigated in the C57BL/6 experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. Key findings The results revealed that EAE induction...

... that the reduction of CS/KS effectively improves axon regeneration. So far, it is unclear whether these GAGs influence the pathogenicity of immune diseases in the CNS. The relationship between CNS immune diseases and glycolipids has been verified using experimental autoimmune encephalomyelitis (EAE), an animal model...

... performed using the experimental autoimmune encephalomyelitis (EAE), animal model of MS. We found that serum levels of PRX5 and PRX6 in patients with MS and NMOSD were higher compared with those in patients with ONDs (P < 0·05). Furthermore, high levels of PRX5 and PRX6 were partly associated...