... function in vitro and in vivo. iSP1 successfully interfered with STAP-1–LCK binding and suppressed TCR-mediated signal transduction, interleukin-2 production, and human and murine T cell proliferation. Additionally, iSP1 prevented the progression of experimental autoimmune encephalomyelitis by inhibiting...

... allelic combinations maintained by selection. We here review experimental evolution studies on the adap- tive significance of sex and recombination in constant environments, emphasizing insights gained from population genomic data. We discuss evidence showing how meiotic segregation (sex) and crossing...

...Yanbo Zhang; Fei Pan; Kun Ni; Yanwu Zhu 3D carbon crystal structure prediction experimental preparation charge injection Corresponding author. E-mail: zhuyanwu@ustc.edu.cn 05 10 2024 02 02 2025 27 03 2025 25 04 2025 © The Author(s) 2025. Published by Oxford University Press...

... it, is a blind instrument; the head without the realizing hand remains powerless. [noted in his book Introduction à L’étude de la Médecine Expérimentale ( 66 )] The original experiments of Berthold in roosters/capons were finally repeated successfully by Albert Pézard (April 1, 1875-November 21, 1927...

... affected epithelial wound healing and/or T-cell activation. Conclusions The relative abundance changes of stromal cell subsets during experimental colitis differ between 3 established colitis models. Treatment with IBD therapies influences stromal subset abundance, indicating their importance in IBD...

... metabolic rate (RMR) and interleukin-6 (IL-6) levels. Changes in RMR reflect the energetic cost of disease, while IL-6 serves as a one of the inflammatory cytokines in the innate immune system’s response to infection. Our experimental findings reveal distinct outcomes during the acute phase of SGS1 and GRW2...

... regression analysis showed that mean annual temperature (MAT) and experimental factors (including duration and N application rates) were the primary determinants of fine root biomass response to N application. In contrast, fine root turnover was not significantly influenced by any of the factors analyzed...

... experimentally tested this hypothesis using a model microbial system: Pseudomonas fluorescens and its lytic phage. The ancestral bacterium diversified at three resource levels across eight temperature gradients in the presence and absence of phages. Bacteria diversified into more morphotypes at higher...

... Experimental evolution studies are common in agricultural research, where they are often deemed “long-term selection.” These are often used to perform selection mapping, which involves identifying markers that were putatively under selection based on finding signals of selection left in the genome. A challenge...

... cited. For commercial re-use, please contact journals.permissions@oup.com Abstract Economic experiments have gained popularity in Agricultural Economics. However, challenges in recruitment and acceptance of experimental methods among farmers persist. Surveying 406 Swedish farmers, we explore farmers...

... by binding to GABAA receptor complex (4). We aimed to investigate the chronic effects and mechanisms of action of of ZO on experimental schizophrenia models in rats and mice. Method Wistar-male rats and cd1-male mice were used in the study. ZO were administered by oral gavage chronically for 5 days...

...) and their family caregivers (55 years old, 66% female, 59% Hispanic) underwent an experimental session during which both individuals imagined a scenario where one person is hit by a car (patient) and the partner (caregiver) has no means to provide or seek out help for the victim. Results revealed that the task...

... cases. To accomplish this, we ground the problem of configuring police lineups in the theory of Bayesian sequential experimental design. Using both synthetic data and publicly available data from human-subjects studies, we find that a well-configured series can yield information greater than the sum...

... suggest that anti-Blackness undergirds the public imagination of physical spaces and has implications for understanding contemporary segregation, discrimination, and racial inequality. racial perceptions of safety anti-Black racism school choice experimental design NAED/Spencer Post Doctoral Research...

... repeatability, we experimentally evolved four replicate hybrid populations of sunflowers at natural sites for up to 14 years and tracked ancestry across the genome. We found that there was very strong negative selection against introgressed ancestry in several chromosomes, but positive selection...

... these tissues. We discovered that LNs actively synthesize 17β-estradiol, but this activity declines with age. Targeted delivery of an aromatase inhibitor specifically to LNs induced an interferon-β-resistant experimental autoimmune encephalomyelitis (EAE) phenotype. This phenotype was accompanied by significant...

...–hepatitis C coinfection interrupted time series analysis quasi-experimental methods hepatitis C virus Globally, an estimated 2.3 million people with HIV are infected with hepatitis C virus (HCV), among whom the burden of illness is greatest in people who inject drugs and men who have sex with men [ 1...

... thermal performance experimental model functions that duly account for the contributions of errors that are inherent in the collection of input experimental data. The study focuses on the uncertainty associated with the predicted thermal energy output and thermal efficiency, which were calculated by using...

... of multispecies mutualism, especially exploited mutualism, is one of the most pressing concerns in biodiversity and conservation. By applying an experimental ecological approach with yeasts, we create a synthetic exploited mutualistic system to examine the effect of dispersal on the persistence of multispecies...