Volume 96, Issue 3, Sep 2014

Discussion of how PHD3 regulates macrophage survival.

Discussion on the role of Ly6Chigh myeloid cells in suppressing inflammation during colitis.

PHD3 influences apoptotic cell survival decisions in macrophages by altered production of Angiopoietin-like protein 2.

Inflammatory monocytes recruited into chronically inflamed intestines become immunosuppressive, inhibit T cell activation and polarization toward Th1 phenotype, but promote generation of regulatory T cells.

Review of how viral infection of airway epithelial cells leading to release of Th2-promoting cytokines may drive asthma exacerbations via activation of innate lymphoid cells.

T-box transcription factor expression enables effector differentiation of self-reactive T cells upon antigen engagement, but fails to prevent their deletion.

The presence of a functional histamine H4 receptor in neutrophils with anti-inflammatory properties.

The Cebpa +37-kb enhancer directs preferential expression to myeloid, as compared to megakaryocyte/erythroid or lymphoid progenitors, and to functional long-term hematopoietic stem cells.

TRAM interaction with TRAF6 regulates the inflammatory response to TLR4 activation, and adds further intricacy to TLR signaling.

L-plastin participates in NKG2D clustering and NKG2D-mediated inhibition of NK cell chemotaxis.

Inhibition of IDO activity with 1MT treatment following influenza infection enhances the production of IL-6, TNF-α, IL-1β, and IFN-β through modulation of macrophages.

N-octanoyl dopamine displays transient T cell suppressive activity by preventing NFκB and AP-1 activation, and acts synergistically with calcineurin inhibitors on T cell proliferation.

Blocking IL-17R signaling may be a promising therapeutic strategy for the treatment of proliferative and crescentic glomerulonephritis.

Age associated lung inflammation can modify pulmonary macrophage function, which can be reversed with an ibuprofen supplemented diet.

New method for quantitative analyses of human DC migratory behavior in lung epithelial tissue.

New method to safely and effectively diminish the frequency of blood monocytes and tissue-resident macrophages in nonhuman primates.