Volume 201, Issue 9
November 2018
Cover image
Cover image
On the cover: Deletion of Csf1r in rats causes male infertility. Shown is an H&E-stained section of epididymides from an adult Csf1r-deficient rat. Pridans, C., A. Raper, G. M. Davis, J. Alves, K. A. Sauter, L. Lefevre, T. Regan, S. Meek, L. Sutherland, A. J. Thomson, S. Clohisey, S. J. Bush, R. Rojo, Z. M. Lisowski, R. Wallace, K. Grabert, K. R. Upton, Y. T. Tsai, D. Brown, L. B. Smith, K. M. Summers, N. A. Mabbott, P. Piccardo, M. T. Cheeseman, T. Burdon, and D. A. Hume. 2018. Pleiotropic impacts of macrophage and microglial deficiency on development in rats with targeted mutation of the Csf1r locus. J. Immunol. 201: 2683–2699.
ISSN 0022-1767
EISSN 1550-6606
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Volume 201, Issue 9, November 2018
In this Issue
In This Issue
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2525–2526, https://doi.org/10.4049/jimmunol.1890018
Pillars of Immunology
The Common Key to Class-Switch Recombination and Somatic Hypermutation: Discovery of AID and Its Role in Antibody Gene Diversification
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2527–2529, https://doi.org/10.4049/jimmunol.1801246
Pillars Article: Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme. Cell. 2000. 102: 553–563
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2530–2540, https://doi.org/10.1093/jimmunol/201.9.2530
Brief Reviews
The End of the Binary Era: Revisiting the Spectrum of Tuberculosis
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2541–2548, https://doi.org/10.4049/jimmunol.1800993
Cutting Edge
Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2551–2556, https://doi.org/10.4049/jimmunol.1800651
Antigen Recognition and Responses
A Novel Neutralizing Antibody Specific to the DE Loop of VP1 Can Inhibit EV-D68 Infection in Mice
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2557–2569, https://doi.org/10.4049/jimmunol.1800655
Autoimmunity
WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical Autophagy
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2570–2578, https://doi.org/10.4049/jimmunol.1800399
IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2579–2592, https://doi.org/10.4049/jimmunol.1800907
Clinical and Human Immunology
High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2593–2601, https://doi.org/10.4049/jimmunol.1800860
Immune Regulation
Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2602–2611, https://doi.org/10.4049/jimmunol.1800249
STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2612–2623, https://doi.org/10.4049/jimmunol.1700808
HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton–Mediated T Cell Functions
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2624–2640, https://doi.org/10.4049/jimmunol.1800372
B Cell–Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2641–2653, https://doi.org/10.4049/jimmunol.1701405
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2654–2663, https://doi.org/10.4049/jimmunol.1800468
Immune System Development
Peroxisome Proliferator-Activated Receptor–δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2664–2682, https://doi.org/10.4049/jimmunol.1800374
Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2683–2699, https://doi.org/10.4049/jimmunol.1701783
Immunotherapy and Vaccines
Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2700–2709, https://doi.org/10.4049/jimmunol.1701666
Infectious Disease and Host Response
Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2710–2720, https://doi.org/10.4049/jimmunol.1800365
Short Leucine-Rich Proteoglycans Modulate Complement Activity and Increase Killing of the Respiratory Pathogen Moraxella catarrhalis
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2721–2730, https://doi.org/10.4049/jimmunol.1800734
HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2731–2743, https://doi.org/10.4049/jimmunol.1701420
Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2744–2752, https://doi.org/10.4049/jimmunol.1800885
Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2753–2766, https://doi.org/10.4049/jimmunol.1800558
Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2767–2775, https://doi.org/10.4049/jimmunol.1701195
Innate Immunity and Inflammation
Diversification of Bw4 Specificity and Recognition of a Nonclassical MHC Class I Molecule Implicated in Maternal–Fetal Tolerance by Killer Cell Ig-like Receptors of the Rhesus Macaque
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2776–2786, https://doi.org/10.4049/jimmunol.1800494
IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2787–2798, https://doi.org/10.4049/jimmunol.1701463
Systems Immunology
The Histone Demethylase LSD1 Regulates B Cell Proliferation and Plasmablast Differentiation
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2799–2811, https://doi.org/10.4049/jimmunol.1800952
Transplantation
Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2812–2823, https://doi.org/10.4049/jimmunol.1800793
Tumor Immunology
EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2824–2831, https://doi.org/10.4049/jimmunol.1800839
Lysyl–Transfer RNA Synthetase Induces the Maturation of Dendritic Cells through MAPK and NF-κB Pathways, Strongly Contributing to Enhanced Th1 Cell Responses
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2832–2841, https://doi.org/10.4049/jimmunol.1800386
Inhaled IL-10 Suppresses Lung Tumorigenesis via Abrogation of Inflammatory Macrophage–Th17 Cell Axis
The Journal of Immunology, Volume 201, Issue 9, November 2018, Pages 2842–2850, https://doi.org/10.4049/jimmunol.1800141
