Volume 200, Issue 5
March 2018
Cover image
Cover image
On the cover: Immunofluorescence studies of an aspirate of a tophus from a patient with chronic gout. Low and high power fluorescent images demonstrate the presence of extracellular DNA associated with neutrophil granule proteins, consistent with neutrophil extracellular traps coating the needle-shaped monosodium urate crystals, the inciting agents of gout. Chatfield, S. M., K. Grebe, L. W. Whitehead, K. L. Rogers, T. Neb, J. M. Murphy, and I. P. Wicks. 2018. Monosodium urate crystals generate nuclease-resistant NETs via a distinct molecular pathway. J. Immunol. 200: 1802–1816.
ISSN 0022-1767
EISSN 1550-6606
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Volume 200, Issue 5, March 2018
In This Issue
In This Issue
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1531–1532, https://doi.org/10.4049/jimmunol.1890001
Letters to the Editor
Comment on “γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations”
The Journal of Immunology, Volume 200, Issue 5, March 2018, Page 1533, https://doi.org/10.4049/jimmunol.1701743
Response to Comment on “γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations”
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1533–1534, https://doi.org/10.4049/jimmunol.1701799
Pillars of Immunology
The Chemical Elucidation of Slow-Reacting Substance: Bronchospasm and Beyond
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1535–1537, https://doi.org/10.4049/jimmunol.1800037
Pillars Article: Leukotriene C: A Slow-Reacting Substance from Murine Mastocytoma Cells. Proc. Natl. Acad. Sci. USA. 1979. 76: 4275–4279
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1538–1542, https://doi.org/10.1093/jimmunol/200.5.1538
Brief Reviews
Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1543–1553, https://doi.org/10.4049/jimmunol.1701618
Cutting Edge
Cutting Edge: Nqo1 Regulates Irritant Contact Hypersensitivity against Croton Oil through Maintenance of Dendritic Epidermal T Cells
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1555–1559, https://doi.org/10.4049/jimmunol.1701389
Allergy and Other Hypersensitivities
Biased Generation and In Situ Activation of Lung Tissue–Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1561–1569, https://doi.org/10.4049/jimmunol.1700257
Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1570–1579, https://doi.org/10.4049/jimmunol.1700987
Autoimmunity
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1580–1592, https://doi.org/10.4049/jimmunol.1701280
Clinical and Human Immunology
cIAP1/2–TRAF2–SHP-1–Src–MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1593–1606, https://doi.org/10.4049/jimmunol.1700199
Copper Regulates the Canonical NLRP3 Inflammasome
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1607–1617, https://doi.org/10.4049/jimmunol.1700712
DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1618–1626, https://doi.org/10.4049/jimmunol.1601689
Immune Regulation
Activation and Regulation of Blood Vδ2 T Cells Are Amplified by TREM-1+ during Active Pulmonary Tuberculosis
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1627–1638, https://doi.org/10.4049/jimmunol.1700785
CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1639–1650, https://doi.org/10.4049/jimmunol.1701377
CD8α+CD11c+ Extracellular Vesicles in the Lungs Control Immune Homeostasis of the Respiratory Tract via TGF-β1 and IL-10
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1651–1660, https://doi.org/10.4049/jimmunol.1701447
Endoplasmic Reticulum–Bound Transcription Factor CREBH Stimulates RANKL-Induced Osteoclastogenesis
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1661–1670, https://doi.org/10.4049/jimmunol.1701036
CD22 Promotes B-1b Cell Responses to T Cell–Independent Type 2 Antigens
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1671–1681, https://doi.org/10.4049/jimmunol.1701578
Immune System Development
MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1682–1691, https://doi.org/10.4049/jimmunol.1701572
Immunogenetics
Human and Rhesus Macaque KIR Haplotypes Defined by Their Transcriptomes
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1692–1701, https://doi.org/10.4049/jimmunol.1701480
Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1702–1717, https://doi.org/10.4049/jimmunol.1700568
Immunotherapy and Vaccines
Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1718–1726, https://doi.org/10.4049/jimmunol.1700784
Infectious Disease and Host Response
Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1727–1736, https://doi.org/10.4049/jimmunol.1701473
CD8+ T Cells Lack Local Signals To Produce IFN-γ in the Skin during Leishmania Infection
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1737–1745, https://doi.org/10.4049/jimmunol.1701597
CD11b+ Dendritic Cell–Mediated Anti–Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1746–1760, https://doi.org/10.4049/jimmunol.1701109
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1761–1770, https://doi.org/10.4049/jimmunol.1701154
Innate Immunity and Inflammation
Antagonism of Integrin CD11b Affords Protection against Endotoxin Shock and Polymicrobial Sepsis via Attenuation of HMGB1 Nucleocytoplasmic Translocation and Extracellular Release
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1771–1780, https://doi.org/10.4049/jimmunol.1701285
GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1781–1789, https://doi.org/10.4049/jimmunol.1700604
Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1–Rich Endothelial Filopodia Formation
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1790–1801, https://doi.org/10.4049/jimmunol.1700702
Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1802–1816, https://doi.org/10.4049/jimmunol.1701382
PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1817–1828, https://doi.org/10.4049/jimmunol.1700639
The Complement C3a–C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1829–1838, https://doi.org/10.4049/jimmunol.1601386
Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1839–1852, https://doi.org/10.4049/jimmunol.1700544
Molecular and Structural Immunology
Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1853–1864, https://doi.org/10.4049/jimmunol.1701523
Locus-Specific Reversible DNA Methylation Regulates Transient IL-10 Expression in Th1 Cells
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1865–1875, https://doi.org/10.4049/jimmunol.1701162
Mucosal Immunology
Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1876–1888, https://doi.org/10.4049/jimmunol.1701532
Intestinal Epithelial Cell–Derived LKB1 Suppresses Colitogenic Microbiota
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1889–1900, https://doi.org/10.4049/jimmunol.1700547
Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1901–1916, https://doi.org/10.4049/jimmunol.1701512
Systems Immunology
Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1917–1928, https://doi.org/10.4049/jimmunol.1701099
Novel Immunological Methods
KEAP1 Editing Using CRISPR/Cas9 for Therapeutic NRF2 Activation in Primary Human T Lymphocytes
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1929–1936, https://doi.org/10.4049/jimmunol.1700812
Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB
The Journal of Immunology, Volume 200, Issue 5, March 2018, Pages 1937–1950, https://doi.org/10.4049/jimmunol.1700832
Corrections
Correction: The Effect of Inhibitory Signals on the Priming of Drug Hapten–Specific T Cells That Express Distinct Vβ Receptors
The Journal of Immunology, Volume 200, Issue 5, March 2018, Page 1951, https://doi.org/10.4049/jimmunol.1800019
Correction: Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients
The Journal of Immunology, Volume 200, Issue 5, March 2018, Page 1952, https://doi.org/10.4049/jimmunol.1800020
