Volume 194, Issue 12
June 2015
Cover image
Cover image
On the cover: IFN-γ drives macro-autophagy in mouse podocytes. Immortalized podocytes were stimulated with 1000 units/ml of IFN-γ for 12 h and stained with anti-LC3 (red) Ab. Actin fibers were identified by costaining with phalloidin–FITC (green) and nuclei were visualized by DAPI incorporation. Original magnification ×600. Chaudhary, K., R. Shinde, H. Liu, J. P. Gnana-Prakasam, R. Veeranan-Karmegam, L. Huang, B. Ravishankar, J. Bradley, N. Kvirkvelia, M. McManamin, et al. 2015. Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J. Immunol. 194: 5713–5724.
ISSN 0022-1767
EISSN 1550-6606
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Volume 194, Issue 12, June 2015
In Memoriam
J. Donald Capra, M.D. (1937–2015)
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5575–5576, https://doi.org/10.4049/jimmunol.1590010
In this Issue
In This Issue
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5577–5578, https://doi.org/10.4049/jimmunol.1590011
Brief Reviews
Nouvelle Cuisine: Platelets Served with Inflammation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5579–5587, https://doi.org/10.4049/jimmunol.1500259
Intestinal Fucose as a Mediator of Host–Microbe Symbiosis
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5588–5593, https://doi.org/10.4049/jimmunol.1500395
Cutting Edge
Cutting Edge: Role of Osteopontin and Integrin αv in T Cell–Mediated Anti-Inflammatory Responses in Endotoxemia
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5595–5598, https://doi.org/10.4049/jimmunol.1500623
Cutting Edge: T Follicular Helper Cell Differentiation Is Defective in the Absence of Bcl6 BTB Repressor Domain Function
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5599–5603, https://doi.org/10.4049/jimmunol.1500200
Cutting Edge: Bcl6-Interacting Corepressor Contributes to Germinal Center T Follicular Helper Cell Formation and B Cell Helper Function
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5604–5608, https://doi.org/10.4049/jimmunol.1500201
Cutting Edge: c-Kit Signaling Differentially Regulates Type 2 Innate Lymphoid Cell Accumulation and Susceptibility to Central Nervous System Demyelination in Male and Female SJL Mice
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5609–5613, https://doi.org/10.4049/jimmunol.1500068
Allergy and Other Hypersensitivities
Poly(inosinic-cytidylic) Acid–Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5615–5625, https://doi.org/10.4049/jimmunol.1402529
Nanotubes Connect CD4+ T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5626–5634, https://doi.org/10.4049/jimmunol.1401718
Haploinsufficiency for Stard7 Is Associated with Enhanced Allergic Responses in Lung and Skin
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5635–5643, https://doi.org/10.4049/jimmunol.1500231
CD155 (PVR/Necl5) Mediates a Costimulatory Signal in CD4+ T Cells and Regulates Allergic Inflammation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5644–5653, https://doi.org/10.4049/jimmunol.1401942
Antigen Recognition and Responses
The Notch Signaling Pathway Controls Short-Lived Effector CD8+ T Cell Differentiation but Is Dispensable for Memory Generation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5654–5662, https://doi.org/10.4049/jimmunol.1402837
Autoimmunity
Identification of the Inflammasome Nlrp1b as the Candidate Gene Conferring Diabetes Risk at the Idd4.1 Locus in the Nonobese Diabetic Mouse
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5663–5673, https://doi.org/10.4049/jimmunol.1400913
Immune Tolerance Induction with Multiepitope Peptide Derived from Citrullinated Autoantigens Attenuates Arthritis Manifestations in Adjuvant Arthritis Rats
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5674–5680, https://doi.org/10.4049/jimmunol.1402457
DCIR Maintains Bone Homeostasis by Regulating IFN-γ Production in T Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5681–5691, https://doi.org/10.4049/jimmunol.1500273
Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5692–5702, https://doi.org/10.4049/jimmunol.1402736
Analysis of Celiac Disease Autoreactive Gut Plasma Cells and Their Corresponding Memory Compartment in Peripheral Blood Using High-Throughput Sequencing
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5703–5712, https://doi.org/10.4049/jimmunol.1402611
Amino Acid Metabolism Inhibits Antibody-Driven Kidney Injury by Inducing Autophagy
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5713–5724, https://doi.org/10.4049/jimmunol.1500277
A CD153+CD4+ T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5725–5735, https://doi.org/10.4049/jimmunol.1500319
Clinical and Human Immunology
Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5736–5742, https://doi.org/10.4049/jimmunol.1401986
Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5743–5750, https://doi.org/10.4049/jimmunol.1401987
Characterization of a Human Platelet Antigen-1a–Specific Monoclonal Antibody Derived from a B Cell from a Woman Alloimmunized in Pregnancy
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5751–5760, https://doi.org/10.4049/jimmunol.1401599
TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5761–5774, https://doi.org/10.4049/jimmunol.1400472
Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5775–5780, https://doi.org/10.4049/jimmunol.1402945
Immune Regulation
Diverse Inflammatory Cytokines Induce Selectin Ligand Expression on Murine CD4 T Cells via p38α MAPK
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5781–5788, https://doi.org/10.4049/jimmunol.1500485
Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5789–5800, https://doi.org/10.4049/jimmunol.1402180
PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5801–5811, https://doi.org/10.4049/jimmunol.1401936
De Novo–Induced Self-Antigen–Specific Foxp3+ Regulatory T Cells Impair the Accumulation of Inflammatory Dendritic Cells in Draining Lymph Nodes
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5812–5824, https://doi.org/10.4049/jimmunol.1500111
Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5825–5837, https://doi.org/10.4049/jimmunol.1500082
Neonatal Exposure to Pneumococcal Phosphorylcholine Modulates the Development of House Dust Mite Allergy during Adult Life
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5838–5850, https://doi.org/10.4049/jimmunol.1500251
Involvement of the HCK and FGR src-Family Kinases in FCRL4-Mediated Immune Regulation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5851–5860, https://doi.org/10.4049/jimmunol.1401533
Immune System Development
Thymic Low Affinity/Avidity Interaction Selects Natural Th1 Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5861–5871, https://doi.org/10.4049/jimmunol.1401628
Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5872–5884, https://doi.org/10.4049/jimmunol.1402154
Immunogenetics
GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5885–5894, https://doi.org/10.4049/jimmunol.1500016
Immunotherapy and Vaccines
Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5895–5902, https://doi.org/10.4049/jimmunol.1500564
Diverse Antibody Genetic and Recognition Properties Revealed following HIV-1 Envelope Glycoprotein Immunization
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5903–5914, https://doi.org/10.4049/jimmunol.1500122
A Synthetic M Protein Peptide Synergizes with a CXC Chemokine Protease To Induce Vaccine-Mediated Protection against Virulent Streptococcal Pyoderma and Bacteremia
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5915–5925, https://doi.org/10.4049/jimmunol.1500157
The Frequency of Naive and Early-Activated Hapten-Specific B Cell Subsets Dictates the Efficacy of a Therapeutic Vaccine against Prescription Opioid Abuse
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5926–5936, https://doi.org/10.4049/jimmunol.1500385
Genetic Vaccines To Potentiate the Effective CD103+ Dendritic Cell–Mediated Cross-Priming of Antitumor Immunity
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5937–5947, https://doi.org/10.4049/jimmunol.1500089
Infectious Disease and Host Response
IL-33 Receptor ST2 Amplifies the Expansion of NK Cells and Enhances Host Defense during Mouse Cytomegalovirus Infection
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5948–5952, https://doi.org/10.4049/jimmunol.1500424
Candida albicans Stimulates IL-23 Release by Human Dendritic Cells and Downstream IL-17 Secretion by Vδ1 T Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5953–5960, https://doi.org/10.4049/jimmunol.1403066
Platelet-Activating Factor Receptor Contributes to Antileishmanial Function of Miltefosine
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5961–5967, https://doi.org/10.4049/jimmunol.1401890
Species-Specific Differences in the Expression and Regulation of α4β7 Integrin in Various Nonhuman Primates
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5968–5979, https://doi.org/10.4049/jimmunol.1402866
CXCL14 Displays Antimicrobial Activity against Respiratory Tract Bacteria and Contributes to Clearance of Streptococcus pneumoniae Pulmonary Infection
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5980–5989, https://doi.org/10.4049/jimmunol.1402634
Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5990–5998, https://doi.org/10.4049/jimmunol.1401489
Cryptococcal Heat Shock Protein 70 Homolog Ssa1 Contributes to Pulmonary Expansion of Cryptococcus neoformans during the Afferent Phase of the Immune Response by Promoting Macrophage M2 Polarization
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 5999–6010, https://doi.org/10.4049/jimmunol.1402719
Innate Immunity and Inflammation
Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6011–6023, https://doi.org/10.4049/jimmunol.1402797
Regulation of Neutrophilic Inflammation by Proteinase-Activated Receptor 1 during Bacterial Pulmonary Infection
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6024–6034, https://doi.org/10.4049/jimmunol.1500124
Batf2/Irf1 Induces Inflammatory Responses in Classically Activated Macrophages, Lipopolysaccharides, and Mycobacterial Infection
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6035–6044, https://doi.org/10.4049/jimmunol.1402521
IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15/IL-15Rα Production
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6045–6056, https://doi.org/10.4049/jimmunol.1402505
Glucocorticoid-Induced Leucine Zipper: A Critical Factor in Macrophage Endotoxin Tolerance
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6057–6067, https://doi.org/10.4049/jimmunol.1403207
The Distal Upstream Promoter in Ly49 Genes, Pro1, Is Active in Mature NK Cells and T Cells, Does Not Require TATA Boxes, and Displays Enhancer Activity
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6068–6081, https://doi.org/10.4049/jimmunol.1401450
Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6082–6089, https://doi.org/10.4049/jimmunol.1402469
CD81 Controls Immunity to Listeria Infection through Rac-Dependent Inhibition of Proinflammatory Mediator Release and Activation of Cytotoxic T Cells
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6090–6101, https://doi.org/10.4049/jimmunol.1402957
Molecular and Structural Immunology
Identification of a Nuclear Export Sequence in the MHC CIITA
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6102–6111, https://doi.org/10.4049/jimmunol.1402026
Determinants of Gliadin-Specific T Cell Selection in Celiac Disease
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6112–6122, https://doi.org/10.4049/jimmunol.1500161
Mucosal Immunology
Genetic Variation in SP-A2 Leads to Differential Binding to Mycoplasma pneumoniae Membranes and Regulation of Host Responses
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6123–6132, https://doi.org/10.4049/jimmunol.1500104
Transplantation
De Novo–Developed Antibodies to Donor MHC Antigens Lead to Dysregulation of MicroRNAs and Induction of MHC Class II
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6133–6143, https://doi.org/10.4049/jimmunol.1401848
Novel Immunological Methods
A Novel Lung Explant Model for the Ex Vivo Study of Efficacy and Mechanisms of Anti-Influenza Drugs
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6144–6154, https://doi.org/10.4049/jimmunol.1402283
Quantitative Profiling of Immune Repertoires for Minor Lymphocyte Counts Using Unique Molecular Identifiers
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6155–6163, https://doi.org/10.4049/jimmunol.1500215
A Population Response Analysis Approach To Assign Class II HLA-Epitope Restrictions
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6164–6176, https://doi.org/10.4049/jimmunol.1403074
Generation of TCR-Engineered T Cells and Their Use To Control the Performance of T Cell Assays
The Journal of Immunology, Volume 194, Issue 12, June 2015, Pages 6177–6189, https://doi.org/10.4049/jimmunol.1400958
Letters of Retraction
Retraction: Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling
The Journal of Immunology, Volume 194, Issue 12, June 2015, Page 6190, https://doi.org/10.4049/jimmunol.1500893
Corrections
Correction: Repression of Ccr9 Transcription in Mouse T Lymphocyte Progenitors by the Notch Signaling Pathway
The Journal of Immunology, Volume 194, Issue 12, June 2015, Page 6191, https://doi.org/10.4049/jimmunol.1500914
Correction: Viral MHC Class I-like Molecule Allows Evasion of NK Cell Effector Responses In Vivo
The Journal of Immunology, Volume 194, Issue 12, June 2015, Page 6192, https://doi.org/10.4049/jimmunol.1500965
Correction: Extracellular Vesicles Derived from Gram-Negative Bacteria, such as Escherichia coli, Induce Emphysema Mainly via IL-17A–Mediated Neutrophilic Inflammation
The Journal of Immunology, Volume 194, Issue 12, June 2015, Page 6193, https://doi.org/10.4049/jimmunol.1500973
