Volume 194, Issue 11
June 2015
Cover image
Cover image
On the cover: Trichrome stained image of fat tissue surrounding a human bronchial lymph node with lymphatic vessels in view. Several leukocytes nearby have endocytosed dark particulate matter. Studies in mice reveal phagocytic cells actively sampling lymph in fat, so these cells may have acquired particulate matter as it flowed through nearby lymphatics. Kuan, E. L., S. Ivanov, E. A. Bridenbaugh, G. Victora, W. Wang, E. W. Childs, A. M. Platt, C. V. Jakubzick, R. J. Mason, A. A. Gashev, M. Nussenzweig, M. A. Swartz, M. L. Dustin, D. C. Zawieja, and G. J. Randolph. 2015. Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node–homing adipose tissue dendritic cells. J. Immunol. 194: 5200–5210.
ISSN 0022-1767
EISSN 1550-6606
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Volume 194, Issue 11, June 2015
In this Issue
In This Issue
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5037–5038, https://doi.org/10.4049/jimmunol.1590009
Letters to the Editor
Comment on “Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells”
The Journal of Immunology, Volume 194, Issue 11, June 2015, Page 5039, https://doi.org/10.4049/jimmunol.1500381
Response to Comment on “Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells”
The Journal of Immunology, Volume 194, Issue 11, June 2015, Page 5039, https://doi.org/10.4049/jimmunol.1500789
Pillars of Immunology
Kill or Be Killed
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5041–5043, https://doi.org/10.4049/jimmunol.1500774
Pillars Article: Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis. Science. 1999. 286: 1957–1959
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5044–5046, https://doi.org/10.1093/jimmunol/194.11.5044
Brief Reviews
Prospects for Therapeutic Targeting of MicroRNAs in Human Immunological Diseases
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5047–5052, https://doi.org/10.4049/jimmunol.1403146
The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5053–5060, https://doi.org/10.4049/jimmunol.1500304
Allergy and Other Hypersensitivities
Platelet-Driven Leukotriene C4–Mediated Airway Inflammation in Mice Is Aspirin-Sensitive and Depends on T Prostanoid Receptors
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5061–5068, https://doi.org/10.4049/jimmunol.1402959
Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant–Induced Th2 Responses
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5069–5076, https://doi.org/10.4049/jimmunol.1402915
Autoimmunity
B Cell Antigen Presentation Is Sufficient To Drive Neuroinflammation in an Animal Model of Multiple Sclerosis
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5077–5084, https://doi.org/10.4049/jimmunol.1402236
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5085–5093, https://doi.org/10.4049/jimmunol.1403243
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5094–5102, https://doi.org/10.4049/jimmunol.1403015
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5103–5109, https://doi.org/10.4049/jimmunol.1500023
IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5110–5119, https://doi.org/10.4049/jimmunol.1401810
IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5120–5128, https://doi.org/10.4049/jimmunol.1403181
Anti–Factor H Autoantibodies in C3 Glomerulopathies and in Atypical Hemolytic Uremic Syndrome: One Target, Two Diseases
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5129–5138, https://doi.org/10.4049/jimmunol.1402770
Clinical and Human Immunology
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5139–5149, https://doi.org/10.4049/jimmunol.1401680
CD14++CD16+ Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5150–5160, https://doi.org/10.4049/jimmunol.1402409
Upregulation of the N-Formyl Peptide Receptors in Scleroderma Fibroblasts Fosters the Switch to Myofibroblasts
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5161–5173, https://doi.org/10.4049/jimmunol.1402819
Immune Regulation
High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5174–5186, https://doi.org/10.4049/jimmunol.1303316
T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5187–5199, https://doi.org/10.4049/jimmunol.1401938
Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5200–5210, https://doi.org/10.4049/jimmunol.1500221
Critical Role of Mast Cells and Peroxisome Proliferator–Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5211–5222, https://doi.org/10.4049/jimmunol.1401844
The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5223–5232, https://doi.org/10.4049/jimmunol.1402609
The Tolerogenic Function of Annexins on Apoptotic Cells Is Mediated by the Annexin Core Domain
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5233–5242, https://doi.org/10.4049/jimmunol.1401299
C-Reactive Protein Directly Suppresses Th1 Cell Differentiation and Alleviates Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5243–5252, https://doi.org/10.4049/jimmunol.1402909
Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5253–5260, https://doi.org/10.4049/jimmunol.1402996
Altered Connexin 43 Expression Underlies Age-Dependent Decrease of Regulatory T Cell Suppressor Function in Nonobese Diabetic Mice
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5261–5271, https://doi.org/10.4049/jimmunol.1400887
Immune System Development
Tumor-Associated and Disease-Associated Autoantibody Repertoires in Healthy Colostrum and Maternal and Newborn Cord Sera
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5272–5281, https://doi.org/10.4049/jimmunol.1402771
Immunotherapy and Vaccines
Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5282–5293, https://doi.org/10.4049/jimmunol.1402827
Mechanistic Assessment of PD-1H Coinhibitory Receptor–Induced T Cell Tolerance to Allogeneic Antigens
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5294–5304, https://doi.org/10.4049/jimmunol.1402648
B7H6-Specific Bispecific T Cell Engagers Lead to Tumor Elimination and Host Antitumor Immunity
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5305–5311, https://doi.org/10.4049/jimmunol.1402517
Infectious Disease and Host Response
Staphylococcus aureus Adenosine Inhibits sPLA2-IIA–Mediated Host Killing in the Airways
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5312–5319, https://doi.org/10.4049/jimmunol.1402665
Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell–Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5320–5328, https://doi.org/10.4049/jimmunol.1402918
CD8+ TCR Bias and Immunodominance in HIV-1 Infection
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5329–5345, https://doi.org/10.4049/jimmunol.1400854
Early Effector Cells Survive the Contraction Phase in Malaria Infection and Generate Both Central and Effector Memory T Cells
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5346–5354, https://doi.org/10.4049/jimmunol.1403216
MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5355–5365, https://doi.org/10.4049/jimmunol.1402557
Innate Immunity and Inflammation
C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5366–5374, https://doi.org/10.4049/jimmunol.1402429
HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5375–5387, https://doi.org/10.4049/jimmunol.1401909
Hypercapnia Inhibits Autophagy and Bacterial Killing in Human Macrophages by Increasing Expression of Bcl-2 and Bcl-xL
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5388–5396, https://doi.org/10.4049/jimmunol.1500150
The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5397–5406, https://doi.org/10.4049/jimmunol.1403009
Critical Role for IL-18 in Spontaneous Lung Inflammation Caused by Autophagy Deficiency
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5407–5416, https://doi.org/10.4049/jimmunol.1402277
The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5417–5425, https://doi.org/10.4049/jimmunol.1402703
Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5426–5436, https://doi.org/10.4049/jimmunol.1402006
miR-155 Deficiency Ameliorates Autoimmune Inflammation of Systemic Lupus Erythematosus by Targeting S1pr1 in Faslpr/lpr Mice
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5437–5445, https://doi.org/10.4049/jimmunol.1403028
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5446–5454, https://doi.org/10.4049/jimmunol.1403012
Differential Activation of Inflammatory Pathways in Testicular Macrophages Provides a Rationale for Their Subdued Inflammatory Capacity
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5455–5464, https://doi.org/10.4049/jimmunol.1401132
The Lung Is Protected from Spontaneous Inflammation by Autophagy in Myeloid Cells
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5465–5471, https://doi.org/10.4049/jimmunol.1403249
Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5472–5487, https://doi.org/10.4049/jimmunol.1401343
Molecular and Structural Immunology
Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5488–5496, https://doi.org/10.4049/jimmunol.1500087
Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5497–5508, https://doi.org/10.4049/jimmunol.1401218
CXCL12 Regulates through JAK1 and JAK2 Formation of Productive Immunological Synapses
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5509–5519, https://doi.org/10.4049/jimmunol.1402419
Mucosal Immunology
Mature Cystic Fibrosis Airway Neutrophils Suppress T Cell Function: Evidence for a Role of Arginase 1 but Not Programmed Death-Ligand 1
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5520–5528, https://doi.org/10.4049/jimmunol.1500312
Tumor Immunology
Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5529–5538, https://doi.org/10.4049/jimmunol.1403215
Proinflammatory Proteins S100A8/S100A9 Activate NK Cells via Interaction with RAGE
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5539–5548, https://doi.org/10.4049/jimmunol.1402301
Novel Immunological Methods
A Haptotaxis Assay for Leukocytes Based on Surface-Bound Chemokine Gradients
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5549–5558, https://doi.org/10.4049/jimmunol.1500148
Peripheral Blood–Derived Virus-Specific Memory Stem T Cells Mature to Functional Effector Memory Subsets with Self-Renewal Potency
The Journal of Immunology, Volume 194, Issue 11, June 2015, Pages 5559–5567, https://doi.org/10.4049/jimmunol.1402090
Corrections
Correction: Vector-Encoded Helicobacter Pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration
The Journal of Immunology, Volume 194, Issue 11, June 2015, Page 5568, https://doi.org/10.4049/jimmunol.1500649
Correction: The Acute Respiratory Distress Syndrome: From Mechanism to Translation
The Journal of Immunology, Volume 194, Issue 11, June 2015, Page 5569, https://doi.org/10.4049/jimmunol.1500741
Correction: In This Issue
The Journal of Immunology, Volume 194, Issue 11, June 2015, Page 5570, https://doi.org/10.4049/jimmunol.1500787
