Volume 190, Issue 6
March 2013
Cover image
Cover image
On the cover: JAWSII cells were infected with Chlamydia (MOI 10) for 72 h and examined by transmission electron microscopy (TEM). The infection is characterized by structural disintegration of chlamydial inclusions and release of bacteria into the cytosol. The TEM image was artificially colored in green (Chlamydia), blue (mitochondria), and orange (endolysosomal compartments). Fiegl, D., D. Kägebein, E. M. Liebler-Tenorio, T. Weisser, M. Sens, M. Gutjahr, and M. R. Knittler. 2013. Amphisomal route of MHC class I cross-presentation in bacteria-infected dendritic cells. J. Immunol. 190: 2791–2806.
ISSN 0022-1767
EISSN 1550-6606
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Volume 190, Issue 6, March 2013
In This Issue
In This Issue
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2475–2476, https://doi.org/10.4049/jimmunol.1390009
Letters to the Editor
Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 2477, https://doi.org/10.4049/jimmunol.1390002
Response to Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2477–2478, https://doi.org/10.4049/jimmunol.1390003
Brief Reviews
The Mechanism of Tissue-Restricted Antigen Gene Expression by AIRE
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2479–2482, https://doi.org/10.4049/jimmunol.1203210
Cutting Edge
Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2485–2489, https://doi.org/10.4049/jimmunol.1203208
Cutting Edge: Innate Memory CD8+ T Cells Are Distinct from Homeostatic Expanded CD8+ T Cells and Rapidly Respond to Primary Antigenic Stimuli
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2490–2494, https://doi.org/10.4049/jimmunol.1202988
Cutting Edge: Novel Vaccination Modality Provides Significant Protection against Mucosal Infection by Highly Pathogenic Simian Immunodeficiency Virus
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2495–2499, https://doi.org/10.4049/jimmunol.1202655
Antigen Recognition and Responses
Processing of Recombinant Listeria monocytogenes Proteins for MHC Class I Presentation Follows a Dedicated, High-Efficiency Pathway
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2501–2509, https://doi.org/10.4049/jimmunol.1201660
Autoimmunity
Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2510–2518, https://doi.org/10.4049/jimmunol.1202725
Tolerant Anti-Insulin B Cells Are Effective APCs
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2519–2526, https://doi.org/10.4049/jimmunol.1202104
The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2527–2535, https://doi.org/10.4049/jimmunol.1202928
Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2536–2543, https://doi.org/10.4049/jimmunol.1202689
Reduced CD18 Levels Drive Regulatory T Cell Conversion into Th17 Cells in the CD18hypo PL/J Mouse Model of Psoriasis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2544–2553, https://doi.org/10.4049/jimmunol.1202399
Clinical and Human Immunology
Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2554–2566, https://doi.org/10.4049/jimmunol.1202914
Proteolysis of Complement Factors iC3b and C5 by the Serine Protease Prostate-Specific Antigen in Prostatic Fluid and Seminal Plasma
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2567–2574, https://doi.org/10.4049/jimmunol.1200856
Immune Regulation
Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator–Activated Receptor α
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2575–2584, https://doi.org/10.4049/jimmunol.1201920
TLR7 Stimulation of APCs Results in Inhibition of IL-5 through Type I IFN and Notch Signaling Pathways in Human Peripheral Blood Mononuclear Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2585–2592, https://doi.org/10.4049/jimmunol.1200780
Sialoadhesin Ligand Expression Identifies a Subset of CD4+Foxp3− T Cells with a Distinct Activation and Glycosylation Profile
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2593–2602, https://doi.org/10.4049/jimmunol.1201172
Retinoic Acid Hypersensitivity Promotes Peripheral Tolerance in Recent Thymic Emigrants
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2603–2613, https://doi.org/10.4049/jimmunol.1200852
Regulatory T Cells Migrate to Airways via CCR4 and Attenuate the Severity of Airway Allergic Inflammation
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2614–2621, https://doi.org/10.4049/jimmunol.1202354
Ig-like Transcript 7, but Not Bone Marrow Stromal Cell Antigen 2 (Also Known as HM1.24, Tetherin, or CD317), Modulates Plasmacytoid Dendritic Cell Function in Primary Human Blood Leukocytes
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2622–2630, https://doi.org/10.4049/jimmunol.1202391
In Vivo Ablation of Plasmacytoid Dendritic Cells Inhibits Autoimmunity through Expansion of Myeloid-Derived Suppressor Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2631–2640, https://doi.org/10.4049/jimmunol.1201897
Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and Disease
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2641–2649, https://doi.org/10.4049/jimmunol.1202541
Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2650–2658, https://doi.org/10.4049/jimmunol.1202698
Immune System Development
The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of γδ NKT Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2659–2669, https://doi.org/10.4049/jimmunol.1202531
Ephrin-B–Dependent Thymic Epithelial Cell–Thymocyte Interactions Are Necessary for Correct T Cell Differentiation and Thymus Histology Organization: Relevance for Thymic Cortex Development
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2670–2681, https://doi.org/10.4049/jimmunol.1201931
Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2682–2691, https://doi.org/10.4049/jimmunol.1202534
Immunotherapy and Vaccines
Long-Term Antibody Memory Induced by Synthetic Peptide Vaccination Is Protective against Streptococcus pyogenes Infection and Is Independent of Memory T Cell Help
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2692–2701, https://doi.org/10.4049/jimmunol.1202333
Comparative Assessment of Clinically Utilized CD20-Directed Antibodies in Chronic Lymphocytic Leukemia Cells Reveals Divergent NK Cell, Monocyte, and Macrophage Properties
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2702–2711, https://doi.org/10.4049/jimmunol.1202588
Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2712–2719, https://doi.org/10.4049/jimmunol.1203082
Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2720–2735, https://doi.org/10.4049/jimmunol.1202861
Infectious Disease and Host Response
Anti–IFN-γ and Peptide-Tolerization Therapies Inhibit Acute Lung Injury Induced by Cross-Reactive Influenza A–Specific Memory T Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2736–2746, https://doi.org/10.4049/jimmunol.1201936
Evidence for Postinitiation Regulation of mRNA Biogenesis in Tuberculosis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2747–2755, https://doi.org/10.4049/jimmunol.1202185
B1a Cells Enhance Susceptibility to Infection with Virulent Francisella tularensis via Modulation of NK/NKT Cell Responses
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2756–2766, https://doi.org/10.4049/jimmunol.1202697
Priming of CD8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2767–2777, https://doi.org/10.4049/jimmunol.1200966
IL-10 Inhibits Mature Fibrotic Granuloma Formation during Mycobacterium tuberculosis Infection
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2778–2790, https://doi.org/10.4049/jimmunol.1202722
Amphisomal Route of MHC Class I Cross-Presentation in Bacteria-Infected Dendritic Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2791–2806, https://doi.org/10.4049/jimmunol.1202741
Microglia and a Functional Type I IFN Pathway Are Required To Counter HSV-1–Driven Brain Lateral Ventricle Enlargement and Encephalitis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2807–2817, https://doi.org/10.4049/jimmunol.1203265
The Drosophila Toll Pathway Controls but Does Not Clear Candida glabrata Infections
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2818–2827, https://doi.org/10.4049/jimmunol.1201861
CD4+ T Cell Persistence and Function after Infection Are Maintained by Low-Level Peptide:MHC Class II Presentation
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2828–2834, https://doi.org/10.4049/jimmunol.1202183
STING/MPYS Mediates Host Defense against Listeria monocytogenes Infection by Regulating Ly6Chi Monocyte Migration
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2835–2843, https://doi.org/10.4049/jimmunol.1201788
Innate Immunity and Inflammation
A Novel IRAK1–IKKε Signaling Axis Limits the Activation of TAK1–IKKβ Downstream of TLR3
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2844–2856, https://doi.org/10.4049/jimmunol.1202042
The α7β0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2857–2872, https://doi.org/10.4049/jimmunol.1200503
Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2873–2879, https://doi.org/10.4049/jimmunol.1203011
HLA Reduces Killer Cell Ig-like Receptor Expression Level and Frequency in a Humanized Mouse Model
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2880–2885, https://doi.org/10.4049/jimmunol.1200650
Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H–Dependent Resistance of Peripheral Platelets to Complement Attack
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2886–2895, https://doi.org/10.4049/jimmunol.1202536
Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2896–2903, https://doi.org/10.4049/jimmunol.1201351
IL-21 Enhances Phagocytosis in Mononuclear Phagocyte Cells: Identification of Spleen Tyrosine Kinase as a Novel Molecular Target of IL-21
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2904–2912, https://doi.org/10.4049/jimmunol.1201941
The NF-κB Inhibitory Proteins IκBα and IκBβ Mediate Disparate Responses to Inflammation in Fetal Pulmonary Endothelial Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2913–2923, https://doi.org/10.4049/jimmunol.1202670
Molecular and Structural Immunology
A Peptide Antagonist Disrupts NK Cell Inhibitory Synapse Formation
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2924–2930, https://doi.org/10.4049/jimmunol.1201032
A Polyglutamic Acid Motif Confers IL-27 Hydroxyapatite and Bone-Binding Properties
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2931–2937, https://doi.org/10.4049/jimmunol.1201460
The Requirement of Linker for Activation of T Cells in the Primary and Memory Responses of CD8 T Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2938–2947, https://doi.org/10.4049/jimmunol.1203163
Mucosal Immunology
Nucleotide-Binding Oligomerization Domain 2 Signaling Promotes Hyperresponsive Macrophages and Colitis in IL-10–Deficient Mice
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2948–2958, https://doi.org/10.4049/jimmunol.1201332
Rate of AIDS Progression Is Associated with Gastrointestinal Dysfunction in Simian Immunodeficiency Virus–Infected Pigtail Macaques
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2959–2965, https://doi.org/10.4049/jimmunol.1202319
Myeloma Is Characterized by Stage-Specific Alterations in DNA Methylation That Occur Early during Myelomagenesis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2966–2975, https://doi.org/10.4049/jimmunol.1202493
Transplantation
CD4+ T Cell–Depleted Lymphocyte Infusion Impairs Neither the Recovery of Recipient Thymus nor the Development of Transplanted Thymus
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2976–2983, https://doi.org/10.4049/jimmunol.1201605
Tumor Immunology
Control of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2984–2993, https://doi.org/10.4049/jimmunol.1201650
Eradication of Liver-Implanted Tumors by Semliki Forest Virus Expressing IL-12 Requires Efficient Long-Term Immune Responses
The Journal of Immunology, Volume 190, Issue 6, March 2013, Pages 2994–3004, https://doi.org/10.4049/jimmunol.1201791
Letters of Retraction
Retraction: Antisense Knockdown of Sphingosine Kinase 1 in Human Macrophages Inhibits C5a Receptor-Dependent Signal Transduction, Ca2+ Signals, Enzyme Release, Cytokine Production, and Chemotaxis
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 3005, https://doi.org/10.4049/jimmunol.1390006
Retraction: Phospholipase D1 Plays a Key Role in TNF-α Signaling
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 3006, https://doi.org/10.4049/jimmunol.1390007
Retraction: VAMP8 Is Essential in Anaphylatoxin-Induced Degranulation, TNF-α Secretion, Peritonitis, and Systemic Inflammation
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 3007, https://doi.org/10.4049/jimmunol.1390008
Corrections
Correction: PTP1B Deficiency Exacerbates Inflammation and Accelerates Leukocyte Trafficking In Vivo
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 3008, https://doi.org/10.4049/jimmunol.1390004
Correction: Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK Cells
The Journal of Immunology, Volume 190, Issue 6, March 2013, Page 3009, https://doi.org/10.4049/jimmunol.1390005
